Design of mixing in microfluidic liquid slugs based on a new dimensionless number for precise reaction and mixing operations

Tanthapanichakoon, Wiroon; Aoki, Nobuaki; Matsuyama, Kiichi; Mae, Kazuhiro

doi:10.1016/j.ces.2006.01.047

Cited by 64 publications

(49 citation statements)

References 35 publications

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“…The micromixing efficiency in the liquid slug was dependent on the length and the velocity of the liquid slug, and the initial distribution of reactants. These experimental results were similar to the numerical simulation results of Tanthapanichakoon et al 54 They reported the mixing characteristics inside a microfluidic liquid slug of immiscible liquid-liquid two phases using the computational fluid dynamics (CFD) simulations. Their simulation results provided insights into the influences of operating parameters on the rate of slug-based mixing (such as initial arrangement of reactants in liquid slugs, slug velocity and slug diameter), and Peclet number of liquid slugs (Pe ¼ U S d 2 Diff /l S D) for estimating mixing rates and designing liquid slugs was proposed based on the simulation results.…”

Section: Modified Peclet Number For Micromixedness Ratiosupporting

confidence: 79%

“…Furthermore, the separation of the gas-liquid two phases after the outlet of microchannel is much easier than that of the immiscible liquid-liquid two phases because of larger density difference between the gasliquid two phases. Actually, the Peclet number proposed by Tanthapanichakoon et al 54 was the ratio of the diffusive time scale (t Diff ¼ d 2 Diff /D), to the convective transport time scale (t Conv ¼ l S / U S ) in liquid slugs, where d Diff was the diffusion distance and considered to be equal to the hydraulic diameter of the microchannel. When the Peclet number was less than a constant value, the mixing in liquid slugs was controlled by the molecular diffusion, or else, it was determined by the convective transport.…”

Section: Modified Peclet Number For Micromixedness Ratiomentioning

confidence: 99%

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Influence of hydrodynamics on liquid mixing during Taylor flow in a microchannel

Chen

Yuan

2011

AIChE Journal

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in Wiley Online Library (wileyonlinelibrary.com).The miscible liquid-liquid two phases based on Taylor flow in microchannels was investigated by high-speed imaging techniques and Villermaux/Dushman reaction. The mixing based on Taylor flow was much better compared with that without introducing gas in microchannels, even the ideal micromixing performance could be obtained under optimized superficial gas and liquid velocities. In the mixing process based on Taylor flow, the superficial gas and liquid velocities affected the lengths and the velocities of Taylor bubble and liquid slug, and finally the micromixing performance. The formation process of Taylor flow in the inlets, the initial uniform distribution of reactants and the internal circulations in the liquid slug, and the thin liquid films all improved the mixing performance. Furthermore, a modified Peclet number that represented the relative importance of diffusion and convection in the mixing process was proposed for explaining and anticipating micromixing efficiency.

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Section: Modified Peclet Number For Micromixedness Ratiosupporting

confidence: 79%

Section: Modified Peclet Number For Micromixedness Ratiomentioning

confidence: 99%

Influence of hydrodynamics on liquid mixing during Taylor flow in a microchannel

Chen

Yuan

2011

AIChE Journal

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“…In order to investigate such a problem, Sarazin et al [55] considered two kinds of methods in coalescing two droplets of different species subjected to mixing, i.e., coalescing in a longitudinal arrangement and in a side-by-side arrangement. As shown in Figure 27, coalescence of droplets in a longitudinal arrangement provides a much better mixing effect, which is in line with the studies of Tanthapanichakoon et al [53] and Wang et al [54]. As a carrier, fluid oil is most frequently used.…”

Section: Mixing By Dropletssupporting

confidence: 72%

“…When estimating the mixing performance in terms of the distribution of species concentration, care must be given to the initial condition concentration distribution. Tanthapanichakoon et al [53] numerically revealed that the initial concentrations is the most dominant parameter affecting the mixing rate, which was also addressed in the work of Wang et al [54]. This means that the given flow field inside the droplet keeps a symmetric property.…”

Section: Mixing By Dropletsmentioning

confidence: 82%

A Review on Mixing in Microfluidics

2010

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Small-scale mixing is of uttermost importance in bio-and chemical analyses using micro TAS (total analysis systems) or lab-on-chips. Many microfluidic applications involve chemical reactions where, most often, the fluid diffusivity is very low so that without the help of chaotic advection the reaction time can be extremely long. In this article, we will review various kinds of mixers developed for use in microfluidic devices. Our review starts by defining the terminology necessary to understand the fundamental concept of mixing and by introducing quantities for evaluating the mixing performance, such as mixing index and residence time. In particular, we will review the concept of chaotic advection and the mathematical terms, Poincare section and Lyapunov exponent. Since these concepts are developed from nonlinear dynamical systems, they should play important roles in devising microfluidic devices with enhanced mixing performance. Following, we review the various designs of mixers that are employed in applications. We will classify the designs in terms of the driving forces, including mechanical, electrical and magnetic forces, used to control fluid flow upon mixing. The advantages and disadvantages of each design will also be addressed. Finally, we will briefly touch on the expected future development regarding mixer design and related issues for the further enhancement of mixing performance.

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“…This circular convection is very efficient for the fast transport of particles and molecules and is of particular importance for mixing processes with vesicles, sensor particles, and cells, which are too large to show a significant diffusive contribution to their transport. The segment-internal convection supports the mixing after addition of components into segments (mixing, dosing) as well as homogenization during further procedures [12].…”

Section: Introductionmentioning

confidence: 99%

Investigation of mixture toxicity of widely used drugs caffeine and ampicillin in the presence of an ACE inhibitor on bacterial growth using droplet-based microfluidic technique

Cao

Goldhan

Martin

et al. 2013

Green Processing and Synthesis

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Droplet-based microfluidic technique is very suitable for a variety of screening processes. The cultivation within nanoliter segments and multidimensional microtoxicological screening of the Gram-negative bacterium Escherichia coli were studied under droplet-based microfluidic conditions. In order to evaluate the toxicity of the binary and ternary mixtures of antibiotic ampicillin and caffeine in the presence of the angiotensin-converting enzyme inhibitor captopril, a time-resolved optical double endpoint detection unit was applied. It included a microflow-through fluorimeter and photometer, which can simultaneously analyze changes in the endogenous autofluorescence signal and the cell density of E. coli cultivated inside 450-nl microfluid segments. As a result, strong nonlinear combination effects and a concentration-dependent antagonistic effect, as well as formation of activity summits on bolographic maps, were found. Our findings confirm the importance of multiparameter investigations for toxicological studies and could be taken into account in medical practice.

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Design of mixing in microfluidic liquid slugs based on a new dimensionless number for precise reaction and mixing operations

Cited by 64 publications

References 35 publications

Influence of hydrodynamics on liquid mixing during Taylor flow in a microchannel

Influence of hydrodynamics on liquid mixing during Taylor flow in a microchannel

A Review on Mixing in Microfluidics

Investigation of mixture toxicity of widely used drugs caffeine and ampicillin in the presence of an ACE inhibitor on bacterial growth using droplet-based microfluidic technique

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