Design of human atherosclerosis studies by serial angiography

Brooks, Samuel H.; Blankenhorn, David H.; Chin, Hyunsook; Sanmarco, Miguel E.; Hanashiro, Paul K.; Selzer, Robert H.; Selvester, Ronald H.

doi:10.1016/0021-9681(80)90044-2

Cited by 26 publications

(6 citation statements)

References 16 publications

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“…Branch points on the femoral angiogram were marked and used for registration, duplicating the procedure used in pilot studies of replication. 19 Film digitization was carried out with a Joyce Loebl SCANDIG 3 rotating drum digitizer. In this instrument, a tungsten halogen lamp is mounted opposite a photodiode on an optical carriage that moves along the axis of the transparent rotating drum.…”

Section: Angiographic Analysismentioning

confidence: 99%

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Effects of colestipol-niacin therapy on human femoral atherosclerosis.

et al. 1991

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The 2-year therapy effect on femoral atherosclerosis was evaluated in the Cholesterol Lowering Atherosclerosis Study (CLAS), a randomized, placebo-plus-diet-controlled angiographic trial of colestipol-niacin therapy plus diet in men with previous coronary bypass surgery. Different diet compositions were prescribed to enhance the differential in blood cholesterol responses between the two groups. The annual rate of change in computer-estimated atherosclerosis (CEA), a measure of lumen abnormality, was evaluated between treatment groups. A significant per-segment therapy effect was found in segments with moderately severe atherosclerosis (p less than 0.04) and in proximal segments (p less than 0.02). When segmental CEA measures were combined into a per-patient score using an adaptation of the National Heart, Lung, and Blood Institute scoring procedure, a significant therapy effect was observed (p less than 0.02). Total variance of the annual change rate in CEA was as predicted from pilot studies, but measurement variation was larger. The therapy effect observed in femoral arteries, although significant, was less marked than the strong and consistent benefit previously reported for both native coronary arteries and aortocoronary bypass grafts.

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Section: Angiographic Analysismentioning

confidence: 99%

“…*Analysis using the modeling approach due to Rossner22 against a one-sided alternative. tCEA range: quartile 1 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), quartile 2 (28-35), quartile 3 (36-48), quartile 4 (49-180). groups (Figure 1).…”

Section: Per-patient Analysismentioning

confidence: 99%

Effects of colestipol-niacin therapy on human femoral atherosclerosis.

et al. 1991

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“…Several such quantitative methods have been investigated (5,6,12) to improve reproducibility. Analysis of computerized images with image processing of the femoral angiograms has been in use since 1986 in the Probucol Quantitative Regression Swedish Trial (PQRST) (15).…”

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confidence: 99%

Reproducibility of Quantitative Arteriographic Assessment of Atherosclerosis in the Femoral Artery

Bergstrand¹,

Erikson²,

Holme³

et al. 1993

Acta Radiol

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Results from computer-analysed angiograms in the Probucol Quantitative Regression Swedish Trial (PQRST) were analysed to determine the reproducibility of the method and any drift in the analysing system. The precision index (P(Il)) for 2 angiography series, made at 10 min intervals, of the femoral artery in 276 patients was 10.5 for lumen volume and 2\.9 for roughness (edge irregularity). No difference in reproducibility was found between patients with and without symptoms of peripheral atherosclerosis or when looking at the reproducibility over years. A drift of 0.67% per year in the radiographic equipment (but not in the analysis system) was found, confirmed by use of phantoms. Computer-based analysis of femoral atherosclerosis is a reliable method for follow-up trials, giving high reproducibility even if the trial spans over several years and involves different centres. The use of phantoms is essential for checking the method over time.

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“…From this array estimates of the arterial diameter, cross-sectional area and edge irregularity can be computed. A few clinical studies on digitized femoral arteriograms have been published (3,4,9), but most efforts in this field have been devoted to coronary cineangiograms (5,14,17,20,21). In order to detect changes in femoral artery atheroma volume over time, we have developed a method for estimating the femoral artery lumen volume.…”

mentioning

confidence: 99%