Abstract:An immunoencapsulation strategy for pancreatic islets aimed to reduce the risk of rejection in transplanted patients due to the immune response of the host organism is proposed. In this sense, a polyethylene glycol (PEG) hydrogel functionalized with an immunosuppressive antibody (Ab), such as Cytotoxic T-lymphocyte antigen-4 Ig (CTLA4-Ig), would act as both passive and active barrier to the host immune response. To demonstrate the feasibility of this approach, a photopolymerizable-PEG was conjugated to the sel… Show more
“…antibody-bearing PEG shell grown over pancreatic islets, proposed by Cavallo et al [13]. The goal of their study was to develop an immune-encapsulation strategy to reduce the risk of the rejection of transplants in patients due to the immune response of the host organism.…”
Bioencapsulation involves the envelopment of bioactive compounds or cells to host and protect them from chemical/physical degradation and biological attack from hazardous species or undesired immune responses [...]
“…antibody-bearing PEG shell grown over pancreatic islets, proposed by Cavallo et al [13]. The goal of their study was to develop an immune-encapsulation strategy to reduce the risk of the rejection of transplants in patients due to the immune response of the host organism.…”
Bioencapsulation involves the envelopment of bioactive compounds or cells to host and protect them from chemical/physical degradation and biological attack from hazardous species or undesired immune responses [...]
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