Abstract:Background:
Cancer has been regarded as the leading cause of death worldwide. Identifying new anti-neoplastics with high potency and low toxicity is urgent.
Objective:
Podophyllotoxin-based hybrid compounds were synthesized by esterification and characterized using NMR and HR-MS. In vitro cytotoxicity and molecular mechanism studies were performed.
Methods:
Podophyllotoxin was hybridized with three selected known natural compounds via esterification to develop candidates with increased biological activity … Show more
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