A fully integrated, low-power, low-noise OTA for Biosensor is proposed in this paper to detect biomedical signal using Implantable Health Devices. The proposed Operational Transconductance Amplifier is built basedon differential mirror circuit. The existing IMD detects a single disorder and consumes high power resulting in need of replacement within a period of time. The output of the proposed OTA is validated under a balanced low supply voltage by means of simulation results using 180 nm, 90 nm and 45nmCMOS technology. The proposed OTA absorbs power within the range of nano watts. Comparison with the designs mentioned in the article is based on gain, noise, location, transconductance, and bandwidth. The findings indicate substantial performance and improvement of the proposed OTA is related to previously published designs that are suitable for biomedical applications. The post layout simulation of the proposed integrated circuit was successfully performed.