Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons
Nicholas L. Truex,
Somesh Mohapatra,
Mariane Melo
et al.
Abstract:Antigen processing
is critical for therapeutic vaccines to generate
epitopes for priming cytotoxic T cell responses against cancer and
pathogens, but insufficient processing often limits the quantity of
epitopes released. We address this challenge using machine learning
to ascribe a proteasomal degradation score to epitope sequences. Epitopes
with varying scores were translocated into cells using nontoxic anthrax
proteins. Epitopes with a low score show pronounced immunogenicity
due to antigen processing, but … Show more
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