Design of fluorinated hyperbranched polyether copolymers for ¹⁹F MRI nanotheranostics

Abstract

19F MRI contrast agents and drug nanocarriers based on fluorinated hyperbranched polyether copolymers.

Weibull Modeling of Controlled Drug Release from Ag-PMA Nanosystems

“…Nowadays several efforts are focusing on the development of eco-friendly approaches to reduce the environmental impact of industrial production. To reach this goal, bottom-up techniques concerning the design of nanodevices able to efficiently perform one or more tasks [ 1 ] in the field of artificial photosynthesis [ 2 , 3 ], biomedicine [ 4 , 5 ], non-invasive diagnostic techniques [ 6 , 7 ], food packaging [ 8 , 9 ] are receiving ever-growing attention due to the versatility in the modulation of their properties. On the other hand, the use of biomaterials is crucial to preserve human and the ecosystem’s health.…”

Dendrimer Dynamics: A Review of Analytical Theories and Molecular Simulation Methods

“…5) can be clearly seen for ωτ1 < 1, while at higher ω, the power-law behavior of Equation ( 6) can clearly be seen. Finally, at very high ωτ1 (>10 6 for this linear chain), the results are not physically realistic, since G' and G" would probe the intramolecular dynamics at length and time scales smaller that of a single spring.…”

“…We feel that future experimental and theoretical work on these issues will eventually provide useful information for tuning the behavior of dendrimers, either in themselves or after suitable functionalization of the end units or, in some cases, also in their interior parts, for a wide range of applications ranging from drug delivery systems [ 3 ] to nucleic-acid transfection system [ 5 ] and theranostics [ 6 ] or nanomedicine, catalysis and molecular electronics [ 4 ]. The still growing interest in these highly branched molecules is also evident in most recent extensive reviews discussing, for instance dendrimer-based nanoparticles for cancer treatment as drug carriers through non-covalent encapsulation or bound to the functionalized ends [ 62 ], or dendrimers acting as electrochemical biosensors and sensors through functionalization of the free ends [ 63 ], and dendrimers having functionalized ends for the removal of contaminants in water environment [ 64 ].…”

“…Many applications in different fields are envisioned for these macromolecules, including drug delivery [ 3 ], catalysis, molecular electronics and nanomedicine [ 4 ], nucleic-acid transfection system [ 5 ] and theranostics [ 6 ]. However, their highly branched monodisperse structures with a well-defined and highly symmetrical geometry also provide stringent tests for analytical theories and molecular simulations to be compared with experimental data.…”

Intermolecular Forces Driving Hexamethylenetetramine Co-Crystal Formation, a DFT and XRD Analysis

“…One of the most effective strategies for enhancing the solubility of acid/basic drugs consists of the formation of salts, using an appropriate partner for the drug [ 1 ]. More recently explored possibilities consist of co-crystallize the active drug with another suitable component [ 2 ], drug delivery by a suitable carrier [ 3 , 4 ] or resort to the formation of polymorphs. It is nowadays well known that the arrangement adopted by species in their solid form brings a change of their physical-chemical properties and can have profound effects on the dissolution rate [ 5 , 6 ], stability, and bioavailability of that species.…”