Design of biodegradable, implantable devices towards clinical translation

Li, Chunmei; Guo, Chengchen; Fitzpatrick, Veronica; Ibrahim, Ahmed M.S.; Zwierstra, Myrthe Jasmijn; Hanna, Philip C.; Lechtig, Aron; Nazarian, Ara; Lin, Samuel J.; Kaplan, David L.

doi:10.1038/s41578-019-0150-z

Cited by 530 publications

(554 citation statements)

References 224 publications

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“…While features of biopolymers such as hydrophilicity, biodegradability, biocompatibility, porosity, and non-toxicity make them attractive materials in many biomedical applications; hydrophobicity combined with biocompatibility and non-toxicity could be determinant in some selected applications where hydrophobicity is a key advantage [140][141][142]. On the other hand, the processing of the polymer and the device's design are equally critical for successful tissue engineering applications [143][144][145][146][147].…”

Section: Biodegradable Polymers As Devices For Tissue Engineeringmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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Section: Biodegradable Polymers As Devices For Tissue Engineeringmentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

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“…Continuous efforts have been putting forward to improve the outcomes of implantable devices using biodegradable materials. Biodegradable nanoparticles not only are employed in the nanodrug delivery systems but can also be incorporated in the implantable devices such as orthopedic fixation devices (including fracture-fixation pins and plates, interference screws, suture anchors, craniomaxillofacial fixation devices and tacks for meniscal repair), and biodegradable stents for percutaneous coronary intervention [112,113]. A number of these devices have already been approved and are available in the market [112].…”

Section: Implantable Device With Biodegradable Materialsmentioning

confidence: 99%

“…Biodegradable nanoparticles not only are employed in the nanodrug delivery systems but can also be incorporated in the implantable devices such as orthopedic fixation devices (including fracture-fixation pins and plates, interference screws, suture anchors, craniomaxillofacial fixation devices and tacks for meniscal repair), and biodegradable stents for percutaneous coronary intervention [112,113]. A number of these devices have already been approved and are available in the market [112]. The biodegradable nanoparticles enable the implanted devices to gradually degrade while the host tissues undergo constructive remodeling, eventually replacing the implant [112].…”

Section: Implantable Device With Biodegradable Materialsmentioning

confidence: 99%

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Systemic Review of Biodegradable Nanomaterials in Nanomedicine

2020

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Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized biodegradable nanomaterials have significantly improved the safety profile of nanomedicine. Objective: Our goal is to evaluate different types of biodegradable nanomaterials that have been functionalized for their biomedical applications. Method: In this review, we used PubMed as our literature source and selected recently published studies on biodegradable nanomaterials and their applications in nanomedicine. Results: We found that biodegradable polymers are commonly functionalized for various purposes. Their property of being naturally degraded under biological conditions allows these biodegradable nanomaterials to be used for many biomedical purposes, including bio-imaging, targeted drug delivery, implantation and tissue engineering. The degradability of these nanoparticles can be utilized to control cargo release, by allowing efficient degradation of the nanomaterials at the target site while maintaining nanoparticle integrity at off-target sites. Conclusion: While each biodegradable nanomaterial has its advantages and disadvantages, with careful design and functionalization, biodegradable nanoparticles hold great future in nanomedicine.

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“…In addition to the biomaterial surface topography, "stagedependent" host immune responses can be strongly upregulated by biodegradable implants and their degradation products. As recently reviewed in detail, [166] the host responses to degradable materials are dependent on the class of material and the conditions opposed to the material at the specific implant location. In the case of commonly used synthetic polymers (e.g., poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA) and poly caprolactone (PCL)), small molecule degradation products activate the host response by engaging pathogen-recognition receptors or activating dendritic and T cells, [166,167] while local pH changes activate complement system.…”

Section: Influence Of Materials Chemistry In Immune-instructive Biomatmentioning

confidence: 99%

Combating Implant Infections: Shifting Focus from Bacteria to Host

et al. 2020

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commensal skin bacteria, Staphylococci, and in particular Staphylococcus aureus, have a strong tendency to colonize foreign bodies and cause IAI. [3,4] Important for the underlying pathophysiology, Staphylococci are highly competent at producing biofilms on implant surfaces, which encapsulate the bacterial niche from the outside environment, [5,6] thereby protecting the bacteria from host defense systems and antibiotics. [7] Antibiotics are administered as a routine procedure. [8] However, as a consequence of widespread antibiotics usage, bacteria are exposed to subinhibitory concentrations of antibiotics at a larger scale, driving their development toward antibiotic resistance, [9] as illustrated by the emergence of methicillin-resistant S. aureus (MRSA). [10,11] As an improvement over current clinically applied local antibiotics delivery systems, [12] the recent developments in implant surface engineering approaches allow better antimicrobial functionalities to be incorporated to allow for more tunable and controlled drug release. [13-15] The "race to the surface" model is popular among biomaterials researchers to predict the biomaterials fate, resulting from the competition between eukaryotic cells and bacteria at the material surface. [16] Using this template, implant antibacterial properties are being stemmed from direct contact killing mechanisms due to implant surface modifications [17,18] or firm immobilization of drugs, [19,20] as they both "shield" the implant from bacterial adhesion. The current anti-infective biomaterials strategies being explored can be categorized as: 1) implant functionalization with antibiotics or antibacterial drugs such as host defense peptides (HDPs), inorganic materials (e.g., chitosan and derivatives), and inorganics (e.g., silver, copper, and zinc metal nanoparticles (NPs)), 2) anti-biofilm surface modification (e.g., coating with antifouling polymers or quorum sensor inhibitors), or 3) physical surface changes for direct contact-killing properties (e.g., nanotubes, nanopillars, and metal implantation). [15,21] Emerging as a serious alternative or adjuvant therapy to antibiotics, bacteriophage (phage) therapy uses viruses responsible for the lysis of specific bacterial strains. [22,23] As a natural predator of bacteria, phages employ different killing mechanisms, making multidrug resistant bacteria susceptible for phages. [24] Moreover, phages are highly specific for pathogenic cells, which can eliminate disastrous off-target effects in the host. [25] As a limitation, the use of phage cocktails is needed for therapeutic efficacy, [26] while there is currently is no conclusive data on possible long-term side effects of phage therapy in The widespread use of biomaterials to support or replace body parts is increasingly threatened by the risk of implant-associated infections. In the quest for finding novel anti-infective biomaterials, there generally has been a one-sided focus on biomaterials with direct antibacterial properties, which leads to excessive use of antibacterial ag...

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Design of biodegradable, implantable devices towards clinical translation

Cited by 530 publications

References 224 publications

Recent Advances in Bioplastics: Application and Biodegradation

Recent Advances in Bioplastics: Application and Biodegradation

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Combating Implant Infections: Shifting Focus from Bacteria to Host

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