Design of dipalmitoyl lecithin liposomes loaded with quercetin and rutin and their release kinetics from carboxymethyl cellulose edible films

Silva-Weiss, Andrea; Quilaqueo, Marcela; Venegas, O.; Ahumada, Manuel; Silva, W.; Osorio, Fernando; Giménez, Begoña

doi:10.1016/j.jfoodeng.2018.01.001

Cited by 62 publications

(22 citation statements)

References 35 publications

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“…The thin-film dispersion method was used to prepare BVP-LP [24,25,27,28]. 1.0 g phospholipid and 0.25 g cholesterol were accurately weighed and dissolved in absolute ethanol.…”

Section: Bvp-lpmentioning

confidence: 99%

“…They have a size range from ~20 nm to ~5 µm in diameter, with one or more lipid bilayers surrounding aqueous compartments [23]. Liposomes have several desirable properties, such as good biodegradability and biocompatibility, prolonged release effect and enhanced chemical stability of drugs [24][25][26][27][28][29][30][31]. Phospholipid complexes, also named phytosomes, are a novel drug delivery system formed by non-covalent bonds (electrostatic interaction, van der Waals force, hydrogen bond and etc.)…”

Section: Introductionmentioning

confidence: 99%

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Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes

et al. 2021

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Breviscapine (BVP), a flavonoid compound, is widely used in the treatment of cardiovascular and cerebrovascular diseases; however, the low oral bioavailability and short half-life properties limit its application. The aim of this study was to investigate the three preparations for improving its oral bioavailability: nanosuspensions (BVP-NS), liposomes (BVP-LP) and phospholipid complexes (BVP-PLC). In vitro and in vivo results suggested that these three could all significantly improved the cumulative released amount and oral bioavailability compared with physical mixture, in which BVP-PLC was the most optimal preparation with the relative bioavailability and mean retention time of 10.79 ± 0.25 (p < 0.01) and 471.32% (p < 0.01), respectively. Furthermore, the influence of drug-lipid ratios on the in vitro release and pharmacokinetic behavior of BVP-PLC was also studied and the results showed that 1:2 drug-lipid ratio was the most satisfactory one attributed to the moderate-intensity interaction between drug and phospholipid which could balance the drug loading and drug release very well.

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“…The thin-film dispersion method was used to prepare BVP-LP [24,25,27,28]. 1.0 g phospholipid and 0.25 g cholesterol were accurately weighed and dissolved in absolute ethanol.…”

Section: Bvp-lpmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes

et al. 2021

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“…To extend the functionality of cellulose derivative-based edible films, various antioxidant and antimicrobial components were incorporated in the system. For example, the biological activity of carboxymethyl cellulose films was improved by addition of dipalmitoyl lecithin liposomes loaded with quercetin and rutin [49], α-tocopherol [50], spent coffee ground polysaccharides [51], candelilla wax [52]. Dicastillo et al obtained high antioxidant activity of methyl cellulose/murta fruit extract and methyl cellulose/native Chilean berry extract films, which makes them suitable for food packaging of fatty food products [53,54].…”

Section: Cellulosementioning

confidence: 99%

Prospect of Polysaccharide-Based Materials as Advanced Food Packaging

Nešić

Cabrera‐Barjas

Dimitrijević-Branković

et al. 2019

Molecules

208

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The use of polysaccharide-based materials presents an eco-friendly technological solution, by reducing dependence on fossil resources while reducing a product's carbon footprint, when compared to conventional plastic packaging materials. This review discusses the potential of polysaccharides as a raw material to produce multifunctional materials for food packaging applications. The covered areas include the recent innovations and properties of the polysaccharide-based materials. Emphasis is given to hemicelluloses, marine polysaccharides, and bacterial exopolysaccharides and their potential application in the latest trends of food packaging materials, including edible coatings, intelligent films, and thermo-insulated aerogel packaging.

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“…Achieving an adequate controlled release of agents in active packaging is critical to keep active substance concentration above the minimum inhibitory concentration against pathogenic or spoilage microorganisms during product shelf-life (Franssen et al, 2004). From this point of view, different strategies have been suggested based on: multilayer films (Buonocore et al, 2004;Lopez-Rubio et al, 2006), smart bio-polymer blending (LaCoste et al, 2005), matrix crosslinking (Buonocore et al, 2003), encapsulation technology (Parris et al, 2005;Silva-Weiss et al, 2018;Tampau et al, 2018), and incorporation of various type of fatty acids (Arcan and Yemenicioğlu, 2014). Fatty acids have been also incorporated in zein films as plasticizers to overcome brittleness, poor process ability, low elongation, and to improve water barrier properties and visual appearance (Padua and Wang, 2002).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial packaging based on a LAE containing zein coating to control foodborne pathogens in chicken soup

Kashiri

López‐Carballo

Hernández‐Muñoz

et al. 2019

International Journal of Food Microbiology

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In this study, zein coatings containing Lauroyl-L-arginine ethyl ester monohydrochloride (LAE) were developed to be applied on polypropylene films and manufacture an active food packaging. The concentration of LAE and the addition of a suitable plasticizer (glycerol or oleic acid (OA)) were the main variables considered. Active plasticized zein films, with glycerol or oleic acid were characterized in terms of release kinetics, mechanical, barrier, optical, and antimicrobial properties. Results showed that active agent concentration, (5 and 10%), had no-significant effect on mechanical and WVP properties of the plasticized films. Films plasticized with OA presented greater water resistance, UV-light opacity, and water barrier properties than glycerol-plasticized films. On the contrary, the latter had better antimicrobial properties. The analysis of LAE release kinetics from films to different food simulants revealed different behaviours, depending on both film formulation and food simulant. Despite the lower water resistance of coatings containing glycerol, bags based on polypropylene/glycerol plasticized zein containing 10% of LAE presented a great antimicrobial activity in tests with chicken soup (real food system) contaminated with pathogen bacteria, concretely, the films showed 3.21 Log reduction against Listeria monocytogenes and 3.07 log reductions against Escherichia coli. These results suggest a promising strategy on the use of LAE-containing zein in active food packaging to control foodborne pathogens.

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Design of dipalmitoyl lecithin liposomes loaded with quercetin and rutin and their release kinetics from carboxymethyl cellulose edible films

Cited by 62 publications

References 35 publications

Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes

Improving Breviscapine Oral Bioavailability by Preparing Nanosuspensions, Liposomes and Phospholipid Complexes

Prospect of Polysaccharide-Based Materials as Advanced Food Packaging

Antimicrobial packaging based on a LAE containing zein coating to control foodborne pathogens in chicken soup

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