Design of ciprofloxacin impregnated dietary fiber psyllium-moringa gum-alginate network hydrogels via green approach for use in gastro-retentive drug delivery system

Singh, Baljit; Sharma, Vikrant; Mohan, Man; Rohit, .; Sharma, Prerna; Ram, Kaka

doi:10.1016/j.bcdf.2022.100345

Cited by 3 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[108][109][110][111] Created with BioRender.com. [112] Psyllium moringa gum alginate Ciprofloxacin Hydrogel beads Anti ulcer potential "anti oxidative potential Slow and sustained drug delivery [113] Calcium alginate based sphere-in-capsule structure Bovine serum albumin Ranitidine hydrochloride…”

Section: Future Perspectivesmentioning

confidence: 99%

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

View full text Add to dashboard Cite

The pressing need for the development of diversified and non‐toxic biomaterials in recent decades has led to the emergence of novel and valuable structural modifications in polysaccharides to broaden their spectrum of applications. Polysaccharides are macromolecules with multifaceted diverse structures and exhibit wide range of pharmacological and biological activities. Naturally occurring polysaccharides such as starch, chitosan, alginate, acetalated dextran and pectin could potentially negate major concerns associated with the selection of suitable polysaccharides without compromising their unique bioactive nature. Chemical modification of polysaccharides offers distinctive benefits such as improved biocompatibility, stability, solubility, and functionality making them more valuable for a variety of biomedical applications such as drug delivery, gene delivery, cell culture technology and tissue engineering. The present review is a compendium of relevant chemically modified polysaccharides and discusses their role in diverse fields of pharmacy and medicine.

show abstract

Section: Future Perspectivesmentioning

confidence: 99%

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

View full text Add to dashboard Cite

show abstract

New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes

Gordeeva,

Sitenkova (Bukhovets),

Moustafine

2024

Sci. Pharm.

View full text Add to dashboard Cite

The aim of this study was the analysis of interpolyelectrolyte complexes (IPECs) based on Eudragit® EPO and Eudragit® L100 as prospective carriers for gastroretentive drug delivery systems (GRDDS) using two model drugs: metronidazole (MZ) and acyclovir (ACR). Eudragit® EPO/L100 IPECs with different pH concentrations were characterized by different degrees of swelling in mimicking fasted stomach medium (0.1 M HCl) and saved their shape for 6 h. The microenvironmental changes in IPEC structures in acidic medium were investigated using FT-IR spectroscopy, thermal and elemental analysis. IPEC samples showed bioadhesive properties that were not significantly different from the positive control (Carbopol) in the test with the mucin compacts. The release rate of metronidazole (class I BCS) from IPEC matrices increased with the increasing degree of swelling. IPEC 1 provided 49.62 ± 6.20% and IPEC 2 reached 87.69 ± 5.15% of metronidazole release after 6 h in mimicking fasted stomach medium (0.1 M HCl). The total amount of released acyclovir (class III BCS) from IPEC 1 was 25.76 ± 5.67% and from IPEC 2 was 21.48 ± 5.00%. Release of both drugs was controlled by relaxation of polymeric chains in matrices according to the Peppas–Sahlin model. According to the received results, investigated interpolymer complexes are prospects for further evaluation as carriers for gastroretentive bioadhesive systems.

show abstract

The contemplation of amylose for the delivery of ulcerogenic nonsteroidal anti-inflammatory drugs

Fatima,

Prasher,

Sharma

et al. 2024

Future Medicinal Chemistry

View full text Add to dashboard Cite

This manuscript proposes an innovative approach to mitigate the gastrointestinal adversities linked with nonsteroidal anti-inflammatory drugs (NSAIDs) by exploiting amylose as a novel drug delivery carrier. The intrinsic attributes of V-amylose, such as its structural uniqueness, biocompatibility and biodegradability, as well as its capacity to form inclusion complexes with diverse drug molecules, are meticulously explored. Through a comprehensive physicochemical analysis of V-amylose and ulcerogenic NSAIDs, the plausibility of amylose as a protective carrier for ulcerogenic NSAIDs to gastrointestinal regions is elucidated. This review further discusses the potential therapeutic advantages of amylose-based drug delivery systems in the management of gastric ulcers. By providing controlled release kinetics and enhanced bioavailability, these systems offer promising prospects for the development of more effective ulcer therapies.

show abstract

Design of ciprofloxacin impregnated dietary fiber psyllium-moringa gum-alginate network hydrogels via green approach for use in gastro-retentive drug delivery system

Cited by 3 publications

References 55 publications

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

New Carriers for Bioadhesive Gastroretentive Drug Delivery Systems Based on Eudragit® EPO/Eudragit® L100 Interpolyelectrolyte Complexes

The contemplation of amylose for the delivery of ulcerogenic nonsteroidal anti-inflammatory drugs

Contact Info

Product

Resources

About