Design of Polymeric Systems for Targeted Administration of Peptide and Protein Drugs

Chiellini, Elisabetta E.; Chiellini, Federica; Solaro, Roberto

doi:10.1201/9781420010251.ch4

Cited by 3 publications

(4 citation statements)

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“…Convenient procedures for the preparation of both malolactone monomers and the corresponding polymers have been developed over the last 20 years starting from commercially available natural products. [21][22][23] Following our continued interest in the production of bioerodible and biodegradable functional polymers for biomedical applications, [24][25][26][27][28][29][30][31][32] we synthesized and characterized a series of polyesters and copolyesters from new malolactonate monomers. Functionalization of the lateral chain of the malic residues was performed through esterification with readily available alcohols.…”

Section: Introductionmentioning

confidence: 99%

“…Following our continued interest in the production of bioerodible and biodegradable functional polymers for biomedical applications, − we synthesized and characterized a series of polyesters and copolyesters from new malolactonate monomers. Functionalization of the lateral chain of the malic residues was performed through esterification with readily available alcohols.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of New Malolactonate Polymers and Copolymers for Biomedical Applications

et al. 2002

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A new class of malolactonate polymers and copolymers were synthesized, starting from the corresponding lactones, and then characterized. Different lateral groups were selected for these polyesters to achieve a wide range of materials characteristics and possible biological recognition. The monomers were prepared according to two established procedures, which gave rather good overall yields. The polymers were obtained by the anionic ring-opening polymerization of the corresponding four-member ring monomers in the presence of a quaternary ammonium salt as the initiator. Final macromolecular and thermal characteristics were in agreement with the designed monomer structures. Molecular weights in the range 4-20 kDa were obtained, as a result of chain transfer reactions. The prepared polyesters displayed stability up to 200°C, and, when tested in preliminary cell culture experiments, provided indications for future applications in the biomedical field.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of New Malolactonate Polymers and Copolymers for Biomedical Applications

et al. 2002

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“…9 10 These receptors can recognize the galactose units on the oligosaccharide chains of glycoproteins or on chemically galactosylated drug carriers. 11 In the framework of a long-standing activity in the development of biocompatible polymers for biomedical and tissue engineering applications, [12][13][14][15][16][17][18][19][20][21] in a previous paper 18 we reported the formulations of nanoparticles loaded with -interferon ( -IFN), a proteic drug widely used in the treatment of hepatitis C. These carriers were prepared in order to achieve targeted and controlled delivery of -IFN to hepatocytes, the liver parenchymal cells that are affected by hepatitis C viral infection. To the best of our knowledge, no previous report on the targeted delivery of drugs to liver hepatocytes by biodegradable nanoparticles is present in the literature.…”

Section: Introductionmentioning

confidence: 99%

Bioerodible Polymeric Nanoparticles for Targeted Delivery of Proteic Drugs

Chiellini¹,

Chiellini²,

Solaro³

2006

j nanosci nanotechnol

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Significant efforts are being devoted to develop nanotechnology for drug delivery, mainly because of the distinct advantages offered by nanometer-size polymeric systems. Moreover, targeted drug delivery can be obtained by polymer conjugation to biospecific ligands. The present investigation was aimed mainly at determining the targeting ability of hybrid nanoparticles based on synthetic polymer/protein hybrid matrices. These nanoparticles were designed for liver targeted release of proteic drugs with antiviral activity, such as alpha-interferon. Human serum albumin and the monoesters of alternating copolymers of maleic anhydride/alkyl vinyl ethers of oligo(ethylene glycol) were selected as proteic and synthetic components, respectively. Digalactosyl diacyl glycerol, a natural glycolipid selectively recognized by the asialofetuin receptor present on liver hepatocytes was used as active targeting agent. Nanoparticles of 100-300 nm average size were obtained by controlled coprecipitation method. Investigation of nanoparticle surface properties by spectroscopic analysis and by biological tests indicated that the synthesized nanoparticles do expose on their surface targeting moieties that selectively interact with liver hepatocytes receptors.

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“…Following our continuing interest in the production of bioerodible and biodegradable functional polymers for biomedical application23–32 we prepared homopolymers and copolymers of new malolactonate monomers bearing side ester groups specifically designed for biological recognition, with the goal of obtaining highly effective polymeric scaffolds 33. The present paper reports a preliminary investigation of the monomer molecular geometry and its influence on the polymerization process.…”

Section: Introductionmentioning

confidence: 99%

Influence of structural parameters on the ring-opening polymerization of new alkyl malolactonate monomers and on the biocompatibility of polymers therefrom

Bizzarri

Chiellini

Ober

et al. 2002

Macromol. Chem. Phys.

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The geometry of several alkyl malolactonate monomers was investigated by NMR and semiempirical computational methods. The results obtained by both techniques indicated that the geometry of the malolactone ring is almost independent of the nature of the side ester group. 13C NMR analysis of the polymer backbone stereochemistry ruled out the occurrence of stereoelective processes in the polymerization of racemic monomers. The observed influence of the bulkiness of the alkyl group on the polymerization rate was therefore attributed to steric interactions between this group and the polymer growing‐end. Preliminary in‐vitro investigation of cell adhesion and proliferation on the surface of homopolymers and copolymers of the investigated alkyl malolactonates suggested a possible correlation between polymer hydrophobicity and biocompatibility.

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Design of Polymeric Systems for Targeted Administration of Peptide and Protein Drugs

Cited by 3 publications

References 10 publications

Synthesis and Characterization of New Malolactonate Polymers and Copolymers for Biomedical Applications

Synthesis and Characterization of New Malolactonate Polymers and Copolymers for Biomedical Applications

Bioerodible Polymeric Nanoparticles for Targeted Delivery of Proteic Drugs

Influence of structural parameters on the ring-opening polymerization of new alkyl malolactonate monomers and on the biocompatibility of polymers therefrom

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