Design of Parenteral Synthetic Dipeptides for Clinical Nutrition: In vitro and in vivo Utilization

Fürst, Peter; Pogan, Karin; Hummel, Monika; Herzog, Birgit; Stehle, Peter

doi:10.1159/000177973

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Utilization Of Dipeptides: In Vitro Studies1

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Cited by 13 publications

(1 citation statement)

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“…Hydrolase activities against these conjugates are considerably higher in rat mucosa and kidney homogenates than in plasma. 61,62 Additionally, in subcellular fractions of rat mucosa the hydrolase capacities of the brush border membrane vesicles and cytosol were at least 300-fold and 30-fold higher, respectively, than in plasma. The existence of considerable membrane-bound and intracellular hydrolase activity suggests that amino acid-taurine conjugates might be used as efficient sources of free taurine in clinical nutrition.…”

Section: Utilization Of Dipeptides: In Vitro Studiesmentioning

confidence: 97%

A Thirty‐Year Odyssey in Nitrogen Metabolism: From Ammonium to Dipeptides

Fürst

2000

J Parenter Enteral Nutr

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Section: Utilization Of Dipeptides: In Vitro Studiesmentioning

confidence: 97%

A Thirty‐Year Odyssey in Nitrogen Metabolism: From Ammonium to Dipeptides

Fürst

2000

J Parenter Enteral Nutr

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New Nitrogen-Containing Substrates in Artificial Nutrition

Fürst

Kuhn

Stehle

2002

From Nutrition Support to Pharmacologic Nutrition in the ICU

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Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine

et al. 2005

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The objective of this study was to determine the dose as well as duration of exposure-dependent effects of L-alanyl-L-glutamine, arginine or taurine on polymorphonuclear neutrophil (PMN) free alpha-keto acid profiles and, in a parallel study, on PMN immune functions. Exogenous L-alanyl-L-glutamine significantly increased PMN alpha-ketoglutarate, pyruvate PMN superoxide anion (O2-) generation, hydrogen peroxide (H2O2) formation and released myeloperoxidase (MPO) activity. Arginine also led to significant increases in alpha-ketoglutarate, pyruvate, MPO release and H2O2 generation. Formation of O2- on the other hand was decreased by arginine. Incubation with taurine resulted in lower intracellular pyruvate and alpha-ketobutyrate levels, decreased O2- and H2O2 formation and a concomitant significantly increased MPO activity. We therefore believe that considerable changes in PMN free-alpha-keto-acid profiles, induced for example by L-alanyl-L-glutamine, arginine or taurine, may be one of the determinants in cell nutrition that considerably modulates the immunological competence of PMN.

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Design of Parenteral Synthetic Dipeptides for Clinical Nutrition: In vitro and in vivo Utilization

Cited by 13 publications

References 23 publications

A Thirty‐Year Odyssey in Nitrogen Metabolism: From Ammonium to Dipeptides

A Thirty‐Year Odyssey in Nitrogen Metabolism: From Ammonium to Dipeptides

New Nitrogen-Containing Substrates in Artificial Nutrition

Alterations in neutrophil (PMN) free intracellular alpha-keto acid profiles and immune functions induced by L-alanyl-L-glutamine, arginine or taurine

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