Design of bioactive peptides derived from CART sequence isolated from the toadfish Thalassophryne nattereri

Conceição, Kátia; Cena, Gabrielle Lupeti de; Silva, Verônica A. da; Neto, Xisto Antonio de Oliveira; Andrade, Vitor Martins de; Tada, Dayane Batista; Richardson, Michael; Andrade, Sofia; Dias, Susana A.; Castanho, Miguel A. R. B.; Lopes-Ferreira, Mônica

doi:10.1007/s13205-020-2151-4

Cited by 5 publications

(3 citation statements)

References 66 publications

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“…Using known sequencing information for specific peptides and manipulation on the molecular level resulted in the creation of novel peptides with improved anti-microbial properties (Conceição et al 2020 ). The designing of novel bioactive peptides was based on the computational algorithm and produced different analogs that were then tested for physiochemical stability and screened for anti-microbial properties.…”

Section: Mnp/maa Biotechnological Applicationsmentioning

confidence: 99%

Recent advances in the discovery of novel marine natural products and mycosporine-like amino acid UV-absorbing compounds

Rosic

2021

Appl Microbiol Biotechnol

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Bioactive compounds from marine environments represent a rich source of bioproducts for potential use in medicine and biotechnology. To discover and identify novel marine natural products (MNPs), evaluating diverse biological activities is critical. Increased sensitivity and specificity of omics technologies, especially next-generation high-throughput sequencing combined with liquid chromatography-mass spectrometry and nuclear magnetic resonance, are speeding up the discovery of novel bioactive compounds. Mycosporine-like amino acids (MAAs) isolated from many marine microorganisms are among highly promising MNPs characterized by ultraviolet radiation (UV) absorbing capacities and are recognized as a potential source of ecologically friendly sunscreens. MAAs absorb damaging UV radiation with maximum absorption in the range of 310–360 nm, including both UVA and UVB ranges. MAAs are also characterized by other biological activities such as anti-oxidant, anti-cancer, and anti-inflammatory activities. The application of modern omics approaches promoted some recent developments in our understanding of MAAs’ functional significance and diversity. This review will summarize the various modern tools that could be applied during the identification and characterization of MNPs, including MAAs, to further their innovative applications. Key points • New omics technologies are speeding up the discovery of novel bio-products • The vast diversity of bioactive capacities of marine natural products described • Marine microorganisms as a source of environmentally friendly sunscreens

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Section: Mnp/maa Biotechnological Applicationsmentioning

confidence: 99%

Recent advances in the discovery of novel marine natural products and mycosporine-like amino acid UV-absorbing compounds

Rosic

2021

Appl Microbiol Biotechnol

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“…E. coli, for example, is mostly harmless, but under abnormal growth it can cause serious diseases in humans, such as gastroenteritis and infections in the urinary tract, bloodstream and central nervous system. In an attempt to minimize the problem of drug resistance, some alternatives have been considered, such as the development of new antibiotics [22] or the development of alternative therapies such as the therapy based on the use of bioactive peptides [23][24][25]; phytochemicals or nanoparticles [26][27][28]. Antimicrobial photodynamic therapy (aPDT) is another example of alternative therapy that has shown encouraging results in experimental and clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Diamond Nanoparticles-Porphyrin mTHPP Conjugate as Photosensitizing Platform: Cytotoxicity and Antibacterial Activity

Hurtado

Cena

et al. 2021

Nanomaterials

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Conjugation of photosensitizers (PS) with nanoparticles has been largely used as a strategy to stabilize PS in the biological medium resulting in photosensitizing nanoparticles of enhanced photoactivity. Herein, (Meso-5, 10, 15, 20-tetrakis (3-hydroxyphenyl) phorphyryn (mTHPP) was conjugated with diamond nanoparticles (ND) by covalent bond. Nanoconjugate ND-mTHPP showed suitable stability in aqueous suspension with 58 nm of hydrodynamic diameter and Zeta potential of −23 mV. The antibacterial activity of ND-mTHPP was evaluated against Escherichia coli for different incubation times (0–24 h). The optimal activity was observed after 2 h of incubation and irradiation (660 nm; 51 J/cm2) performed right after the addition of ND-mTHPP (100 μg/mL) to the bacterial suspension. The inhibitory activity was 56% whereas ampicillin at the same conditions provided only 14% of bacterial growth inhibition. SEM images showed agglomerate of ND-mTHPP adsorbed on the bacterial cell wall, suggesting that the antimicrobial activity of ND-mTHPP was afforded by inducing membrane damage. Cytotoxicity against murine embryonic fibroblast cells (MEF) was also evaluated and ND-mTHPP was shown to be noncytotoxic since viability of cells cultured for 24 h in the presence of the nanoconjugate (100 μg/mL) was 78%. Considering the enhanced antibacterial activity and the absence of cytotoxic effect, it is possible to consider the ND-mTHPP nanoconjugate as promising platform for application in antimicrobial photodynamic therapy (aPDT).

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“…);Conceição et al (2020);Corrêa et al (2011);Cruz et al (2020);Dornelles et al (2018);Fagundes et al (2011);Ferreira et al (2015);Fontenele et al (2017);Galli et al (2019);Games et al (2016); Lima et al (2018); Luz et al (2017); Machado et al (2012); Machado et al (2016); Mandal et al (2014); Meira et al (2012); Migliolo et al (2016); Nascimento et al (2021b); Oliveira et al (2019c); Sanches et al (2021); Santana et al (2020); Santos et al (2021); Silva et al (2019a); Torres-Rêgo et al (2019); Zanutto-Elgui et al (2019); Plácido et al (2020); Oliveira Filho et al (2021) Anticancer Inhibition of cancer cell proliferation Arruda et al (2017); Assis et al (2016); Brand et al (2019); Crusca Jr. et al (2018); Daroit et al (2012); Dematei et al (2021); Figueiredo et al (2015); Fontenele et al (2017); Galli et al (2019); Gomes et al (2020); Lima et al (2015); Lima et al (2020); Magalhães et al (2013); Martins et al (2019); Massaoka et al (2014); Matsuo et al (2011); Mello et al (2015); Mello et al (2020); Montalvo et al (2019); Nascimento et al (2011); Quadros et al (2019); Ramada et al (2017); Silva et al (2012); Silva-Stenico et al (2011); Torres et al (2018); Yekta et al glucose levels (hyperglycemia and hypoglycemia) Baptista et al (2020b); Barati et al (2020); Brandelli et al (2015); Callegaro et al (2018); Henaux et al (2021); Landim et al (2021); Martins-Santos et al (2011); Ohara et al (2020); Rocha et al (2015); Vogel et al (2021) Antigenicity Interaction with previously sensitized T and B lymphocytes Landim et al (2021) Continue...…”

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confidence: 99%

Ten years of research on bioactive peptides in Brazil: a scientometric analysis

SILVA,

BARBOSA,

MARINHO

et al. 2023

Food Sci. Technol (Campinas)

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Peptides are biomolecules composed of amino acids linked through peptide bonds present in proteins. These peptides may have biological activities associated with their secondary structure, especially when released from the original protein sequence. The prospect of these biomolecules is the subject of study and research in various sectors, including the food and pharmaceutical industries. This is due to the possibility of using them as substitutes for traditionally marketed drugs, especially those with restrictive legislation on their use, or losing their effectiveness. A scientometric analysis of studies published from 2011 to 2021 by Brazilian researchers demonstrated the growing interest in basic research involving bioactive peptides from numerous protein sources, including food-based and agro-industrial residues. The antioxidant activity, followed by the antimicrobial potential, has been the most studied property of these biomolecules. Several other activities such as anxiolytic, anti-adipogenic, anticoagulant, anticonvulsant, antisclerotic, and cytoregulatory actions have been reported in a limited number of studies, highlighting the potential application of these biomolecules in the development of new products.

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Design of bioactive peptides derived from CART sequence isolated from the toadfish Thalassophryne nattereri

Cited by 5 publications

References 66 publications

Recent advances in the discovery of novel marine natural products and mycosporine-like amino acid UV-absorbing compounds

Recent advances in the discovery of novel marine natural products and mycosporine-like amino acid UV-absorbing compounds

Diamond Nanoparticles-Porphyrin mTHPP Conjugate as Photosensitizing Platform: Cytotoxicity and Antibacterial Activity

Ten years of research on bioactive peptides in Brazil: a scientometric analysis

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