Design of intelligent chitosan/heparin hollow microcapsules for drug delivery

Sun, Lili; Xiong, Xin; Zou, Qiaogen; Ouyang, Pingkai; Burkhardt, Claus; Krastev, Rumen

doi:10.1002/app.44425

Cited by 20 publications

(11 citation statements)

References 49 publications

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“…In our previous work, the deposition of Hep and Chi in acid solutions on calcium carbonate (CaCO 3 ) templates has been achieved successfully. The LbL‐assembled hollow capsules have been readily constructed by alternating deposition of synthetic and biodegradable polyelectrolytes on the CaCO 3 templates.…”

Section: Introductionmentioning

confidence: 99%

Controlled heparinase‐catalyzed degradation of polyelectrolyte multilayer capsules with heparin as responsive layer

Sun

Xiong

Zou

et al. 2017

J of Applied Polymer Sci

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This work describes the enzymatic degradation of combined hollow capsules via layer-by-layer (LbL) self-assembly technique. They previously showed the build-up and characterization of capsules composed of synthetic [Poly(sodium 4-styrene-sulfonate)/Poly(allylamine hydrochloride)] and biodegradable (Heparin/Chitosan) polyelectrolytes. Biocatalytic response of assembled multilayer capsules provides a more functional and oriented approach in controlled release of encapsulated molecules: in this case multilayer capsule was disassembled by heparinase. Morphological change of individual capsule was assessed with Atomic Force Microscopy and Confocal Laser Scanning Microscopy. The sustained release of encapsulated FITC-Dextran model was realized under enzymatic degradation of the capsule shells by heparinase. The release profile of FITC-Dextran indicated the successful control in a concentration-dependent manner, which shows the applicability as smart drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Controlled heparinase‐catalyzed degradation of polyelectrolyte multilayer capsules with heparin as responsive layer

Sun

Xiong

Zou

et al. 2017

J of Applied Polymer Sci

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“…Despite this slight drawback, they present numerous advantages due to their little-to-no toxicity, ease of biodegradability, and intrinsic biocompatibility [94]. Polysaccharides (typically glycosaminoglycans [95,96], functionalised chitosans [96,97], alginates [29,98], etc.) and polyamino acids (poly-L-glutamic acid (PGLU), poly-L-lysine (PLL), etc.)…”

Section: The Classification Of Sacraficial Templates and Issues Of Biocompatabilitymentioning

confidence: 99%

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

Vikulina

Campbell

2021

Nanomaterials

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One of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and other bioapplications. Biocompatibility, biodegradability, the possibility of replicating natural cellular microenvironments, and the minimal toxicity typical of biogenic polymers are features that have secured a growing interest in them as the building blocks for biomaterials of the fourth generation. Many recent studies showed the promise of the hard-templating approach for the fabrication of nano- and microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules and beads, critically assessing the progress made in this field of research, and outlining the current challenges and perspectives of these architectures. According to the classification of the templates, the review sequentially considers biopolymer structures templated on non-porous particles, porous particles, and crystal drugs. Opportunities for the functionalization of biopolymer-based capsules to tailor them toward specific bioapplications is highlighted in a separate section.

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“…The aforementioned vaterite CaCO 3 crystals are widely used as sacrificial cores for the fabrication of PEMCs [ 37 , 38 , 39 ] as well as larger tailor-made polymer based structures like porous polymer scaffolds [ 40 , 41 , 42 , 43 ]. The vaterite polymorph belongs to a family of naturally derived minerals [ 44 ], but can be readily produced from low-cost precursor salts (e.g., sodium carbonate and calcium chloride) at either the micro- or nanoscale [ 45 , 46 ].…”

Section: The Development Of Polyelectrolyte Multilayer Capsules (Pmentioning

confidence: 99%

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

2020

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Polyelectrolyte multilayer capsules (PEMCs) templated onto biocompatible and easily degradable vaterite CaCO3 crystals via the layer-by-layer (LbL) polymer deposition process have served as multifunctional and tailor-made vehicles for advanced drug delivery. Since the last two decades, the PEMCs were utilized for effective encapsulation and controlled release of bioactive macromolecules (proteins, nucleic acids, etc.). However, their capacity to host low-molecular-weight (LMW) drugs (<1–2 kDa) has been demonstrated rather recently due to a limited retention ability of multilayers to small molecules. The safe and controlled delivery of LMW drugs plays a vital role for the treatment of cancers and other diseases, and, due to their tunable and inherent properties, PEMCs have shown to be good candidates for smart drug delivery. Herein, we summarize recent progress on the encapsulation of LMW drugs into PEMCs templated onto vaterite CaCO3 crystals. The drug loading and release mechanisms, advantages and limitations of the PEMCs as LMW drug carriers, as well as bio-applications of drug-laden capsules are discussed based upon the recent literature findings.

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Design of intelligent chitosan/heparin hollow microcapsules for drug delivery

Cited by 20 publications

References 49 publications

Controlled heparinase‐catalyzed degradation of polyelectrolyte multilayer capsules with heparin as responsive layer

Controlled heparinase‐catalyzed degradation of polyelectrolyte multilayer capsules with heparin as responsive layer

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

Encapsulation of Low-Molecular-Weight Drugs into Polymer Multilayer Capsules Templated on Vaterite CaCO3 Crystals

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