Design of programmable multilayered nanoparticles with in situ manufacture of therapeutic genes for nanomedicine

Seale, Mary-Margaret; Haglund, Emily; Cooper, Carlton R.; Reece, Lisa M.; Leary, James F.

doi:10.1117/12.701619

Cited by 4 publications

(3 citation statements)

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“…As that function is realized, the layer is either literally or figuratively stripped off to reveal the next layer. This layer-by-layer disassembly allows precise control of the multistep process in a form of chemical programming, 11 as shown in Figure 5.…”

Section: A General Model Of a Nanomedical Device For Drug Or Gene Delmentioning

confidence: 99%

Nanotechnology: what is it and why is small so big?

Leary

2010

Canadian Journal of Ophthalmology

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Section: A General Model Of a Nanomedical Device For Drug Or Gene Delmentioning

confidence: 99%

Nanotechnology: what is it and why is small so big?

Leary

2010

Canadian Journal of Ophthalmology

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“…Some key functions that a nanobiosystem must be able to perform include: targeting, monitoring, external manipulation, error‐checking, delivery, and degradation/stealth function. A general schematic of such multifunctional nanobiosystems as described in several publications 39–43 is shown in Figure 1. For example, doxorubicin‐loaded thermo‐sensitive micelles combined with ultrasound sonication were able to target and deliver drug to cancer cell xenografts in nude mice, and results indicated significant reduction in tumor volumes 44.…”

Section: Types Of Nanobiosystemsmentioning

confidence: 99%

“…A relatively recent nanometrology tool known as XPS is used to bombard the surface layers of nanobiosystems to release inner core electrons that have a distinct pattern of energies. XPS analysis can determine whether specific molecules are attached to the nanoparticle as shown in Figure 3 42…”

Section: How Do We See and Measure Nanobiosystems?mentioning

confidence: 99%

Nanobiosystems

Seale-Goldsmith

Leary

2009

WIREs Nanomed Nanobiotechnol

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'Nanobiosystems' is a relatively new term describing objects in the size range below 150 nm and having structures or functions that link to biological functions. Key features are that these nanosized objects typically self-assemble, are not capable of self-replication, and have functions that take advantage of its size. Nanobiosystems can be made entirely of biological or organic molecules that are organized into nanoparticles (e.g., liposomes, dendrimers) or be totally inorganic (with the exception of surface coatings used for biocompatibility) nanoparticles (e.g., gold, iron oxide, quantum dot nanocrystals). More complex nanobiosystems are inorganic/biologic hybrid composites that may include complex multilayered structures with targeting molecules (e.g., peptides, antibodies, aptamers), cell entry-promoting molecules (e.g., HIV-tat peptide sequence), drugs (small molecules), genes (therapeutic genes, reporter genes), and core nanomaterials (e.g., gold, quantum dot, iron oxide) that give the nanobiosystems sometimes unique detection capabilities by a variety of optical and non-optical modalities (fluorescence, surface plasmon resonance, magnetic resonance imaging).

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Magnetic Nanoparticles for Advanced Drug Delivery

Leary

2023

Studies in Mechanobiology, Tissue Engineering and Biomaterials

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Design of programmable multilayered nanoparticles with in situ manufacture of therapeutic genes for nanomedicine

Cited by 4 publications

References 0 publications

Nanotechnology: what is it and why is small so big?

Nanotechnology: what is it and why is small so big?

Nanobiosystems

Magnetic Nanoparticles for Advanced Drug Delivery

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