Design of optimized diffusion-controlled transdermal drug delivery systems

Nauman, E. Bruce; Patel, Kandarp; Karande, Pankaj

doi:10.3109/03639045.2010.495751

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…It was determined that spatial variation of an API can significantly influence its release and provide improved performance compared with a monolithic DIA when distributed appropriately (46). Nauman et al further expanded this idea by creating a model that can predict optimal patch design configuration for a single drug that is distributed in a bilayer based on minimizing the burst effect and maximizing drug depletion to increase patch efficiency (47). Both authors concluded that increased drug loading within the second layer increases controlled release and decreases burst effect.…”

Section: Altered Patch Design With Maintained Composition Altered Drug Permeation Of Each Apimentioning

confidence: 99%

Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients

et al. 2020

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A transdermal drug delivery system (TDDS) is generally designed to deliver an active pharmaceutical ingredient (API) through the skin for systemic action. Permeation of an API through the skin is controlled by adjusting drug concentration, formulation composition, and patch design. A bilayer, drug-in-adhesive TDDS design may allow improved modulation of the drug release profile by facilitating varying layer thicknesses and drug spatial distribution across each layer. We hypothesized that the co-release of two fixed-dose APIs from a bilayer TDDS could be controlled by modifying spatial distribution and layer thickness while maintaining the same overall formulation composition. Franz cell diffusion studies demonstrated that three different bilayer patch designs, with different spatial distribution of drug and layer thicknesses, could modulate drug permeation and be compared with a reference single-layer monolith patch design. Compared with the monolith, decreased opioid antagonist permeation while maintaining fentanyl permeation could be achieved using a bilayer design. In addition, modulation of the drug spatial distribution and individual layer thicknesses, control of each drug's permeation could be independently achieved. Bilayer patch performance did not change over an 8-week period in accelerated stability storage conditions. In conclusion, modifying the patch design of a bilayer TDDS achieves an individualized permeation of each API while maintaining constant patch composition.

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Section: Altered Patch Design With Maintained Composition Altered Drug Permeation Of Each Apimentioning

confidence: 99%

Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients

et al. 2020

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“…Traditionally, the skin, the SC and the diffusion phenomena have been studied associated with pure mathematical models, especially based on the Fick Equation [24][25][26][27][28][29][30][31][32]. A systematic analysis of these models implies a division based upon the particular approach and use of the Fick Law.…”

Section: Dermic Diffusion and Mathematical Models: A Reviewmentioning

confidence: 99%

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Couto

Fernandes

Cordeiro

et al. 2014

Journal of Controlled Release

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A B S T R A C TTransdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.

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Optimization Methodologies for the Production of Pharmaceutical Products

Escotet‐Espinoza

Rogers

Ierapetritou

2016

Methods in Pharmacology and Toxicology

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Finding the most beneficial conditions during the development of a given product or process is among one of the top goals for both scientist and engineers across all industries. In the pharmaceutical industry, as global competition increases and there is a higher demand for accessible quality products, it is important to focus on the improvement of product development and manufacturing. Optimization methodologies can greatly aid the production of pharmaceutical products by providing a systematic framework to process improvement. In this review, general concepts regarding the implementation of optimization methods are introduced along with examples of their application in pharmaceutical manufacturing process design and formulation development. An overview of optimization methodologies used for the improvement of batch and continuous pharmaceutical manufacturing is presented. Challenges in the application of optimization methods in pharmaceutical manufacturing are discussed along with a future outlook of the field and its place in pharmaceutical process and product design. Overall the review points to optimization as a critical component in the design of improved and effective pharmaceutical products, in alignment with the common goals of both regulatory agencies and industry.

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Design of optimized diffusion-controlled transdermal drug delivery systems

Abstract: The proposed design is almost universally applicable and satisfies therapeutically relevant specifications while maximizing drug utilization.

Cited by 7 publications

References 30 publications

Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients

Complex Drug Delivery Systems: Controlling Transdermal Permeation Rates with Multiple Active Pharmaceutical Ingredients

Dermic diffusion and stratum corneum: A state of the art review of mathematical models

Optimization Methodologies for the Production of Pharmaceutical Products

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