Design of an alternate antibody fragment format that can be produced in the cytoplasm of Escherichia coli
Aatir A. Tungekar,
Lloyd W. Ruddock
Abstract:With increased accessibility and tissue penetration, smaller antibody formats such as antibody fragments (Fab) and single chain variable fragments (scFv) show potential as effective and low-cost choices to full-length antibodies. These formats derived from the modular architecture of antibodies could prove to be game changers for certain therapeutic and diagnostic applications. Microbial hosts have shown tremendous promise as production hosts for antibody fragment formats. However, low target protein yields co… Show more
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