Design of nanoengineered antibacterial polymers for biomedical applications

Borjihan, Qinggele; Dong, Alideertu

doi:10.1039/d0bm00788a

Cited by 38 publications

(25 citation statements)

References 130 publications

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“…The dramatic increase of antibiotic-resistant bacteria is one of the biggest threats to global health [ 1 ]. The development of innovative antibiotic-free antibacterials is, in fact, one of the most important challenges of material scientists [ 2 , 3 ]. Two promising alternatives to antibiotics are the use of silver nanoparticles (AgNPs) and probiotics.…”

Section: Mainmentioning

confidence: 99%

Two-Sided Antibacterial Cellulose Combining Probiotics and Silver Nanoparticles

et al. 2021

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The constant increase of antibiotic-resistant bacteria demands the design of novel antibiotic-free materials. The combination of antibacterials in a biocompatible biomaterial is a very promising strategy to treat infections caused by a broader spectrum of resistant pathogens. Here, we combined two antibacterials, silver nanoparticles (AgNPs) and living probiotics (Lactobacillus fermentum, Lf), using bacterial cellulose (BC) as scaffold. By controlling the loading of each antibacterial at opposite BC sides, we obtained a two-sided biomaterial (AgNP-BC-Lf) with a high density of alive and metabolically active probiotics on one surface and AgNPs on the opposite one, being probiotics well preserved from the killer effect of AgNPs. The resulting two-sided biomaterial was characterized by Field-Emission Scanning Electron Microscopy (FESEM) and Confocal Laser Scanning Microscopy (CLSM). The antibacterial capacity against Pseudomonas aeruginosa (PA), an opportunistic pathogen responsible for a broad range of skin infections, was also assessed by agar diffusion tests in pathogen-favorable media. Results showed an enhanced activity against PA when both antibacterials were combined into BC (AgNP-BC-Lf) with respect to BC containing only one of the antibacterials, BC-Lf or AgNP-BC. Therefore, AgNP-BC-Lf is an antibiotic-free biomaterial that can be useful for the therapy of topical bacterial infections.

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Section: Mainmentioning

confidence: 99%

Two-Sided Antibacterial Cellulose Combining Probiotics and Silver Nanoparticles

et al. 2021

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“…[4] At present, the development of antibacterial agents is not fast enough to catch up with the development of bacterial resistance. [5] Therefore, it is urgent to develop a new and effective antibacterial agent that can effectively eradicate bacteria.…”

Section: Introductionmentioning

confidence: 99%

SnS Nanosheets for Rapid and Effective Bacteria Sterilization Under Near‐infrared Irradiation

Kim

Zhang

Sun

et al. 2021

Chemistry A European J

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Today, the threat of pathogenic bacterial infection worldwide that leads to the increase of mortality rate strongly demands the development of new antibacterial agents that can kill bacteria quickly and effectively. Although there are a lot of antibacterial agents that have been developed so far, few studies on the antibacterial performance of SnS have been investigated at 808 nm laser. Here, we synthesized SnS nanosheets with strong near-infrared absorption performance and excellent antibacterial performance via a simple solvothermal synthesis route. The as-prepared SnS nanosheets showed excellent photothermal conversion efficiency (38.7 %), photodynamic performance, and photostability, and at the same time 99.98 % and 99.7 % sterilization effect against Gram-negative Escherichia coli (E. coli) and Grampositive Bacillus subtilis (B. subtilis) under near-infrared irradiation (808 nm, 1.5 W/cm 2 ). This study suggests that SnS nanosheets could be a promising candidate for antibacterial therapy owing to the synergetic effects of photothermal and photodynamic performance.

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“…To date, various studies have been conducted to inhibit the formation of bacterial biolms. 10,11 Some approaches include exploration of specic technologies that disrupt bacterial growth through the transmission of shock waves/sound waves, induction of physical damage to the bacterial membrane using the sharp edge of a nano-wall, and usage of chemical treatment to destroy bacterial membrane permeability. [12][13][14] Minerals used as antibacterial agents can demonstrate various functions depending on the source and content, and can even play a novel role depending on the combination ratio of elements included in the composition.…”

Section: Introductionmentioning

confidence: 99%