Design of nickel chelates of tetradentate N-heterocyclic carbenes with subdued cytotoxicity

Nickel N-heterocyclic carbene complexes and their utility in homogeneous catalysis

“…In particular, the (533−534), [163] (535), [164] (536), [165] (543−544), [166] (545−546), [167] (548 [168]−557), [169] (558), [51] (559), [71] (560), [161] (561), [170] (562−563), [141] (565), [171] (566−567), [172] (568), [173] (569), [126d] (570−573), [174] (574), [175] (575−576), [176] (577), [177] (578), [178] (579), [106] (580−581), [179] (582−583), [151] (584−585), [180] (586−588), [181] (595−596), [182] (597−599), [183] (600−603), [184] (604), [185] (605−608), [186] (609), [185] (610−613), [187] (614−618), [188] (619−621), [189] (622−623), [185] (624−630), [190] (631), [191] (633−635), [192] (636), [193] (637), [194] (647) [195] and (648) [196] complexes were obtained by this pathway from the treatment of the free or the in situ generated NHC The third route is the oxidation method (Scheme 15) using which the (589−590), [197] (638) …”

Bifunctional nickel precatalysts of amido-functionalized N-heterocyclic carbenes for base-free Michael reaction under ambient conditions

“…With one of the ongoing theme of our research being in exploring the biomedical [26,27] and catalytic [28e41] potentials of N-heterocyclic carbene [42e47] complexes of transition metals, we became interested in constructing a variety of CeX (X ¼ C, heteroatom) bonds catalytically, including the base-free Michael reactions using bifunctional catalysts [48,49]. We rationalized that q Dedicated to Professor Christian Bruneau on his 60th birthday.…”

Platinum(II) complexes with amide-functionalized NHC ligands

“…2, IV) [38e40] or the dianionic C * NNC * ligands (Fig. 2, V) [37,41] there have been (to the best of our knowledge) no reports of di(imidazol-2-ylidene) ligands with amide-functionalized side chains.…”