Design of nanogold electrochemical immunosensor for detection of four phenolic estrogens

Pan, Guangpin; Zhao, Guozheng; Wei, Meng; Wang, Yajuan; Zhao, Bo

doi:10.1016/j.cplett.2019.136657

Cited by 15 publications

(11 citation statements)

References 19 publications

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“…In the case of indirect immunoassays, the quantitative analysis of antigens is carried out by measuring the changes in electrochemical signal due to the conjugation of a labeled secondary antibody with the primary antibody which is already bound to antigen [75]. The design of indirect immunoassay follows two-step binding strategies in which the primary label-free antibody binds to In the case of indirect immunoassays, the quantitative analysis of antigens is carried out by measuring the changes in electrochemical signal due to the conjugation of a labeled secondary antibody with the primary antibody which is already bound to antigen [75]. The design of indirect immunoassay follows two-step binding strategies in which the primary label-free antibody binds to antigen which is first immobilized on the substrate.…”

Section: Ecbs Operating Through Bioaffinitymentioning

confidence: 99%

Section: Electrochemical Biosensorsmentioning

confidence: 99%

“…Typically, different labeled secondary antibodies compete to bind with inadequately available primary antibody sites. AuNP-modified electrodes have been utilized for the detection of phenolic estrogens through indirect competitive binding processes [ 75 ]. The four phenolic estrogens conjugated with the secondary antibody and the binding affinity followed: diethylstilbestrol > dienestrol > bisphenol A > hexestrol.…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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With the rise in public health awareness, research on point-of-care testing (POCT) has significantly advanced. Electrochemical biosensors (ECBs) are one of the most promising candidates for the future of POCT due to their quick and accurate response, ease of operation, and cost effectiveness. This review focuses on the use of metal nanoparticles (MNPs) for fabricating ECBs that has a potential to be used for POCT. The field has expanded remarkably from its initial enzymatic and immunosensor-based setups. This review provides a concise categorization of the ECBs to allow for a better understanding of the development process. The influence of structural aspects of MNPs in biocompatibility and effective sensor design has been explored. The advances in MNP-based ECBs for the detection of some of the most prominent cancer biomarkers (carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), Herceptin-2 (HER2), etc.) and small biomolecules (glucose, dopamine, hydrogen peroxide, etc.) have been discussed in detail. Additionally, the novel coronavirus (2019-nCoV) ECBs have been briefly discussed. Beyond that, the limitations and challenges that ECBs face in clinical applications are examined and possible pathways for overcoming these limitations are discussed.

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Section: Ecbs Operating Through Bioaffinitymentioning

confidence: 99%

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Section: Electrochemical Biosensorsmentioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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“…Immunosensors combining immunochemical reactions based on the antibody (Ab)-antigen (Ag) recognition with an appropriate electrochemical transducer provide significant advantages for bioanalysis, including cost-effectiveness, low reagent and sample volume, portability, high-specificity and sensitivity, and high-throughput analysis [ 76 ]. Immunosensors have applications in various fields of analysis, such as clinical medicine [ 77 , 78 ], environmental pollutant evaluation [ 79 , 80 , 81 ], food inspection [ 82 , 83 ], and pathogenic microorganism detection [ 84 , 85 ]. The incorporation of MXenes in the fabrication of immunosensors provide opportunities for increasing bioactivity of immobilized Abs on electrode surfaces, increasing surface area, and improving detection sensitivity.…”

Section: Classes Of Bioanalytical Sensors Based On Mxenesmentioning

confidence: 99%

MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications

Khan

Andreescu

2020

Sensors

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MXenes are recently developed 2D layered nanomaterials that provide unique capabilities for bioanalytical applications. These include high metallic conductivity, large surface area, hydrophilicity, high ion transport properties, low diffusion barrier, biocompatibility, and ease of surface functionalization. MXenes are composed of transition metal carbides, nitrides, or carbonitrides and have a general formula Mn+1Xn, where M is an early transition metal while X is carbon and/or nitrogen. Due to their unique features, MXenes have attracted significant attention in fields such as clean energy production, electronics, fuel cells, supercapacitors, and catalysis. Their composition and layered structure make MXenes attractive for biosensing applications. The high conductivity allows these materials to be used in the design of electrochemical biosensors and the multilayered configuration makes them an efficient immobilization matrix for the retention of activity of the immobilized biomolecules. These properties are applicable to many biosensing systems and applications. This review describes the progress made on the use and application of MXenes in the development of electrochemical and optical biosensors and highlights future needs and opportunities in this field. In particular, opportunities for developing wearable sensors and systems with integrated biomolecule recognition are highlighted.

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“…24 Futhermore, metal nanomaterials have been widely used in electrochemical immunosensors. 25 Currently, little research has been focused on the detection of phenolic oestrogens by electrochemical immunosensors.…”

Section: Introductionmentioning

confidence: 99%

Detection of four phenolic oestrogens by a novel electrochemical immunosensor based on a hexestrol monoclonal antibody

et al. 2020

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Design of nanogold electrochemical immunosensor for detection of four phenolic estrogens

Cited by 15 publications

References 19 publications

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications

Detection of four phenolic oestrogens by a novel electrochemical immunosensor based on a hexestrol monoclonal antibody

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