Design of biocompatible Fe3O4@MPDA mesoporous core-shell nanospheres for drug delivery

Tao, Caihong; Chen, Tiandi; Liu, Hui; Su, Sisi

doi:10.1016/j.micromeso.2019.109823

Cited by 28 publications

(16 citation statements)

References 57 publications

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“…In addition to nanocarriers mentioned above, other special mesoporous materials can be also regarded as significant candidates for drug‐loading and ‐release engineering, such as bioactive glass, [ 16,28 ] calcium silicate, [ 211,212 ] NiS 2 , [ 213 ] black phosphorus, [ 214 ] hydroxyapatite, [ 24,52–54,129,215 ] phosphosilicate, [ 216 ] upconversion nanoparticles, [ 217 ] photonic crystal, [ 218 ] polydopamine, [ 219,220 ] and so on. These mesoporous materials usually have similar characteristics, including tunable pore structure, abundant components, and potential biological activity.…”

Section: Mesoporous Inorganic Biomaterials For Drug Loadingmentioning

confidence: 99%

“…[ 39,40,219 ] Based on its adhesive surface, core–shell Fe 3 O 4 @mPDA can load anticancer drug (DOX) to realize controlled targeted delivery with an external magnetic field based on the strong ferromagnetic of Fe 3 O 4 ( Figure A). [ 220 ] In order to accelerate therapeutic effect, the multifunctional mPDA can incorporate other species, such as Au nanoparticles, and Au–mPDA has efficient protein‐loading capacity and NIR‐triggered release behavior (Figure 9B). [ 219 ] Hence, extensive concerns should be focused on the design and synthesis of mesoporous nanocarriers with versatile structures (e.g., hollow, core–shell, yolk–shell, and network) or components (e.g., silica, carbon, metal, polymer, hybrids) in future research.…”

Section: Mesoporous Inorganic Biomaterials For Drug Loadingmentioning

confidence: 99%

Section: Mesoporous Inorganic Biomaterials For Drug Loadingmentioning

confidence: 99%

“…Alternating magnetic field (AMF) has developed into essential part of clinical medicine, including magnetic resonance imaging and AMF‐stimulated drug delivery, and the application of AMF is combined with other medical techniques, such as high‐intensity focused ultrasound and hyperthermia, which can improve the efficiency of drug release and therapeutic effect. [ 33,220,221,258 ]…”

Section: Stimuli‐responsive Drug‐release Engineeringmentioning

confidence: 99%

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Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering

et al. 2020

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Infectious or immune diseases have caused serious threat to human health due to their complexity and specificity, and emerging drug delivery systems (DDSs) have evolved into the most promising therapeutic strategy for drug‐targeted therapy. Various mesoporous biomaterials are exploited and applied as efficient nanocarriers to loading drugs by virtue of their large surface area, high porosity, and prominent biocompatibility. Nanosized mesoporous nanocarriers show great potential in biomedical research, and it has become the research hotspot in the interdisciplinary field. Herein, recent progress and assembly mechanisms on mesoporous inorganic biomaterials (e.g., silica, carbon, metal oxide) are summarized systematically, and typical functionalization methods (i.e., hybridization, polymerization, and doping) for nanocarriers are also discussed in depth. Particularly, structure–activity relationship and the effect of physicochemical parameters of mesoporous biomaterials, including morphologies (e.g., hollow, core–shell), pore textures (e.g., pore size, pore volume), and surface features (e.g., roughness and hydrophilic/hydrophobic) in DDS application are overviewed and elucidated in detail. As one of the important development directions, advanced stimuli‐responsive DDSs (e.g., pH, temperature, redox, ultrasound, light, magnetic field) are highlighted. Finally, the prospect of mesoporous biomaterials in disease therapeutics is stated, and it will open a new spring for the development of mesoporous nanocarriers.

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Section: Mesoporous Inorganic Biomaterials For Drug Loadingmentioning

confidence: 99%

Section: Mesoporous Inorganic Biomaterials For Drug Loadingmentioning

confidence: 99%

Section: Mesoporous Inorganic Biomaterials For Drug Loadingmentioning

confidence: 99%

Section: Stimuli‐responsive Drug‐release Engineeringmentioning

confidence: 99%

See 2 more Smart Citations

Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering

et al. 2020

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show abstract

“…[22][23][24][25][26] In the drug carrier's actual application, the targeted drug carrier should have good biocompatibility and accurately target the body fluid environment's desired location [27,28].As a magnetic material, Fe 3 O 4 is widely used in human treatment because of its stable quality, superparamagnetic properties, and easy realization. Fe 3 O 4 nanoparticles are widely used as biomaterials and exhibit superparamagnetic properties in magnetic resonance imaging (MRI), targeted hyperthermia, drug delivery, and immobilized proteins [29][30][31][32][33].However, as a magnetically targeting drug carrier, its biocompatibility is poor. A variety of natural and synthetic biodegradable polymers are used for drug delivery [34][35][36].Among various polymers, polyvinyl alcohol (PVA) has received more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research

Wang

Shi

Sun³

et al. 2020

Designed Monomers and Polymers

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Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe 3 O 4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe 3 O 4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe 3 O 4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe 3 O 4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.

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Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

Xie

Tang

Xing

et al. 2021

Adv Healthcare Materials

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The translation of mussel‐inspired wet adhesion to biomedical engineering fields have catalyzed the emergence of polydopamine (PDA)‐based nanomaterials with privileged features and properties of conducting multiple interfacial interactions. Recent concerns and progress on the understanding of PDA's hierarchical structure and progressive assembly are inspiring approaches toward novel nanostructures with property and function advantages over simple nanoparticle architectures. Major breakthroughs in this field demonstrated the essential role of π–π stacking and π‐cation interactions in the rational intervention of PDA self‐assembly. In this review, the recently emerging concepts in the preparation and application of PDA nanomaterials, including 3D mesostructures, low‐dimensional nanostructures, micelle/nanoemulsion based nanoclusters, as well as other multicomponent nanohybrids by the segregation and organization of PDA building blocks on nanoscale interfaces are outlined. The contribution of π‐electron interactions on the interfacial loading/release of π electron‐rich molecules (nucleic acids, drugs, photosensitizers) and the exogenous coupling of optical energy, as well as the impact of wet‐adhesion interactions on the nano‐bio interface interplay, are highlighted by discussing the structure‐property relationships in their featured applications including fluorescent biosensing, gene therapy, drug delivery, phototherapy, combined therapy, etc. The limitations of current explorations, and future research directions are also discussed.

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Design of biocompatible Fe3O4@MPDA mesoporous core-shell nanospheres for drug delivery

Cited by 28 publications

References 57 publications

Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering

Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering

Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research

Intervention of Polydopamine Assembly and Adhesion on Nanoscale Interfaces: State‐of‐the‐Art Designs and Biomedical Applications

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