Design of an aryne-platform for the synthesis of non-racemic heterocyclic allocolchicinoids

Gracheva, Yu. A.; Schmalz, Hans‐Günther; Svirshchevskaya, E. V.; Shchegravina, Ekaterina S.; Fedorov, Alexey Yu.

doi:10.1039/d3ob00827d

Org. Biomol. Chem.

2023

DOI: 10.1039/d3ob00827d

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Design of an aryne-platform for the synthesis of non-racemic heterocyclic allocolchicinoids

Yu. A. Gracheva

Hans‐Günther Schmalz

E. V. Svirshchevskaya

et al.

Abstract: A four-step semisynthetic approach towards a highly versatile allocolchicine-related chiral aryne intermediate starting from naturally occurring colchicine was developed, and some of its synthetic transformations were studied. The in situ...

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The chemistry of heterocycles in the 21st century

Charushin,

Verbitskiy,

Chupakhin

et al. 2024

RUSS CHEM REV

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The chemistry of heterocyclic compounds has traditionally been and remains a bright area of chemical science in Russia. This is due to the fact that many heterocycles find the widest application. These compounds are the key structural fragments of most drugs, plant protection agents. Many natural compounds are also derivatives of heterocycles. At present, more than half of the hundreds of millions of known chemical compounds are heterocycles. This collective review is devoted to the achievements of Russian chemists in this field over the last 15–20 years. The review presents the achievements of leading heterocyclists representing both RAS institutes and university science. It is worth noting the wide scope of the review, both in terms of the geography of author teams, covering the whole of our large country, and in terms of the diversity of research areas. Practically all major types of heterocycles are represented in the review. The special attention is focused on the practical applications of heterocycles in the design of new drugs and biologically active compounds, high-energy molecules, materials for organic electronics and photovoltaics, new ligands for coordination chemistry, and many other rapidly developing areas. These practical advances would not be possible without the development of new fundamental transformations in heterocyclic chemistry.<br> Bibliography — 2237 references.

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The chemistry of heterocycles in the 21st century

Charushin,

Verbitskiy,

Chupakhin

et al. 2024

RUSS CHEM REV

View full text Add to dashboard Cite

show abstract

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Design of an aryne-platform for the synthesis of non-racemic heterocyclic allocolchicinoids

Abstract: A four-step semisynthetic approach towards a highly versatile allocolchicine-related chiral aryne intermediate starting from naturally occurring colchicine was developed, and some of its synthetic transformations were studied. The in situ...

Cited by 1 publication

References 27 publications

The chemistry of heterocycles in the 21st century

The chemistry of heterocycles in the 21st century

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