Design of novel iron compounds as potential therapeutic agents against tuberculosis

Ruthenium(II) phosphine/diimine/picolinate complexes: Inorganic compounds as agents against tuberculosis

“…One of them is based on the synthesis of analogues of existing drugs, with the aim of shortening and improving TB treatment. The other involves a search for novel structures with which mycobacteria have never been challenged before [7]. Adopting this second approach, our research is focused on the synthesis and characterization of new compounds, specifically new metal complexes.…”

“…Owing to their wide spectrum of coordination numbers and geometries, as well as kinetic properties, metal compounds offer mechanisms of drug action that cannot be realized by organic agents [7,8]. Ruthenium compounds have already exhibited potential anti-tumour activity since the 1970s and 1980s, and, more recently, the Ru(III) complexes NAMI-A and KP 1019 (FFC14a) have entered clinical trials.…”

Synthesis and Antimicrobial Activity of Benzo[H][1,6]Naphthyridine Derivatives

“…Quinoline derivatives have demonstrated anti-leishmanial activity, antibacterial, antifungal, anti HIV and antitumor activity [16][17][18][19]. Recently, 4-amino-7-chloro-quinoline derivatives have demonstrated mycobacterium tuberculosis activity [20][21][22][23][24][25][26][27][28][29]. Benzo[h] [1,6]naphthyridine derivatives also showed antimalarial activity 5 [30].…”

Synthesis and Characterization of Heteroleptic Copper and Zinc Complexes with Saccharinate and Aminoacids. Evaluation of SOD-like Activity of the Copper Complexes

“…As a part of our work [5,[28][29][30][31] in the development of metal complexes with pharmacological activities or pharmacotechnical interest, in this article, the synthesis and analytical characterization of new mixed Cu(II) and Zn(II) complexes with saccharin and aminoacids are reported. The essential α-amino acids glycine (gly), serine (ser), and glutamine (gln) were selected taking into account the different chemical functions of R residue (COOHCH(NH 2 )R).…”