Design of an elastic porous injectable biomaterial for tissue regeneration and volume retention

Béduer, Amélie; Genta, Martina; Kunz, Nicolas; Verheyen, Connor A.; Martins, Mariana Martins e; Brefie-Guth, Joé; Braschler, Thomas

doi:10.1016/j.actbio.2022.01.050

Cited by 11 publications

(10 citation statements)

References 63 publications

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“…In contrast to this novel finding, previous injectable fillers have not maintained augmentation beyond material degradation 13,26,27 . Additionally, biomaterial scaffolds designed to promote tissue bulking have done so by creating intentional collagen-1 deposition and fibrosis 10,11,26 .…”

Section: Characterization Of Tissue De Novo Formation In Map-treated ...contrasting

confidence: 68%

“…Tissue bulking is desired in many clinical applications where a deficit of patient tissue inhibits normal function, including glottic insufficiency, the specific focus of this study 13,33 . The ideal biomaterial approach would be a resorbable scaffold capable of promoting permanent de novo tissue formation that extends beyond the material lifetime.…”

Section: Discussionmentioning

confidence: 99%

“…Even with these fibrotic approaches, once the FBR subsides patients often still require follow-up surgeries after 2 years 3 . The ideal injectable would be able to provide augmentation permanently by induction of a non-FBR dependent local tissue formation to maintain volume 13 , while retaining the ability to be injected with standard clinical apparatus 5 .…”

Section: Introductionmentioning

confidence: 99%

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De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation

et al. 2023

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Biomaterial-enabled de novo formation of non-fibrotic tissue in situ would provide an important tool to physicians. One example application, glottic insufficiency, is a debilitating laryngeal disorder wherein vocal folds do not fully close, resulting in difficulty speaking and swallowing. Preferred management of glottic insufficiency includes bulking of vocal folds via injectable fillers, however, the current options have associated drawbacks including inflammation, accelerated resorption, and foreign body response. We developed a novel iteration of microporous annealed particle (MAP) scaffold designed to provide persistent augmentation. Following a 14-month study of vocal fold augmentation using a rabbit vocal paralysis model, most MAP scaffolds were replaced with tissue de novo that matched the mixture of fibrotic and non-fibrotic collagens of the contralateral vocal tissue. Further, persistent tissue augmentation in MAP-treated rabbits was observed via MRI and via superior vocal function at 14 months relative to the clinical standard.

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Section: Characterization Of Tissue De Novo Formation In Map-treated ...contrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation

et al. 2023

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“…Thus, not only clinicians’ but especially patients’ preference for fewer invasive and expensive procedures has undoubtedly promoted their use [ 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. An injectable formulation for soft tissues reconstruction currently relies on two main approaches, involving autologous tissue displacement (e.g., lipofilling, platelet-rich plasma) or biomaterials-based filling [ 5 ]. Both approaches have some advantages and drawbacks.…”

Section: Introductionmentioning

confidence: 99%

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

Salvatore¹,

Natali

Brunetti³

et al. 2023

Polymers

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Soft tissues diseases significantly affect patients quality of life and usually require targeted, costly and sometimes constant interventions. With the average lifetime increase, a proportional increase of age-related soft tissues diseases has been witnessed. Due to this, the last two decades have seen a tremendous demand for minimally invasive one-step resolutive procedures. Intensive scientific and industrial research has led to the recognition of injectable formulations as a new advantageous approach in the management of complex diseases that are challenging to treat with conventional strategies. Among them, collagen-based products are revealed to be one of the most promising among bioactive biomaterials-based formulations. Collagen is the most abundant structural protein of vertebrate connective tissues and, because of its structural and non-structural role, is one of the most widely used multifunctional biomaterials in the health-related sectors, including medical care and cosmetics. Indeed, collagen-based formulations are historically considered as the “gold standard” and from 1981 have been paving the way for the development of a new generation of fillers. A huge number of collagen-based injectable products have been approved worldwide for clinical use and have routinely been introduced in many clinical settings for both aesthetic and regenerative surgery. In this context, this review article aims to be an update on the clinical outcomes of approved collagen-based injectables for both aesthetic and regenerative medicine of the last 20 years with an in-depth focus on their safety and effectiveness for the treatment of diseases of the integumental, gastrointestinal, musculoskeletal, and urogenital apparatus.

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“…When the VF is paralyzed or the vibration is weakened, the ECM in the lamina propria (LP) may develop disuse atrophy, i.e., degradation of the innate ECM of the VFs. Hence, in addition to catering for the fundamental requirements such as injectability, biocompatibility and volume stability, the desired material for injection laryngoplasty should also be capable to enhance the synthesis of ECM in the VFs, which is a major hurdle clinically [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

A self-fused hydrogel for the treatment of glottic insufficiency through outstanding durability, extracellular matrix-inducing bioactivity and function preservation

Zou

et al. 2023

Bioactive Materials

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Design of an elastic porous injectable biomaterial for tissue regeneration and volume retention

Cited by 11 publications

References 63 publications

De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation

De novo tissue formation using custom microporous annealed particle hydrogel provides long-term vocal fold augmentation

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

A self-fused hydrogel for the treatment of glottic insufficiency through outstanding durability, extracellular matrix-inducing bioactivity and function preservation

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