Design of amino acid-based self-assembled nano-drugs for therapeutic applications

Vong, Long Binh; Trinh, Nhu‐Thuy; Nagasaki, Yukio

doi:10.1016/j.jconrel.2020.06.009

Cited by 21 publications

(10 citation statements)

References 84 publications

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“…This consecutive double enzyme-responsive NO-releasing system, with a polypeptide self-assembling design, prevents the leaking of active components from nanocarrier during blood circulation. Currently, we are focusing on the construction of the concept “enzyme responsive self-assembled macromolecular drugs”, viz., the active components are incorporated as a component of the self-assembling polymer via covalent linkage to prevent the leakage of the drugs during blood circulation and to vary the biodistribution of the drugs, while it collapses at the target site due to highly expressed enzymes at the site [ 62 , 63 , 64 ]. Hubbell et al also reported self-assembling block copolymer micelles containing an NO donor covalently conjugated with the hydrophobic segment; the NO-releasing rate based on the hydrolysis of N -diazeniumdiolate group significantly increased after the disintegration of the micelle [ 65 ].…”

Section: Nanoparticle Systems For Controlled Release Of No Moleculmentioning

confidence: 99%

Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges

Vong

Nagasaki

2020

Antioxidants

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Nitric oxide (NO) plays important roles in various physiological and pathological functions and processes in the human body. Therapeutic application of NO molecules has been investigated in various diseases, including cardiovascular disease, cancer, and infections. However, the extremely short half-life of NO, which limits its clinical use considerably, along with non-specific distribution, has resulted in a low therapeutic index and undesired adverse effects. To overcome the drawbacks of using this gaseous signaling molecule, researchers in the last several decades have focused on innovative medical technologies, specifically nanoparticle-based drug delivery systems (DDSs), because these systems alter the biodistribution of the therapeutic agent through controlled release at the target tissues, resulting in a significant therapeutic drug effect. Thus, the application of nano-systems for NO delivery in the field of biomedicine, particularly in the development of new drugs for cancer treatment, has been increasing worldwide. In this review, we discuss NO delivery nanoparticle systems, with the aim of improving drug delivery development for conventional chemotherapies and controlling multidrug resistance in cancer treatments.

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Section: Nanoparticle Systems For Controlled Release Of No Moleculmentioning

confidence: 99%

Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges

Vong

Nagasaki

2020

Antioxidants

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“…AAs are traditionally classified as nutritionally essential or unessential for humans [4]. It has been reported that AAs were used as a supplementary therapy to treat many disorders [5,6]. Because of their low molecular weight and inefficient pharmacokinetics, they are not very effective in the clinic, which is a practical barrier that needs to be addressed [6].…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that AAs were used as a supplementary therapy to treat many disorders [5,6]. Because of their low molecular weight and inefficient pharmacokinetics, they are not very effective in the clinic, which is a practical barrier that needs to be addressed [6]. Several artificial peptides and proteins consisting of essential AAs have been synthesized and successfully tested for biomedical applications [3].…”

Section: Introductionmentioning

confidence: 99%

“…Multiple biophysical methods can further characterize the stable form of these artificial nanoarchitectures [39]. Compared to free AAs, self-assembled nanostructure complexes composed of AAs have enhanced pharmacokinetic profiles and have shown increased accumulation in specific target sites [6]. Peptide and protein nanotechnology have demonstrated outstanding potential for the mimicry of living matter constituents and helped achieve novel materials by combining proteins/peptides with nonbiological components [40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

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Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Laraib

Arshad

et al. 2021

Nanomaterials

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Over various scientific fields in biochemistry, amino acids have been highlighted in research works. Protein, peptide- and amino acid-based drug delivery systems have proficiently transformed nanotechnology via immense flexibility in their features for attaching various drug molecules and biodegradable polymers. In this regard, novel nanostructures including carbon nanotubes, electrospun carbon nanofibers, gold nanoislands, and metal-based nanoparticles have been introduced as nanosensors for accurate detection of these organic compounds. These nanostructures can bind the biological receptor to the sensor surface and increase the surface area of the working electrode, significantly enhancing the biosensor performance. Interestingly, protein-based nanocarriers have also emerged as useful drug and gene delivery platforms. This is important since, despite recent advancements, there are still biological barriers and other obstacles limiting gene and drug delivery efficacy. Currently available strategies for gene therapy are not cost-effective, and they do not deliver the genetic cargo effectively to target sites. With rapid advancements in nanotechnology, novel gene delivery systems are introduced as nonviral vectors such as protein, peptide, and amino acid-based nanostructures. These nano-based delivery platforms can be tailored into functional transformation using proteins and peptides ligands based nanocarriers, usually overexpressed in the specified diseases. The purpose of this review is to shed light on traditional and nanotechnology-based methods to detect amino acids, peptides, and proteins. Furthermore, new insights into the potential of amino protein-based nanoassemblies for targeted drug delivery or gene transfer are presented.

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“…Design of novel nano/macro architecture with the help of self-assembly is a fast growing fied of research due to wide range of applications. Self-assembled architectures based on the amino acids are of particular interest owing to their applications in different fields which include biomedical application, [1][2][3] sensing, 4 tracking, 5 fabrication 6 etc purpose increase due to its biocompatibility, 7,8 and stability. 9 Amino acid based self-assembled structure formed various types of morphology at supramolecular level due to its amphiphilic character.…”

Section: Introductionmentioning

confidence: 99%

Self-assembled Structures Formed by Fmoc modified aliphatic amino acids

Gour

Koshti

Naskar

et al. 2021

Preprint

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We report the self-assembled structures formed by Fmoc modified aliphatic uncharged single amino acids. The self-assembling properties of (((9H-fluoren-9-yl)methoxy)carbonyl)-L-alanine (Fmoc-Ala-OH), (((9H-fluoren-9-yl)methoxy)carbonyl)-L-leucine (Fmoc-Leu-OH), (((9H-fluoren-9-yl)methoxy)carbonyl)-L-isoleucine (Fmoc-Ile-OH), and (((9H-fluoren-9-yl)methoxy)carbonyl)-L-valine (Fmoc-Val-OH) were studied under varying conditions such as concentration and temperature. Fmoc-Ala-OH shows flower-like self-assembled structure at both low and high concentration under room temperature as well as on heating at 70ºC. We also studied self-assembly of the modified branched chain amino acids (BCAA) i.e. Fmoc-Leu-OH, Fmoc-Ile-OH, and Fmoc-Val-OH. Fmoc-Leu-OH forms flower-like morphology at both low and high concentration under room temperature which changes to small tube-like structure on heating. Fmoc-Ile-OH on the other hand shows fibres-like self-assembly at lower and higher concentration at room temperature. While, on heating at lower concentration they formed a tube like self-assembled structure and at higher concentration they formed a fibres-like morphology. In the case of Fmoc-Val-OH they form a flower-like morphology at lower concentration at room temperature and at higher concentration they formed fibres-like assembly at room temperature. On the other hand, on heating Fmoc-Val-OH shows a fibres-like assembly at lower and higher concentration. Once the self-assembled structure of all Fmoc single amino acid characterized through the optical microscopy then our future aims to characterized those self-assembled structure through sophisticated microscopy and spectroscopy techniques and understand the mechanisms of self-assembled structure. Hence, the modified amino acids may pave the way for the design of novel self-assembled architectures which can be controllable manipulated to impart desired function..

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Design of amino acid-based self-assembled nano-drugs for therapeutic applications

Cited by 21 publications

References 84 publications

Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges

Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Self-assembled Structures Formed by Fmoc modified aliphatic amino acids

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