Design of psyllium–PVA–acrylic acid based novel hydrogels for use in antibiotic drug delivery

Singh, Baljit; Sharma, Vikrant

doi:10.1016/j.ijpharm.2010.01.022

Cited by 55 publications

(17 citation statements)

References 25 publications

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“…The polysaccharides which have undergone modification include starch (Chen et al, 2007), cellulose (Hon, 1996), chitosan (Rinaudo, 2006), psyllium (Singh and Sharma, 2010) and guar-gum (Dodi et al, 2011). Carboxymethylation of arabinoxylan with sodium monochloroacetate resulted in replacement of -OH group with carboxymethyl group.…”

Section: Resultsmentioning

confidence: 99%

Modified and unmodified arabinoxylans from <i>Plantago ovata</i> husk: Novel excipients with antimicrobial potential

Erum

Bashir

Saghir³

2015

Bangladesh J Pharmacol

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Arabinoxylan is a polysaccharide of Plantago ovata, an indigenous plant of Pakistan and several European countries. In the present investigation arabinoxylan isolated from P. ovata husk was chemically modified i.e., carboxymethylated and was converted into its sodium salt. Physicochemical characterization of modified arabinoxylans was done. The antimicrobial assay of arabinoxylan and modified arabinoxylans was done by Kirby-Bauer disk diffusion method against Gram negative and Gram positive bacterial strains. Physicochemical properties of modified arabinoxylans were different from arabinoxylan yet were satisfactory for their use as pharmaceutical excipients. Arabinoxylan showed strong antimicrobial activity against Gram positive strains. However, it showed no antimicrobial activity against Gram negative strains. Carboxymethyl arabinoxylan showed maximum activity against S. epidermidis. It also showed activity against S. aureus and P. aeruginosa. Arabinoxylan Na showed concentration-dependent antimicrobial activity. This study provides the first report on the antibacterial properties of arabinoxylan and its modified forms. Article Info

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Section: Resultsmentioning

confidence: 99%

Modified and unmodified arabinoxylans from <i>Plantago ovata</i> husk: Novel excipients with antimicrobial potential

Erum

Bashir

Saghir³

2015

Bangladesh J Pharmacol

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“…As in the lower concentrations of alginate (1% w/v), the PSL effect is more dominant probably due to the fact that ALG concentration is insufficient for protection and addition of PSL increases the total polymer concentration and brings it to the appropriate point to remarkably increase the protection of the cells against acid conditions. Polymer blending is a simple yet attractive method to provide combined properties of polymers to a system and overcome their limitations [25]. This kind of compositions is widely used in encapsulation of probiotics.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Alginate and Psyllium Beads ContainingLactobacillus acidophilus

Lotfipour

Mirzaeei

Maghsoodi

2012

The Scientific World Journal

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This paper describes preparation and characterization of beads of alginate and psyllium containing probiotic bacteria of Lactobacillus acidophilus DMSZ20079. Twelve different formulations containing alginate (ALG) and alginate-psyllium (ALG-PSL) were prepared using extrusion technique. The prepared beads were characterized in terms of size, morphology and surface properties, encapsulation efficiency, viabilities in acid (pH 1.8, 2 hours) and bile (0.5% w/v, 2 hours) conditions, and release in simulated colon pH conditions. The results showed that spherical beads with narrow size distribution ranging from 1.59 ± 0.04 to 1.67 ± 0.09 mm for ALG and from 1.61 ± 0.06 to 1.80 ± 0.07 mm for ALG-PSL with encapsulation efficiency higher than 98% were achieved. Furthermore, addition of PSL into ALG enhanced the integrity of prepared beads in comparison with ALG formulations. The results indicated that incorporation of PSL into alginate beads improved viability of the bacteria in acidic conditions as well as bile conditions. Also, stimulating effect of PSL on the probiotic bacteria was observed through 20-hour incubation in simulated colonic pH solution. According to our in vitro studies, PSL can be a suitable polymer candidate for partial substitution with ALG for probiotic coating.

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“…This was because the hydrogels with lower concentrations of acrylic acid had more vacant spaces for the penetration of water molecules as compared to those having a higher degree of cross-linking due to a higher concentration of AA which resulted in a tougher structure, less swelling and consequently, less amount of drug release [9]. Other reasons which may result in less swelling were the increased viscosity of the release medium due to high AA concentration and increased ratio of homo-polymerization with respect to graft copolymerization [10].…”

Section: Discussionmentioning

confidence: 99%

Preparation and Characterization of Isosorbide Mononitrate Hydrogels Obtained by Free-Radical Polymerization for Site-Specific Delivery

Ranjha¹,

Madni²,

Bakar³

et al. 2015

Trop. J. Pharm Res

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Design of psyllium–PVA–acrylic acid based novel hydrogels for use in antibiotic drug delivery

Cited by 55 publications

References 25 publications

Modified and unmodified arabinoxylans from <i>Plantago ovata</i> husk: Novel excipients with antimicrobial potential

Modified and unmodified arabinoxylans from <i>Plantago ovata</i> husk: Novel excipients with antimicrobial potential

Preparation and Characterization of Alginate and Psyllium Beads ContainingLactobacillus acidophilus

Preparation and Characterization of Isosorbide Mononitrate Hydrogels Obtained by Free-Radical Polymerization for Site-Specific Delivery

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