Design of experiments for green and GRAS solvent extraction of phenolic compounds from food industry by-products - A systematic review

López-Salas, Lucía; Expósito-Almellón, Xavier; Borrás-Linares, Isabel; Lozano-Sánchez, Jesús; Segura-Carretero, Antonio

doi:10.1016/j.trac.2024.117536

Cited by 3 publications

(1 citation statement)

References 89 publications

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“…Several studies have focused on the optimization of various extraction processes from different kinds of by-products from the food industry using surface response methodology (SRM) [ 21 , 22 , 23 , 24 ]. Furthermore, SRM allows us to analyze and process data from a response variable of interest that is influenced by different quantitative factors (independent variables) [ 25 ]. The main objective of SRM is to design an experiment that determines the specific values of the independent variables to elicit the desirable effect on the response variable.…”

Section: Introductionmentioning

confidence: 99%

Agave angustifolia Haw. Leaves as a Potential Source of Bioactive Compounds: Extraction Optimization and Extract Characterization

Bermúdez-Bazán,

Estarrón-Espinosa,

Castillo-Herrera

et al. 2024

Molecules

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The leaves of Agave angustifolia Haw. are the main agro-waste generated by the mezcal industry and are becoming an important source of bioactive compounds, such as phenolic compounds, that could be used in the food and pharmaceutical industries. Therefore, the extraction and identification of these phytochemicals would revalorize these leaf by-products. Herein, maceration and supercritical carbon dioxide (scCO2) extractions were optimized to maximize the phenolic and flavonoid contents and the antioxidant capacity of vegetal extracts of A. angustifolia Haw. In the maceration process, the optimal extraction condition was a water–ethanol mixture (63:37% v/v), which yielded a total phenolic and flavonoid content of 27.92 ± 0.90 mg EAG/g DL and 12.85 ± 0.53 µg QE/g DL, respectively, and an antioxidant capacity of 32.67 ± 0.91 (ABTS assay), 17.30 ± 0.36 (DPPH assay), and 13.92 ± 0.78 (FRAP assay) µM TE/g DL. Using supercritical extraction, the optimal conditions for polyphenol recovery were 60 °C, 320 bar, and 10% v/v. It was also observed that lower proportions of cosolvent decreased the polyphenol extraction more than pressure and temperature. In both optimized extracts, a total of 29 glycosylated flavonoid derivatives were identified using LC-ESI-QTof/MS. In addition, another eight novel compounds were identified in the supercritical extracts, showing the efficiency of the cosolvent for recovering new flavonoid derivatives.

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Section: Introductionmentioning

confidence: 99%

Agave angustifolia Haw. Leaves as a Potential Source of Bioactive Compounds: Extraction Optimization and Extract Characterization

Bermúdez-Bazán,

Estarrón-Espinosa,

Castillo-Herrera

et al. 2024

Molecules

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Adsorption of dihydroxybenzene isomers over Schiff-based network-1-derived nitrogen-enriched carbon: Effective and favorable adsorption of hydroquinone

Hossain,

Jhung

2025

Separation and Purification Technology

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Optimization of food-grade bioactive compound extraction from plant sources by response surface methodology approach: A comprehensive review

Karabegoić,

Stojanović,

Mančić

et al. 2023

Maso International – Journal of Food Science and Technology

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This comprehensive review delves into the extensive application of response surface methodology (RSM), a prominent mathematical and statistical technique, for modeling and optimizing the extraction of food-grade bioactive compounds from plant sources. The paper elucidates the optimization approach, covering experimental design, empirical models for response prediction, and the utilization of the desirability function for multiple response optimization. RSM provides a contemporary means to concurrently analyze and optimize various factors, presenting mathematical models for enhancing extraction processes efficiently. The review showcases RSM applications in traditional extraction techniques such as classical solvent extraction, Soxhlet extraction, and hydrodistillation, with a focus on factors like extraction time, temperature, ratio of plant material to solvent, and solvent concentration. The economic feasibility of RSM-optimized extraction processes is discussed, encompassing considerations of processing time, solvent consumption, and overall cost reduction. Critical aspects and challenges related to RSM implementation in extraction optimization are addressed, underscoring the significance of appropriate experimental design, model accuracy, and the incorporation of multiple responses for comprehensive optimization. The review concludes by emphasizing the pivotal role of RSM in guiding rational and efficient extraction processes for various valuable natural compounds from plant materials.

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Design of experiments for green and GRAS solvent extraction of phenolic compounds from food industry by-products - A systematic review

Cited by 3 publications

References 89 publications

Agave angustifolia Haw. Leaves as a Potential Source of Bioactive Compounds: Extraction Optimization and Extract Characterization

Agave angustifolia Haw. Leaves as a Potential Source of Bioactive Compounds: Extraction Optimization and Extract Characterization

Adsorption of dihydroxybenzene isomers over Schiff-based network-1-derived nitrogen-enriched carbon: Effective and favorable adsorption of hydroquinone

Optimization of food-grade bioactive compound extraction from plant sources by response surface methodology approach: A comprehensive review

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