Design of antiretroviral drug-polymeric nanoparticles laden buccal films for chronic HIV therapy in paediatrics

Sneha, R; Hari, B.N. Vedha; Devi, D. Ramya

doi:10.1016/j.colcom.2018.10.004

Cited by 25 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lamivudine-LAM, a water-soluble drug with two main drawbacks: its half-life is only 2 h and has a deficient bioavailability, especially in paediatric patients (68%) [177]. LAM has been included in NPs based on poly(ε-caprolactone)-PCL [178,179], poly lactic-co-glycolic acid-PLGA [141], chitosan and sodium alginate [180], Eudragit E100 [177]. The physico-chemical characterization of the obtained NPs has shown an adequate size of the NPs and a good stability.…”

Section: Nrtis and Nnrtismentioning

confidence: 99%

“…In vitro drug release tests indicate that NPs can support the drug delivery for 24 h, indicating a less frequent administration [179,180]. Sneba et al [177] have reported a more complex study, where LAM-polymeric non-cytotoxic NPs have been included in films for drug delivery through the buccal mucosa barrier. Four mucoadhesive polymers: polyvinyl alcohol-PVA, polyvinyl pyrrolidone-PVP, sodium carboxymethylcellulose-SCM, hydroxypropyl methylcellulose-HPMC have been used to prepare the films.…”

Section: Nrtis and Nnrtismentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

et al. 2020

View full text Add to dashboard Cite

Viral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact. The increased drug resistance and constant viral replication have been the trigger for important studies regarding the use of nanotechnology in antiviral therapies. Nanomaterials offer unique physico-chemical properties that have linked benefits for drug delivery as ideal tools for viral treatment. Currently, different types of nanomaterials namely nanoparticles, liposomes, nanospheres, nanogels, nanosuspensions and nanoemulsions were studied either in vitro or in vivo for drug delivery of antiviral agents with prospects to be translated in clinical practice. This review highlights the drug delivery nanosystems incorporating the major antiviral classes and their transport across specific barriers at cellular and intracellular level. Important reflections on nanomedicines currently approved or undergoing investigations for the treatment of viral infections are also discussed. Finally, the authors present an overview on the requirements for the design of antiviral nanotherapeutics.

show abstract

Section: Nrtis and Nnrtismentioning

confidence: 99%

Section: Nrtis and Nnrtismentioning

confidence: 99%

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This approach, combined with the conjugation of ART, may potentially be used to target sequestered viral genomes and reach brain reservoirs in a controlled, sustained, and nontoxic manner. ART nanoparticles are envisioned to preserve the innate therapeutic and nontoxic properties of original drugs while increasing bioavailability in comparison with traditional pharmacokinetic properties [ 94 ]. Future directions suggest the use of nanomedicine as a vehicle for drug delivery that can be applied not only to targeting HIV viral reservoirs within the brain, but can be expanded to other targeted neurological therapeutics from treating diseases such as brain tumors, brain infections, brain degeneration, blood flow disruptions, and even autoimmune disorders.…”

Section: Nanomedicine As a Vehicle To Cross The Bbb While Preserving mentioning

confidence: 99%

The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies

Osborne

Peyravian

Nair

et al. 2020

Trends in Neurosciences

104

View full text Add to dashboard Cite

HIV attacks the body’s immune cells, frequently compromises the integrity of the blood–brain barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB further potentiates viral replication within the CNS, which can lead to HIV-associated neuropathology. Antiretroviral therapy (ART) significantly improves HIV patient outcomes and reduces mortality rates. However, there has been limited progress in targeting latent viral reservoirs within the CNS, which may eventually lead to rebound viremia. While ART drugs are shown to be effective in attenuating HIV replication in the periphery, the protection of the brain by the BBB offers an isolated sanctuary to harbor HIV and maintains chronic and persistent replication within the CNS. In this review, we elucidate the pathology of the BBB, its ability to potentiate viral replication, as well as current therapies and insufficiencies in treating HIV-infected individuals.

show abstract

“…Buccal films containing drug-loaded nanoparticles have been investigated before using a wide range of drugs and materials for both the film and nanoparticle carrier [29,[36][37][38][39][40]. The drug payload in these studies, however, were limited to a maximum value of approximately 1 mg of drug per square centimeter of the film.…”

Section: Introductionmentioning

confidence: 99%

High-Payload Buccal Delivery System of Amorphous Curcumin–Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films

Lim

Hadinoto

2021

IJMS

View full text Add to dashboard Cite

Oral delivery of curcumin (CUR) has limited effectiveness due to CUR’s poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubility enhancement afforded by CUR nanoparticles. Buccal film delivery of drug nanoparticles, nevertheless, has been limited to low drug payload. Herein, we evaluated the feasibilities of three mucoadhesive polysaccharides, i.e., hydroxypropyl methylcellulose (HPMC), starch, and hydroxypropyl starch as buccal films of amorphous CUR–chitosan nanoplex at high CUR payload. Both HPMC and starch films could accommodate high CUR payload without adverse effects on the films’ characteristics. Starch films exhibited far superior CUR release profiles at high CUR payload as the faster disintegration time of starch films lowered the precipitation propensity of the highly supersaturated CUR concentration generated by the nanoplex. Compared to unmodified starch, hydroxypropyl starch films exhibited superior CUR release, with sustained release of nearly 100% of the CUR payload in 4 h. Hydroxypropyl starch films also exhibited good payload uniformity, minimal weight/thickness variations, high folding endurance, and good long-term storage stability. The present results established hydroxypropyl starch as the suitable mucoadhesive polysaccharide for high-payload buccal film applications.

show abstract

Design of antiretroviral drug-polymeric nanoparticles laden buccal films for chronic HIV therapy in paediatrics

Cited by 25 publications

References 30 publications

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers

The Paradox of HIV Blood–Brain Barrier Penetrance and Antiretroviral Drug Delivery Deficiencies

High-Payload Buccal Delivery System of Amorphous Curcumin–Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films

Contact Info

Product

Resources

About