Design of comb-like poly(2-methyl-2-oxazoline) and its rapid co-deposition with dopamine for the study of antifouling properties

Yan, Ye Han; Atif, Muhammad; Liu, Ren Yong; Zhu, Hai Kun; Chen, Li Juan

doi:10.1080/09205063.2019.1697169

Cited by 3 publications

(2 citation statements)

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“…To date, PEtOx appears to be the most investigated poly(2-oxazoline) in terms of biomedical applications [ 7 , 10 , 14 , 15 , 16 , 27 ], and PEtOx based polymer-drug conjugates and hemostatic materials have also reached human clinical trials [ 28 , 29 , 30 , 31 ]. Nonetheless, PMeOx is an important runner-up, and is especially attractive to shield drug carriers and for antifouling coatings based on its hydrophilicity, which is higher than that of PEtOx and PEG [ 17 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. It was shown that more hydrophilic PMeOx exhibits better anti-fouling properties than both PEtOx with longer side chains and PEG [ 32 , 33 , 34 , 35 , 36 , 37 , 38 ], and allows higher hydrophobic drug loading [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, PMeOx is an important runner-up, and is especially attractive to shield drug carriers and for antifouling coatings based on its hydrophilicity, which is higher than that of PEtOx and PEG [ 17 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. It was shown that more hydrophilic PMeOx exhibits better anti-fouling properties than both PEtOx with longer side chains and PEG [ 32 , 33 , 34 , 35 , 36 , 37 , 38 ], and allows higher hydrophobic drug loading [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

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Conformational Parameters and Hydrodynamic Behavior of Poly(2-Methyl-2-Oxazoline) in a Broad Molar Mass Range

et al. 2023

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In this work, we report our results on the hydrodynamic behavior of poly(2-methyl-2-oxazoline) (PMeOx). PMeOx is gaining significant attention for use as hydrophilic polymer in pharmaceutical carriers as an alternative for the commonly used poly(ethylene glycol) (PEG), for which antibodies are found in a significant fraction of the human population. The main focus of the current study is to determine the hydrodynamic characteristics of PMeOx under physiological conditions, which serves as basis for better understanding of the use of PMeOx in pharmaceutical applications. This goal was achieved by studying PMeOx solutions in phosphate-buffered saline (PBS) as a solvent at 37 °C. This study was performed based on two series of PMeOx samples; one series is synthesized by conventional living cationic ring-opening polymerization, which is limited by the maximum chain length that can be achieved, and a second series is obtained by an alternative synthesis strategy based on acetylation of well-defined linear poly(ethylene imine) (PEI) prepared by controlled side-chain hydrolysis of a defined high molar mass of poly(2-ethyl-2-oxazoline). The combination of these two series of PMeOx allowed the determination of the Kuhn–Mark–Houwink–Sakurada equations in a broad molar mass range. For intrinsic viscosity, sedimentation and diffusion coefficients, the following expressions were obtained: η=0.015M0.77, s0=0.019M0.42 and D0=2600M−0.58, respectively. As a result, it can be concluded that the phosphate-buffered saline buffer at 37 °C represents a thermodynamically good solvent for PMeOx, based on the scaling indices of the equations. The conformational parameters for PMeOx chains were also determined, revealing an equilibrium rigidity or Kuhn segment length, (A) of 1.7 nm and a polymer chain diameter (d) of 0.4 nm. The obtained value for the equilibrium rigidity is very similar to the reported values for other hydrophilic polymers, such as PEG, poly(vinylpyrrolidone) and poly(2-ethyl-2-oxazoline), making PMeOx a relevant alternative to PEG.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Conformational Parameters and Hydrodynamic Behavior of Poly(2-Methyl-2-Oxazoline) in a Broad Molar Mass Range

et al. 2023

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Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis

Zhang,

Cao

et al. 2023

Cell Mol Neurobiol

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This study employs bibliometric analysis through CiteSpace to comprehensively evaluate the status and trends of MANF (mesencephalic astrocyte-derived neurotrophic factor) research spanning 25 years (1997–2022). It aims to fill the gap in objective and comprehensive reviews of MANF research. MANF-related studies were extracted from the Web of Science database. MANF publications were quantitatively and qualitatively analyzed for various factors by CiteSpace, including publication volume, journals, countries/regions, institutions, and authors. Keywords and references were visually analyzed to unveil research evolution and hotspot. Analysis of 353 MANF-related articles revealed escalating annual publications, indicating growing recognition of MANF's importance. High-impact journals such as the International Journal of Molecular Sciences and Journal of Biological Chemistry underscored MANF’s interdisciplinary significance. Collaborative networks highlighted China and the USA’s pivotal roles, while influential figures and partnerships drove understanding of MANF's mechanisms. Co-word analysis of MANF-related keywords exposed key evolutionary hotspots, encompassing neurotrophic effects, cytoprotective roles, MANF-related diseases, and the CDNF/MANF family. This progression from basic understanding to clinical potential showcased MANF’s versatility from cellular protection to therapy. Bibliometric analysis reveals MANF’s diverse research trends and pathways, from basics to clinical applications, driving medical progress. This comprehensive assessment enriches understanding and empowers researchers for dynamic evolution, advancing innovation, and benefiting patients. Graphical Abstract Bibliometric analysis of MANF research. The graphical abstract depicts the bibliometric analysis of MANF research, highlighting its aims, methods, and key results.

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Simultaneous deposition of tannic acid derivative and covalent conjugation of poly(2-methyl-2-oxazoline) for the construction of antifouling coatings

Tang

Cheng

Huang

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Design of comb-like poly(2-methyl-2-oxazoline) and its rapid co-deposition with dopamine for the study of antifouling properties

Cited by 3 publications

References 40 publications

Conformational Parameters and Hydrodynamic Behavior of Poly(2-Methyl-2-Oxazoline) in a Broad Molar Mass Range

Conformational Parameters and Hydrodynamic Behavior of Poly(2-Methyl-2-Oxazoline) in a Broad Molar Mass Range

Navigating the Landscape of MANF Research: A Scientometric Journey with CiteSpace Analysis

Simultaneous deposition of tannic acid derivative and covalent conjugation of poly(2-methyl-2-oxazoline) for the construction of antifouling coatings

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