Design of chitosan-based particle systems: A review of the physicochemical foundations for tailored properties

Ferreira, Leonardo Miziara Barboza; Santos, Aline Martins dos; Boni, Fernanda Isadora; Santos, Karen Cristina dos; Robusti, Leda Maria Gorla; Souza, Maurício Palmeira Chaves de; Ferreira, Natália Noronha; Carvalho, Suzana Gonçalves; Cardoso, Valéria M.O.; Chorilli, Marlus; Cury, Beatriz Stringhetti Ferreira; Godoi, Denis Ricardo Martins de; Gremião, Maria Palmira Daflon

doi:10.1016/j.carbpol.2020.116968

Cited by 46 publications

(20 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are mainly extracted from marine resources (shrimp shell and algal biomass, respectively). These biopolymers are very versatile both physically (elaborating different shaping and conditionings) and chemically (reactivity of functional groups for chemical reaction and grafting of specific reactive groups) [19][20][21][22][23][24]. Chitosan is characterized by the presence of hydroxyl groups (providing hydrophilic behavior) and amine groups, which are highly reactive for metal binding.…”

Section: Introductionmentioning

confidence: 99%

Recovery of Heavy Metal Ions Using Magnetic Glycine-Modified Chitosan—Application to Aqueous Solutions and Tailing Leachate

et al. 2021

View full text Add to dashboard Cite

The necessity of decontaminating effluents for the dual purpose of environmental beneficiation and valorization of low-grade resources is driving the development of new sorbents. The functionalization of biopolymers is a promising strategy for improving sorption performance. Incorporating magnetic micro-particles offers an opportunity for the facilitated recovery of spent micron-size sorbent. Combining magnetic facilities and biopolymer functionalization represents a winning strategy. Magnetic glycine-grafted chitosan (G@MChs) was synthesized for the sorption of Ni(II), Zn(II), and Hg(II) before being applied to the removal of hazardous and strategic metals from tailing leachates. The sorbent was characterized using Fourier transform infrared spectroscopy and scanning electron microscopy, before and after metal sorption. The acid–base properties of functionalized sorbent were also determined (pHPZC). Uptake kinetics were studied in mono- and multi-component solutions using different equations for kinetic modeling at optimized pH (i.e., pH0: 5.5). Langmuir and Sips equations were applied to model sorption isotherms in single-component solutions. In addition, sorption isotherms in multi-component solutions were used to evaluate the preference for selected metals. Maximum sorption capacities were 0.35 mmol Hg g−1, 0.47 mmol Zn g−1, and 0.50 mmol Ni g−1. Acidified urea solution (pH 2.7) successfully desorbs metal ions from G@MChs (desorption > 90%). The sorbent was tested for the recovery of hazardous and strategic metal ions from acidic leachates of tailings. This study demonstrates the promising performance of G@MChs for the treatment of complex metal-bearing solutions.

show abstract

Section: Introductionmentioning

confidence: 99%

Recovery of Heavy Metal Ions Using Magnetic Glycine-Modified Chitosan—Application to Aqueous Solutions and Tailing Leachate

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, PLGA is considered safe since it has good biocompatibility and no immunogenicity and is hydrolyzed to the non-toxic, biodegradable byproducts lactic acid and glycolic acid [ 84 ]. In particular, PLGA NPs coated with CS, thanks to their safety profile, good biocompatibility, and low levels of immunogenicity and toxicity, have been approved by regulatory agencies such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) as effective DDSs in humans [ 85 ]. An advantage of the CS backbone is that it can be modified by many functional groups.…”

Section: Ga-functionalized Polymer-based Ddssmentioning

confidence: 99%

Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy

et al. 2022

View full text Add to dashboard Cite

Liver cancer is one of the most common causes of cancer mortality worldwide. Chemotherapy and radiotherapy are the conventional therapies generally employed in patients with liver tumors. The major issue associated with the administration of chemotherapeutics is their high toxicity and lack of selectivity, leading to systemic toxicity that can be detrimental to the patient’s quality of life. An important approach to the development of original liver-targeted therapeutic products takes advantage of the employment of biologically active ligands able to bind specific receptors on the cytoplasmatic membranes of liver cells. In this perspective, glycyrrhetinic acid (GA), a pentacyclic triterpenoid present in roots and rhizomes of licorice, has been used as a ligand for targeting the liver due to the expression of GA receptors on the sinusoidal surface of mammalian hepatocytes, so it may be employed to modify drug delivery systems (DDSs) and obtain better liver or hepatocyte drug uptake and efficacy. In the current review, we focus on the most recent and interesting research advances in the development of GA-based hybrid compounds and DDSs developed for potential employment as efficacious therapeutic options for the treatment of hepatic cancer.

show abstract

“…10 The nanoparticle size obtained using this procedure has a broad range (from 50 to 2000 nm 11 ) due to complex thermodynamics and kinetics, which inherently leads to size heterogeneity of self-assembled polyelectrolytes. 12 There has been significant interest in controlling the average size and polydispersity of chitosan nanoparticles 13 as these factors determine their effectiveness and longevity in a biological environment. 14 From the literature, we know that the average size depends on several synthesis parameters including chitosan molecular weight (MW) and degree of deacetylation, chitosan to TPP mass ratio and concentration, pH, ionic strength, temperature, and mixing conditions of the chitosan solution.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of chitosan nanoparticles using the coffee‐ring effect for photodynamic therapy

et al. 2022

View full text Add to dashboard Cite

Background and Objectives: Biocompatible nanoparticles have been increasingly used in a variety of medical applications, including photodynamic therapy. Although the impact of synthesis parameters and purification methods is reported in previous studies, it is still challenging to produce a reliable protocol for the fabrication, purification, and characterization of nanoparticles in the 200-300 nm range that are highly monodisperse for biomedical applications. Study Design/Materials and Methods: We investigated the synthesis of chitosan nanoparticles in the 200-300 nm range by evaluating the chitosan to sodium tripolyphosphate (TPP) mass ratio and acetic acid concentration of the chitosan solution. Chitosan nanoparticles were also crosslinked to rose bengal and incubated with human breast cancer cells (MCF-7) to test photodynamic activity using a green laser (λ = 532 nm, power = 90 mW). Results: We established a simple protocol to fabricate and purify biocompatible nanoparticles with the most frequent size occurring between 200 and 300 nm. This was achieved using a chitosan to TPP mass ratio of 5:1 in 1% v/v acetic acid at a pH of 5.5. The protocol involved the formation of nanoparticle coffee rings that showed the particle shape to be spherical in the first approximation. Photodynamic treatment with rose bengal-nanoparticles killed ~98% of cancer cells. Conclusion: A simple protocol was established to prepare and purify spherical and biocompatible chitosan nanoparticles with a peak size of ~200 nm. These have remarkable antitumor activity when coupled with photodynamic treatment.

show abstract

Design of chitosan-based particle systems: A review of the physicochemical foundations for tailored properties

Cited by 46 publications

References 132 publications

Recovery of Heavy Metal Ions Using Magnetic Glycine-Modified Chitosan—Application to Aqueous Solutions and Tailing Leachate

Recovery of Heavy Metal Ions Using Magnetic Glycine-Modified Chitosan—Application to Aqueous Solutions and Tailing Leachate

Recent Advances in Glycyrrhetinic Acid-Functionalized Biomaterials for Liver Cancer-Targeting Therapy

Fabrication and characterization of chitosan nanoparticles using the coffee‐ring effect for photodynamic therapy

Contact Info

Product

Resources

About