Design of Biocompatible Multifunctional Hydrogels with Stearyl Methacrylate and Vinylpyrrolidone

Kılıç, Hüsna; Tuncaboylu, Deniz Ceylan; Arğun, Aslıhan; Civelek, Dilek Ozturk

doi:10.1021/acsapm.1c01565

Cited by 6 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This capacity may be used for the anchoring or unfolding of implants to adopt an application-relevant shape in the body [66,67]. SMP hydrogels have also been demonstrated to show a self-healing capacity after mechanical damage, which required the melting of alkyl chain crystals as crosslinks to become flexibly movable hydrophobic units that can aggregate to connect the interfaces of polymer network fragments after mechanical damage [68]. Multifunctional devices with shape switching.…”

Section: Responsiveness To External Stimuli 21 Temperature-responsive...mentioning

confidence: 99%

See 1 more Smart Citation

Opportunities and Challenges of Switchable Materials for Pharmaceutical Use

Tuncaboylu

Wischke

2022

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Switchable polymeric materials, which can respond to triggering signals through changes in their properties, have become a major research focus for parenteral controlled delivery systems. They may enable externally induced drug release or delivery that is adaptive to in vivo stimuli. Despite the promise of new functionalities using switchable materials, several of these concepts may need to face challenges associated with clinical use. Accordingly, this review provides an overview of various types of switchable polymers responsive to different types of stimuli and addresses opportunities and challenges that may arise from their application in biomedicine.

show abstract

Section: Responsiveness To External Stimuli 21 Temperature-responsive...mentioning

confidence: 99%

“…movable hydrophobic units that can aggregate to connect the interfaces of polymer network fragments after mechanical damage [68].…”

Section: Responsiveness To External Stimuli 21 Temperature-responsive...mentioning

confidence: 99%

Opportunities and Challenges of Switchable Materials for Pharmaceutical Use

Tuncaboylu

Wischke

2022

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

Synergetic effect of the crosslinker size and polysaccharide type on the acrylamide networks

Keten,

Gönülkirmaz,

Karacan

et al. 2024

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

The microstructures of hydrogels dominate their properties such as swelling, mechanical, etc., and therefore, their applications. Possessing a homogeneous network lead to uniform swelling and mechanical properties throughout the material. Considering the synergistic effect of crosslinker size and polysaccharide variation, acrylamide hydrogels were synthesized in a single step reaction using tetraethyleneglycol dimethylacrylate (TEGDMA) as a crosslinker in the absence and presence of polysaccharides such as dextran, starch, and sodium alginate. By using the thermal initiator polysaccharides have been used directly without any pre‐functionalization in the single step gelation reaction. All the hydrogel samples were characterized by means of swelling, and mechanical and structural properties. Hydrogels synthesized with TEGDMA as a crosslinker were compared with conventional acrylamide gels prepared using N,N′‐methylenebis(acrylamide) (MBA) and the results emphasized the superior mechanical strength and flexibility of the gels obtained with TEGDMA. Both relatively longer crosslinker and polysaccharide additions have assisted in the formation of a more homogeneous acrylamide network. Polysaccharides which possess plenty of hydroxyl groups have provided a great impact on the swelling properties of the gel samples. Besides the carboxyl groups of alginate backbones have also increased the swelling ratio of the hydrogels additionally. The synergetic effect of the crosslinker and polysaccharide additives on the homogeneity of the acrylamide network and its swelling properties could be suggested for future applications, especially in the area of biomaterials.

show abstract