Design of polymeric inhibitors for the control of crystal polymorphism. Induced enantiomeric resolution at racemic histidine by crystallization at 25.degree.C

Weissbuch, Isabelle; Zbaida, David; Addadi, Lia; Leiserowitz, Leslie; Lahav, Meir

doi:10.1021/ja00240a052

Cited by 81 publications

(64 citation statements)

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“…The presence of impurities is known to affect crystal nucleation of the α-amino acids, as manifested by the precipitation of different polymorphs (Weissbuch et al, 1987(Weissbuch et al, , 1994. More direct insight into the role played by impurities on the early stages of crystal nucleation was provided by grazing incidence X-ray diffraction, atomic force microscopy and transmission electron microscopy studies (PopovitzBiro et al, 1994).…”

Section: Role Of Impurities In Crystallization Processesmentioning

confidence: 99%

Parity Violating Energetic Difference and Enantiomorphous Crystalsp-Caveats; Reinvestigation of Tyrosine Crystallization

Lahav

Weissbuch

Shavit

et al. 2006

Orig Life Evol Biosph

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The present article challenges reports claiming to have demonstrated the Parity Violating Energetic Difference (PVED) between enantiomorphous D- and L-crystals. Apart from PVED, the presence of minute quantities and differing profiles of impurities incorporated during their different history of preparation will affect the physical properties of D- and L-crystals. These impurities are anticipated to play a much greater role in affecting crystallization behavior than PVED. The effect of impurities on the growth and dissolution of enantiomorphous crystals is illustrated with some representative examples. Shinitzky et al. (2002) reported recently dramatic differences in the growth and dissolution properties of the D- and L-crystals of tyrosine. We have repeated these experiments using commercial samples from different sources and employing a validated enantioselective gas chromatographic technique. We attribute Shinitzky's findings either to the use of inappropriate analytical techniques for the determination of enantiomeric composition and/or to the presence of unidentified contaminants in the commercial tyrosine samples. Related caveats hold also for the recently published claims by Shinitzky (2006) and Scolnik et al. (2006) to have observed experimentally PVED between enantiomeric helices of poly-glutamic acid composed of 24 repeating units.

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Section: Role Of Impurities In Crystallization Processesmentioning

confidence: 99%

Parity Violating Energetic Difference and Enantiomorphous Crystalsp-Caveats; Reinvestigation of Tyrosine Crystallization

Lahav

Weissbuch

Shavit

et al. 2006

Orig Life Evol Biosph

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“…Surfactant assemblies have also been employed in controlling the size of mesopores in MCM-41 type silica, a material that has a number of potential applications in catalysis, as a host for quantum size effect electronic materials and in wave guiding [54,99,100]. Alternative biomimetic approaches to the control of mineral nucleation and growth have been to use soluble macromolecules as growth inhibitors [86,101] and the absorption of macromolecules onto rigid substrates to act as nucleators [102].…”

Section: Biomineralisation and The Role Of The Organic Matrix In Strumentioning

confidence: 99%

Biosilicification: the role of the organic matrix in structure control

2000

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Silicon (although never in the elemental form) is present in all living organisms and is required for the production of structural materials in single-celled organisms through to higher plants and animals. Hydrated amorphous silica is a mineral of infinite functionality and yet it is formed into structures with microscopic and macroscopic form. Research into the mechanisms controlling the process have highlighted proteins and proteoglycans as possible control molecules. Such molecules are suggested to play a critical role in the catalysis of silica polycondensation reactions and in structure direction. This article reviews information on silica form and function, silica condensation chemistry, the role of macromolecules in structure control and in vitro studies of silica formation using biomolecules extracted from biological silicas. An understanding of the mechanisms by which biological organisms regulate mineral formation will assist in our understanding of the essentiality of silicon to life processes and in the generation of new materials with specific form and function for industrial application in the 21st century.

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“…The inhibition of crystal growth along certain directions in solution was demonstrated by tailor-made additives that adsorbed specifically by structural matching to planes of a mature crystal. [8] Biomineralization in general has been linked to acidic proteins in b-sheet conformation. The major acidic protein of tooth enamel, enamelin, has been shown to fold into b-sheet structure during enamel formation.…”

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confidence: 99%

Matrices of Acidic β‐Sheet Peptides as Templates for Calcium Phosphate Mineralization

et al. 2008

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De novo designed amphiphilic and acidic β‐sheet peptides in the form of monolayers and fibril assemblies are used as templates for monitoring calcium phosphate nucleation. The regular arrangement of negatively charged aspartic acid residues in a solution supersaturated with respect to apatite induces the nucleation of amorphous calcium phosphate, which over time transforms into apatite (see figure). This study demonstrates the bottom‐to‐top design and synthesis of new mineralized‐peptide composite biomaterials.

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Design of polymeric inhibitors for the control of crystal polymorphism. Induced enantiomeric resolution at racemic histidine by crystallization at 25.degree.C

Cited by 81 publications

References 0 publications

Parity Violating Energetic Difference and Enantiomorphous Crystalsp-Caveats; Reinvestigation of Tyrosine Crystallization

Parity Violating Energetic Difference and Enantiomorphous Crystalsp-Caveats; Reinvestigation of Tyrosine Crystallization

Biosilicification: the role of the organic matrix in structure control

Matrices of Acidic β‐Sheet Peptides as Templates for Calcium Phosphate Mineralization

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