Design of Multi‐Shelled Hollow Cr₂O₃Spheres for Metabolic Fingerprinting

Abstract

Schizophrenia (SZ) detection enables effective treatment to improve the clinical outcome, but objective and reliable SZ diagnostics are still limited. An ideal diagnosis of SZ suited for robust clinical screening must address detection throughput, low invasiveness, and diagnosis accuracy. Herein, we built a multi‐shelled hollow Cr2O3 spheres (MHCSs) assisted laser desorption/ionization mass spectrometry (LDI MS) platform for the direct metabolic profiling of biofluids towards SZ diagnostics. The MHCSs displayed strong light absorption for enhanced ionization and microscale surface roughness with stability for the effective LDI of metabolites. We profiled urine and serum metabolites (≈1 μL) with the enhanced LDI efficacy in seconds. We discriminated SZ patients (SZs) from healthy controls (HCs) with the highest area under the curve (AUC) value of 1.000 for the blind test. We identified four compounds with optimal diagnostic power as a simplified metabolite panel for SZ and demonstrated the metabolite quantification for clinic use. Our approach accelerates the growth of new platforms toward a precision diagnosis in the near future.

Automation and Standardization—A Coupled Approach towards Reproducible Sample Preparation Protocols for Nanomaterial Analysis

“…Therefore, great efforts were made to integrate multiple laboratory steps, minimize sample consumption, and increase the analysis speed and data precision which can be realized by microfluidic technology [48]. Establishing new protocols using tailored nanomaterials can help to minimize the preparation due to the enhancement in the detection [49][50][51][52][53]. Furthermore, the use of nanomaterials in such important fields stresses the significance of fast and reliable nano-analytics.…”

“…Minimization of the analytical equipment with lab-on-achip technology enables fast, sensitive, and selective detection and minimizes the amount of needed sample material [53]. Machine learning allows computer-aided fingerprinting and multi-modal recognition integrating constraints for a fast screening of the samples [50][51][52][53][54].…”

Synthesis and Spectrophotometric Analysis of Microcapsules Containing Immortelle Essential Oil

“…In the last 10 years, microencapsulation has been intensively researched for the medical, bio-medical, agricultural, food, cosmetic, and textile industries [1][2][3][4][5]. Produced micro/nano particles has great contribution to science and economy [2][3][4][5].…”

“…In the last 10 years, microencapsulation has been intensively researched for the medical, bio-medical, agricultural, food, cosmetic, and textile industries [1][2][3][4][5]. Produced micro/nano particles has great contribution to science and economy [2][3][4][5]. Microencapsulation is a process where a functional barrier is established between the core and the wall material to avoid chemical and physical reactions and to preserve the biological, functional and physicochemical properties of the core material [6,7].…”

“…Numerous techniques for microencapsulation are available depending on the nature of the encapsulated substance and on the type of polymer used [9,10]. A widely used method for the encapsulation of water insoluble substances within water insoluble polymers is the solvent removal method [2,[11][12][13][14][15]. Generally, the resulting product of the microencapsulation process is called a "microcapsule".…”