Design of polyazamacrocyclic Gd³⁺ theranostic agents combining magnetic resonance imaging and two-photon photodynamic therapy

Abstract

New “all-in-one” theranostic systems, combining a magnetic resonance imaging (MRI) contrast agent with a biphotonic photodynamic therapy (2P-PDT) photosensitiser generating cytotoxic singlet oxygen, were envisaged and synthesised. They are based...

Tuning Excited-State Properties of [2.2]Paracyclophane-Based Antennas to Ensure Efficient Sensitization of Lanthanide Ions or Singlet Oxygen Generation

“…The generation of singlet oxygen was also observed with a quantum yield of 0.45, which is slightly lower than the A 2 antenna (Figure S11). This value is in the range of that observed in the literature. − ,− …”

“…A large variety of chromophores have been tested as antennae, such as polyaromatic dyes (anthracene or pyrene), , xanthene and coumarin derivatives, , π-conjugated chromophores (Michler ketone, tetrathiafulavalene, or dipolar dyes , ), coordination or organometallic complexes, , porphyrins, dithienylethene, murexide, , BODIPY dyes, , etc. On the other hand, besides porphyrinic ligands, − the research of original antenna ligand suitable for the sensitization of singlet oxygen is nowadays a very active area for application in photodynamic therapy (PDT) or in the design of multimodal theranostic probes combining therapy and diagnostics. − In this domain, the potentiality of the [2.2]-paracyclophane (pCp) moiety is completely unexplored.…”

Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

“…This ultrahigh luminescence stability of octahedral Mo 6 nanoclusters originated from their strong and homogeneous interactions with the host matrix, which can greatly inhibit any unwanted phase segregation or leaching of integrated Mo 6 nanoclusters. Known for about 90 years, luminescence induced via two-photon absorption is still an appealing and critical research direction that is of particular relevance when dealing with high-resolution imaging and photocytotoxic therapy. − Octahedral Mo 6 clusters, with evidence of two-photon absorption-induced highly stable NIR-I phosphorescence, will afford new opportunities in broadening the library of in vivo bioimaging probes.…”

Recent progress in the chemistry of 12-membered pyridine-containing tetraazamacrocycles: from synthesis to catalysis

“…Besides, the Gd( iii ) complex Gd III L25 bearing a single picolinate antenna at position 3 was also described. 30 The synthesis required the use of disubstituted pyclen ligand 39 and a more elaborate picolinate 35 . Following the same synthetic approach, complex Gd III L25 was obtained in a remarkable high overall yield.…”