Design of bifurcation junctions in artificial vascular vessels additively manufactured for skin tissue engineering

Han, Xiaoxiao; Bibb, Richard; Harris, Russell A.

doi:10.1016/j.jvlc.2014.12.005

Cited by 15 publications

(14 citation statements)

References 29 publications

(57 reference statements)

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“…No matter what its thickness, which ranges from 50μm in the eyelids to 1.5 mm on the palms and soles, the epidermis lacks a direct blood supply [11]. In the underlying dermis, it depends on diffusion for the supply of nutrients and elimination of residual waste through the epidermal basement membrane [11], which is a semipermeable thin tissue formed by ECM that separates the epidermis from the dermal connective tissue [12]. Components of the basement membrane include collagen type IV, laminin, nidogen and perlecan [13].…”

Section: General Description Of the Skin Tissuementioning

confidence: 99%

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

Castaño

Pérez‐Amodio

Nieva

et al. 2018

Advanced Drug Delivery Reviews

160

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Skin wound healing aims to repair and restore tissue through a multistage process that involves different cells and signalling molecules that regulate the cellular response and the dynamic remodelling of the extracellular matrix. Nowadays, several therapies that combine biomolecule signals (growth factors and cytokines) and cells are being proposed. However, a lack of reliable evidence of their efficacy, together with associated issues such as high costs, a lack of standardization, no scalable processes, and storage and regulatory issues, are hampering their application. In situ tissue regeneration appears to be a feasible strategy that uses the body's own capacity for regeneration by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the wound site to promote repair and regeneration. The aim is to engineer instructive systems to regulate the spatio-temporal delivery of proper signalling based on the biological mechanisms of the different events that occur in the host microenvironment. This review describes the current state of the different signal cues used in wound healing and skin regeneration, and their combination with biomaterial supports to create instructive microenvironments for wound healing.

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Section: General Description Of the Skin Tissuementioning

confidence: 99%

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

Castaño

Pérez‐Amodio

Nieva

et al. 2018

Advanced Drug Delivery Reviews

160

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“…29 The WSS in blood vessels affects the development of the endothelium and is critical especially in branched vessels where the WSS can be significantly higher than in straight vessels. 108 Han et al 109 developed an algorithm to model the geometry of bifurcating vascular grafts and studied the effect of branching on the WSS and blood flow in engineered vascular grafts. 108 Their study revealed the smooth junctions to be better than the sharp junctions to mix two blood flows.…”

Section: Mechanical Properties Of Self-standing Vascular Graftsmentioning

confidence: 99%

Additive Manufacturing of Vascular Grafts and Vascularized Tissue Constructs

Elomaa

Yang

2017

Tissue Engineering Part B: Reviews

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There is a great need for engineered vascular grafts among patients with cardiovascular diseases who are in need of bypass therapy and lack autologous healthy blood vessels. In addition, because of the severe worldwide shortage of organ donors, there is an increasing need for engineered vascularized tissue constructs as an alternative to organ transplants. Additive manufacturing (AM) offers great advantages and flexibility of fabrication of cell-laden, multimaterial, and anatomically shaped vascular grafts and vascularized tissue constructs. Various inkjet-, extrusion-, and photocrosslinking-based AM techniques have been applied to the fabrication of both self-standing vascular grafts and porous, vascularized tissue constructs. This review discusses the state-of-the-art research on the use of AM for vascular applications and the key criteria for biomaterials in the AM of both acellular and cellular constructs. We envision that new smart printing materials that can adapt to their environment and encourage rapid endothelialization and remodeling will be the key factor in the future for the successful AM of personalized and dynamic vascular tissue applications.

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“…Rounding the apex at each junction can be one of the solutions. The authors developed an algorithm of computational geometry for the construction of vascular branches using a rounded apex[ 18 , 19 ]. CFD simulations were also carried out to test the design and they concluded that rounded junctions in the bifurcation branch result in a more uniform WSS distribution compared to sharp junctions.…”

Section: Design Rules Of Vascular Networkmentioning

confidence: 99%

“…In our previous work[ 18 , 19 ], a set of design rules were developed for designing one single artificial vascular branch made by 3D printing. This paper focuses on further development of design rules for complex artificial vascular networks based on multiscale physiological demands.…”

Section: Introductionmentioning

confidence: 99%

Optimized vascular network by stereolithography for tissue engineered skin

Han¹,

Courseaus²,

Khamassi³

et al. 2024

IJB

Self Cite

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This paper demonstrates the essential and efficient methods to design, and fabricate optimal vascular network for tissue engineering structures based on their physiological conditions. Comprehensive physiological requirements in both micro and macro scales were considered in developing the optimisation design for complex vascular vessels. The optimised design was then manufactured by stereolithography process using materials that are biocompatible, elastic and surface bio-coatable. The materials are self-developed photocurable resin consist of BPA-ethoxylated-diacrylate, lauryl acrylate and isobornylacrylate with Irgacure ® 184, the photoinitiator. The optimised vascular vessel offers many advantages: 1) it provides the maximum nutrient supply; 2) it minimises the recirculation areas and 3) it allows the wall shear stress on the vessel in a healthy range. The stereolithography manufactured vascular vessels were then embedded in the hydrogel seeded with cells. The results of in vitro studies show that the optimised vascular network has the lowest cell death rate compared with a pure hydrogel scaffold and a hydrogel scaffold embedded within a single tube in day seven. Consequently, these design and manufacture routes were shown to be viable for exploring and developing a high range complex and specialised artificial vascular networks.

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Design of bifurcation junctions in artificial vascular vessels additively manufactured for skin tissue engineering

Cited by 15 publications

References 29 publications

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

Instructive microenvironments in skin wound healing: Biomaterials as signal releasing platforms

Additive Manufacturing of Vascular Grafts and Vascularized Tissue Constructs

Optimized vascular network by stereolithography for tissue engineered skin

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