Design of imprinting matrix for dual template sensing via electropolymerized polythiophene films

Abstract

This work presents the design of 3-thiophene acetic acid (3-TAA) polymer matrix based molecularly imprinted polymer (MIP)/reduced graphene oxide (RGO) composite for sensitive and selective detection of antipyrine (AnP) and ethionamide (ETH) simultaneously. Dual drug embedded molecularly imprinted polymer (MIP) based electrochemical sensor was developed via electropolymerization of 3-TAA. AnP and ETH were embedded inside a polymer matrix based on their 3-D orientation and interaction(s) with functional monomer(s). Their extraction from polymeric matrix generates cavities complimentary to shape and size of AnP and ETH. The extraction of templates was confirmed by differential pulse voltammetry (DPV) as well as highperformance liquid chromatography (HPLC). The designed sensor selectively captures and produces the electrochemical signal for imprinted drugs. The electrochemical behaviour of AnP and ETH was investigated by DPV technique. The sensitivity forboth drug molecules was commendable on a single polymeric composite with RGO on GC electrode (LOD of 0.117 μM for AnP and 0.15 μM for ETH). Also, the sensor exhibited excellent selectivity towards AnP and ETH in the presence of other analogous interferent molecules. Thus, the designed sensor showed high sensitivity as well as high selectivity for imprinted dual drug molecules on a single platform.

Research progress and perspectives in field‐induced imprinted polymers

“…Singh et al 71 produced a double-template imprinted polymer by adopting CV. In the preparation, antipyrine (AnP) and ethylthiamine (ETH) was used as template substances, 3-thiopheneacetic acid In the polymer preparation, high-energy radiation has been mostly applied in radiation cross-linking, radiation degradation, radiation grafting, and preparation of nanoparticles.…”

“…Singh et al 71 produced a double‐template imprinted polymer by adopting CV. In the preparation, antipyrine (AnP) and ethylthiamine (ETH) was used as template substances, 3‐thiopheneacetic acid (3‐TAA) as functional monomer, and reduced graphene oxide (RGO)‐modified GCE as working electrode at a scan rate of 50 mV/s with a voltage of 0.8 V applied during 10 cycles.…”

“…DPV response obtained at one‐day intervals over 7 days after 2 months in freezing conditions by MIP fabricate RGO/GCE sensor. Reproduced from Reference 71.…”