Design of Bifunctional Pyclen-Based Lanthanide Luminescent Bioprobes for Targeted Two-Photon Imaging

Hamon, Nadège; Bridou, Lucile; Roux, Margaux; Maury, Olivier; Tripier, Raphaël; Beyler, Maryline

doi:10.1021/acs.joc.3c00287

Cited by 7 publications

(5 citation statements)

References 73 publications

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“…Not only responding to diverse environmental stimuli by structural modulation based on a molecular platform but also superior NIR emission, stability, and longer lifetimes enable lanthanide-coordinated compounds ideal for fluorescence lifetime imaging (FLIM) [68,69] . Highly stable and luminescent β-fluorinated Yb 3+ complexes, which exhibited strong NIR luminescence (Ф = 23%) and extended decay lifetimes (249 μs), were suitable for both steady-state and time-resolved FLIM within the NIR range [70] . Interestingly, these complexes showed specific luminescent signals, precisely revealing intracellular lifetime distributions (100-200 μs) as FLIM.…”

Section: Biological Imagingmentioning

confidence: 99%

Energy transfer process, luminescence optimizing and various applications of lanthanide complexes

Fan,

Wang,

Huang

et al. 2024

Chem Synth

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Modulating the spectroscopic overlap between the emission bands of donors and the absorption spectra of acceptors by various simulations, it is possible to systematically investigate the emission behaviors of lanthanide complexes under different conditions. To establish the relationships between emission behaviors and various external simulations, it is necessary to study the energy transfer rate and efficiency between the donor and acceptor under different conditions to clarify the luminescent mechanism of the complexes, providing a theoretical basis for high-performance smart materials. This review focuses on the recent progress of luminescence performance of lanthanide complexes, including energy transfer mechanisms, emission color modulation, the strategies for optimizing lanthanide luminescence, and finally, various applications based on luminescence performance of lanthanide complexes and lanthanide metal-organic frameworks.

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Section: Biological Imagingmentioning

confidence: 99%

Energy transfer process, luminescence optimizing and various applications of lanthanide complexes

Fan,

Wang,

Huang

et al. 2024

Chem Synth

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“…They are routinely employed in LEDs, medical X-ray computed tomography imaging, anticounterfeiting pigments, and strong permanent magnets for diverse applications like MRI scanners and magnetic levitation trains . Additionally, their outstanding optical properties, intricate energy diagrams, and extended lifetimes, drive the development of luminescent tags for bioanalysis and microscopy. − …”

Section: Introductionmentioning

confidence: 99%

Yb-to-Eu Cooperative Sensitization Upconversion in a Multifunctional Molecular Nonanuclear Lanthanide Cluster in Solution

Panguluri,

Jourdain,

Chakraborty

et al. 2024

J. Am. Chem. Soc.

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Lanthanide metal clusters excel in combining molecular and material chemistry properties. Here, we report an efficient cooperative sensitization UC phenomenon of a Eu 3+ /Yb 3+ nonanuclear lanthanide cluster in CD 3 OD. The synthesis and characterization of the heteronuclear cluster in the solid state and solution are described together with the UC phenomenon showing Eu 3+ luminescence in the visible region upon 980 nm NIR excitation of Yb 3+ at concentrations as low as 100 nM. Alongside being the Eu/Yb cluster to display UC (with a quantum yield value of 4.88 × 10 −8 upon 1.13 W cm −2 excitation at 980 nm), the cluster exhibits downshifted light emission of Yb 3+ in the NIR region upon 578 nm visible excitation of Eu 3+ , which is ascribed to sensitization pathways for Yb through the 5 D 0 energy levels of Eu 3+ . Additionally, a faint emission is also observed at ca. 500 nm upon 980 nm excitation, originating from the cooperative luminescence of Yb 3+ . The [Eu 8 Yb(BA) 16 (OH) 10 ]Cl cluster (BA = benzoylacetonate) is also a field-induced single-molecular magnet (SMM) under 4K with a modest U eff /k B of 8.48 K, thereby joining the coveted list of Yb-SMMs and emerging as a prototype system for next-generation devices, combining luminescence with single-molecular magnetism in a molecular cluster.

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“…In recent years, macrocyclic pyclen (3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene), featuring a pyridine moiety in its backbone, has garnered significant attention as a promising platform for various applications, including MRI CAs, luminescent complexes, and radiometal chelators. − Albelda et al developed a pyclen-based complex exhibiting pH-responsive behavior, as the number of coordinated water molecules varies at different pH values from 1 to 2, which results in a change of relaxivity . Tircso et al reported a pH-sensitive MRI probe, PC2A-EA, which contains an ethylamine moiety that can respond within the biologically relevant pH range .…”

Section: Introductionmentioning

confidence: 99%

Chiral Pyclen-Based Heptadentate Chelates as Highly Stable MRI Contrast Agents

Jian,

Mo,

et al. 2024

Inorg. Chem.

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In recent years, pyclen-based complexes have attracted a great deal of interest as magnetic resonance imaging (MRI) contrast agents (CAs) and luminescent materials, as well as radiopharmaceuticals. Remarkably, gadopiclenol, a Gd(III) bishydrated complex featuring a pyclen-based heptadentate ligand, received approval as a novel contrast agent for clinical MRI application in 2022. To maximize stability and efficiency, two novel chiral pyclen-based chelators and their complexes were developed in this study. Gd-X-PCTA-2 showed significant enhancements in both thermodynamic and kinetic stabilities compared to those of the achiral parent derivative Gd-PCTA. 1 H NMRD profiles reveal that both chiral gadolinium complexes (Gd-X-PCTA-1 and Gd-X-PCTA-2) have a higher relaxivity than Gd-PCTA, while variabletemperature 17 O NMR studies show that the two inner-sphere water molecules have distinct residence times τ M a and τ M b . Furthermore, in vivo imaging demonstrates that Gd-X-PCTA-2 enhances the signal in the heart and kidneys of the mice, and the chiral Gd complexes exhibit the ability to distinguish between tumors and normal tissues in a 4T1 mouse model more efficiently than that of the clinical agent gadobutrol. Biodistribution studies show that Gd-PCTA and Gd-X-PCTA-2 are primarily cleared by a renal pathway, with 24 h residues of Gd-X-PCTA-2 in the liver and kidney being lower than those of Gd-PCTA.

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Design of Bifunctional Pyclen-Based Lanthanide Luminescent Bioprobes for Targeted Two-Photon Imaging

Cited by 7 publications

References 73 publications

Energy transfer process, luminescence optimizing and various applications of lanthanide complexes

Energy transfer process, luminescence optimizing and various applications of lanthanide complexes

Yb-to-Eu Cooperative Sensitization Upconversion in a Multifunctional Molecular Nonanuclear Lanthanide Cluster in Solution

Chiral Pyclen-Based Heptadentate Chelates as Highly Stable MRI Contrast Agents

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