Design of Anisotropic Iron-Oxide-Based Nanoparticles for Magnetic Hyperthermia

Cotin, Geoffrey; Perton, Francis; Blanco-Andujar, Cristina; Pichon, Benoît P.; Mertz, Damien

doi:10.1016/b978-0-12-813928-8.00002-8

Cited by 25 publications

(34 citation statements)

References 110 publications

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“…The heating power of magnetic nanoparticles strongly depends on extrinsic and intrinsic properties, namely the external magnetic field amplitude, the saturation magnetization and the anisotropy energy, which in turn, depends on shape of nanoparticles, so a suitable design of these nanoparticles is an important step for enhanced hyperthermia efficiency [155]. The increase of heating efficiency allows the use of a lower dose of nanoparticles, preventing this way undesirable accumulation and cytotoxicity.…”

Section: Magnetic Hyperthermia Therapymentioning

confidence: 99%

Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications

Andrade

Veloso

Castanheira

2020

IJMS

121

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Research on iron oxide-based magnetic nanoparticles and their clinical use has been, so far, mainly focused on the spherical shape. However, efforts have been made to develop synthetic routes that produce different anisotropic shapes not only in magnetite nanoparticles, but also in other ferrites, as their magnetic behavior and biological activity can be improved by controlling the shape. Ferrite nanoparticles show several properties that arise from finite-size and surface effects, like high magnetization and superparamagnetism, which make them interesting for use in nanomedicine. Herein, we show recent developments on the synthesis of anisotropic ferrite nanoparticles and the importance of shape-dependent properties for biomedical applications, such as magnetic drug delivery, magnetic hyperthermia and magnetic resonance imaging. A brief discussion on toxicity of iron oxide nanoparticles is also included.

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Section: Magnetic Hyperthermia Therapymentioning

confidence: 99%

Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications

Andrade

Veloso

Castanheira

2020

IJMS

121

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“…As a consequence, the net magnetic moment of this structure may be calculated as the difference between the moment in (B) and (A) sites (µ oct − µ tet ), and, in the case of magnetite, this yields 4µ B . The substitution of Fe 2+ ions with Mn 2+ ions (with the electronic configuration 3d 5 ) increases the overall magnetic moment from 4µ B to 5µ B [13,14,15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Hyperthermia, Cytotoxicity, and Cellular Uptake Properties of Manganese and Zinc Ferrite Magnetic Nanoparticles Synthesized by a Polyol-Mediated Process

et al. 2019

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Manganese and zinc ferrite magnetic nanoparticles (MNPs) were successfully synthesized using the polyol method in ethylene glycol and were found to have high saturation magnetization values (90–95 emu/g at 4 K) when formed by ~30-nm crystallites assembled in an ~80-nm multicore structure. Hyperthermia data revealed a sigmoidal dependence of the specific absorption rate (SAR) on the alternating magnetic field (AMF) amplitude, with remarkable saturation SAR values in water of ~1200 W/gFe+Mn and ~800 W/gFe+Zn for the Mn and Zn ferrites, respectively. The immobilization of the MNPs in a solid matrix reduced the maximum SAR values by ~300 W/gFe+Mn, Zn for both ferrites. The alignment of the MNPs in a uniform static magnetic field, before their immobilization in a solid matrix, significantly increased their heating performance. Toxicity assays performed in four cell lines revealed a lower toxicity for the Mn ferrites, while in the case of the Zn ferrites, only ~50% of cells were viable upon their incubation for 24 h with 0.2 mg/mL of MNPs. Cellular uptake experiments revealed that both MNPs entered the cells in a time-dependent manner, as they were found initially in endosomes and later in the cytosol. All of the studied cell lines were more sensitive to the ZnFe2O4 MNPs.

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“…Presently, researchers are putting more emphasis on enhancing the SAR value through the bi-magnetic CS NPs with two different magnetic phases. This displays an exchange bias (EB) coupling phenomenon between the core and shell materials which results in tuning several magnetic properties of the NPs 11 – 14 . EB effect for a particular system consisting of AFM and FiM/FM materials arises when uncompensated AFM spins are usually pinned up with the spins of FiM phase at the magnetically interface surface,which in turn leads to hysteresis loop shift and amplification of coercivity 15 .…”

Section: Introductionmentioning

confidence: 99%

A comparative investigation of normal and inverted exchange bias effect for magnetic fluid hyperthermia applications

Tsopoe

Borgohain

Fopase

et al. 2020

Sci Rep

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Exchange bias (EB) of magnetic nanoparticles (MNPs) in the nanoscale regime has been extensively studied by researchers, which have opened up a novel approach in tuning the magnetic anisotropy properties of magnetic nanoparticles (MNPs) in prospective application of biomedical research such as magnetic hyperthermia. In this work, we report a comparative study on the effect of magnetic EB of normal and inverted core@shell (CS) nanostructures and its influence on the heating efficiency by synthesizing Antiferromagnetic (AFM) NiO (N) and Ferrimagnetic (FiM) Fe3O4 (F). The formation of CS structures for both systems is clearly authenticated by XRD and HRTEM analyses. The magnetic properties were extensively studied by Vibrating Sample Magnetometer (VSM). We reported that the inverted CS NiO@Fe3O4 (NF) MNPs have shown a greater EB owing to higher uncompensated spins at the interface of the AFM, in comparison to the normal CS Fe3O4@NiO (FN) MNPs. Both the CS systems have shown higher SAR values in comparison to the single-phased F owing to the EB coupling at the interface. However, the higher surface anisotropy of F shell with more EB field for NF enhanced the SAR value as compared to FN system. The EB coupling is hindered at higher concentrations of NF MNPs because of the enhanced dipolar interactions (agglomeration of nanoparticles). Both the CS systems reach to the hyperthermia temperature within 10 min. The cyto-compatibility analysis resulted in the excellent cell viability (> 75%) for 3 days in the presence of the synthesized NPs upto 1 mg/ml. These observations endorsed the suitability of CS nanoassemblies for magnetic fluid hyperthermia applications.

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Design of Anisotropic Iron-Oxide-Based Nanoparticles for Magnetic Hyperthermia

Cited by 25 publications

References 110 publications

Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications

Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications

Hyperthermia, Cytotoxicity, and Cellular Uptake Properties of Manganese and Zinc Ferrite Magnetic Nanoparticles Synthesized by a Polyol-Mediated Process

A comparative investigation of normal and inverted exchange bias effect for magnetic fluid hyperthermia applications

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