“…Existing layout design procedures, whether for functional or cellular layouts, have been, for the most part, based on a deterministic paradigm, where design parameters, such as product mix, product demands, and product routings, are assumed to be all known with certainty [29,54,56,72]. The design criterion used in selecting layouts is often a static measure of material handling efficiency (i.e., a total adjacency score or total material handling distance) which does not capture the need for flexibility and reconfigurability in a dynamic environment [9,10,13,43]. In fact, the relationship between layout flexibility and layout performance remains poorly understood and analytical models for its evaluation are still lacking.…”