Design of Multi-Component Reactions

An Efficient and Convenient Procedure for the One-Pot Synthesis of α-Aminophosphonates from Aryl Azides under Solvent-Free Conditions

“…The product 4a was obtained in low yield in 10 hours when iron was not added (entry 1). Product 4a was obtained in better yields within shorter times when the amount of iron was increased (entries [2][3][4][5]. The best result was obtained with 84% yield of 4a in 8 minutes when 100 mol% of iron was added (entry 5).…”

“…The above results are in accord with the reported literature that the imine is the key intermediate in the product-forming pathway. 11n,o,17 As can be see in Scheme 2, reaction (2) is faster than reaction (3), so the intermediate imine was synthesized by reaction (2) in this multicomponent reaction. Iodine played the main role as the catalyst in the next step.…”

β-cyclodextrin-polyurethane polymer: A neutral and eco-friendly heterogeneous catalyst for the one-pot synthesis of 1,4-dihydropyridine and polyhydroquinolien derivatives via Hantzsch reaction under solvent-free conditions

“…In recent years, the development of new multicomponent reactions (MCRs) and the improvement of known MCRs are important areas of research in organic, combinatorial and medicinal chemistry. [1][2][3] As opposed to the classical route to synthesize complex molecules by sequential synthesis, MCRs allow the assembly of complex molecules in one-pot and offer a facile execution, high atom-economy and high selectivity and yields. [4][5][6][7] Dihydropyridines and their derivatives (DHPs) have received considerable attention of synthetic and medicinal chemists because of their broad spectrum of 402 KIASAT, NAZARI and DAVARPANAH biological and pharmaceutical activities.…”

Ultrasound-promoted, rapid, green, one-pot synthesis of 2′-aminobenzothiazolomethylnaphthols via a multi-component reaction, catalyzed by heteropolyacid in aqueous media

“…By minimizing the number of synthetic operations while maximizing the build-up of structural and functional complexities, these reactions are particularly appealing in the context of target-oriented synthesis (Mironovo, 2006;Shestopalov et al, 2008;Toure´and Hall, 2009;Zhang and Zhang, 2009;Zhu and Bienayme, 2005).…”