Design of Culture Media

Gorfien, Stephen F.; Campbell, Andrew; Vemuri, Mohan C.

doi:10.1016/b978-0-08-088504-9.00028-3

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Generally, cell culture media contain energy sources, amino acids, vitamins, lipids, inorganic metals, salts, and buffering agents. These components are designed and balanced to present a physiological environment for the specific cell of interest [10]. The quality of the components used and the consistency of manufacture of these factors are critical to the performance of the medium.…”

Section: Processesmentioning

confidence: 99%

Concise Review: Guidance in Developing Commercializable Autologous/Patient-Specific Cell Therapy Manufacturing

Eaker¹,

Armant

Brandwein

et al. 2013

Stem Cells Translational Medicine

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Cell therapy is poised to play an enormous role in regenerative medicine. However, little guidance is being made available to academic and industrial entities in the start-up phase. In this technical review, members of the International Society for Cell Therapy provide guidance in developing commercializable autologous and patient-specific manufacturing strategies from the perspective of process development. Special emphasis is placed on providing guidance to small academic or biotech researchers as to what simple questions can be addressed or answered at the bench in order to make their cell therapy products more feasible for commercial-scale production. We discuss the processes that are required for scale-out at the manufacturing level, and how many questions can be addressed at the bench level. The goal of this review is to provide guidance in the form of topics that can be addressed early in the process of development to better the chances of the product being successful for future commercialization. STEM CELLS TRANSLATIONAL MEDICINE 2013;2: 871-883

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Section: Processesmentioning

confidence: 99%