Design of molecularly imprinted hydrogels with thermoresponsive drug binding sites

Abstract

Drug delivery systems (DDS) regulate the spatiotemporal distribution of drugs in vivo to maximize efficacy and minimize side effects. Stimuli-responsive hydrogels, which exhibit a drastic change in volume in response...

Controllable Catalytic Activity of Temperature-Responsive Polymer Hybrid Microgels Designed Using a Gold Nanoparticle Monomer with Polymerizable Groups

“…The transmittances of PNIPAAm−AuNP hybrid microgels and PNIPAAm/AuNP mixtures in water decreased sharply at 34 °C (Figure 5), which is close to the LCST of PNIPAAm. 24,34,38 In addition, we examined the diameter and PDI of the PNIPAAm−AuNP hybrid microgels in water at various temperatures by DLS (Figure 6). From the correlation function of light scattering obtained by the DLS measurements (Figure S13), the diameter and PDI were calculated using the cumulant method, and the size distribution was obtained via the Marquardt analysis.…”

“…It is soluble and insoluble in water at temperatures below and above its LCST of 32 °C, respectively. This is because its polymer chain is hydrophilic and hydrophobic at temperatures below and above 32 °C, respectively. ,, PNIPAAm-based gels and particles exhibit reversible temperature-responsive swelling/shrinking behavior, and they change the diffusivity of molecules within their networks in an aqueous solution; hence, drug release from these gels and particles can be regulated in response to a change in temperature. ,− We have reported temperature-responsive interpenetrating polymer networks composed of PNIPAAm and hydrophilic alginate that can harvest liquid water from the air by a drastic change in their hydrophilicity in response to a temperature change …”

Imprinting of nanoparticles in thin films: Quo Vadis?

“…The motivation to imprint the above mentioned biological entities or NPs has been primarily for the development of a lowcost and fast platform for different applications such as separation, sensing, etc [64][65][66][67][68] . However, the urge for imprinting with higher dimensions poses difficulties in the extraction and rebinding steps, as a result of the relatively lower diffusion of the large object as compared with molecules.…”

Effect of Gold Nanoparticle Size on Regulated Catalytic Activity of Temperature-Responsive Polymer−Gold Nanoparticle Hybrid Microgels

“…Responsive polymers have attractive functions, such as natural feedback systems, capable of drastic changes in their structures and properties, such as conformation and hydrophilicity, in response to stimuli. Various responsive polymers, gels, and particles have been strategically designed owing to their versatile applications and unique abilities to respond to various external stimuli [ 34 , 35 ], such as temperature [ 26 , 30 , 36 , 37 ], biomolecules [ 38 , 39 , 40 ], and multiple stimuli such as ions, pH, light, and temperature [ 41 , 42 , 43 , 44 ]. Combining AuNPs with stimuli-responsive polymers allows us to control their properties, stability in aqueous media, and recovery using stimuli, such as temperature and light.…”