Design of adhesive conducting PEDOT-MeOH:PSS/PDA neural interface via electropolymerization for ultrasmall implantable neural microelectrodes

Tian, Fajuan; Yu, Jiawen; Wang, Wen; Zhao, Dianbo; Zhao, Qi; Wang, Fucheng; Yang, Hanjun; Wu, Zhixin; Xu, Jingkun; Lu, Baoyang

doi:10.1016/j.jcis.2023.01.146

Cited by 14 publications

(10 citation statements)

References 39 publications

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“…Reproduced with permission. [ 227 ] Copyright 2023, Elsevier. F) i) Schematic strong adhesion of wet conducting polymers on bioelectronic devices with planar microelectrodes, ii) SEM images of PEDOT:PSS electrodeposited on an amine‐functionalized Pt microwire with PU adhesive layer before and after ultrasonication for 30 min in PBS, images of a solvent‐casted wet PEDOT:PSS on an ITO‐glass substrate without (ii) and with (iii) the PU adhesive layer before and after ultrasonication, and iv) the corresponding CSC variation after different CV cycles.…”

Section: Strategies For Improving Durability Of Neural Interfacesmentioning

confidence: 99%

“…Recently, Tian et al. [ 227 ] designed an adhesive conducting PEDOT‐MeOH:PSS/PDA neural interface via a simple two‐step electropolymerization for ultrasmall implantable neural electrodes (Figure 11E). PDA was employed as an adhesive layer, followed by electropolymerization of hydroxymethylated EDOT (EDOT‐MeOH) with PSS in order to form interpenetrating networks.…”

Section: Strategies For Improving Durability Of Neural Interfacesmentioning

confidence: 99%

“…Zeng et al also employed PDA as the adhesive layer to improve the durability of PtNW-coated neural electrode, it still exhibited desirable function after >7000 bending and twisting tests. [88c,101] Recently, Tian et al [227] designed an adhesive conducting PEDOT-MeOH:PSS/PDA neural interface via a simple two-step electropolymerization for ultrasmall implantable neural electrodes (Figure 11E). PDA was employed as an adhesive layer, followed by electropolymerization of hydroxymethylated EDOT (EDOT-MeOH) with PSS in order to form interpenetrating networks.…”

Section: Improve Adhesionmentioning

confidence: 99%

See 2 more Smart Citations

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Zeng

Huang

2023

Adv Funct Materials

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The desirable implantable neural interfaces can accurately record bioelectrical signals from neurons and regulate neural activities with high spatial/time resolution, facilitating the understanding of neuronal functions and dynamics. However, the electrochemical performance (impedance, charge storage/injection capacity) is limited with the miniaturization and integration of neural electrodes. The “crosstalk” caused by the uneven distribution of elctric field leads to lower electrical stimulation/recording efficiency. The mismatch between stiff electrodes and soft tissues exacerbates the inflammatory responses, thus weakening the transmission of signals. Though remarkable breakthroughs have been made through the incorporation of optimizing electrode design and functionalized nanomaterials, the chronic stability, and long‐term activity in vivo of the neural electrodes still need further development. In this review, the neural interface challenges mainly on electrochemistry and biology are discussed, followed by summarizing typical electrode optimization technologies and exploring recent advances in the application of nanomaterials, based on traditional metallic materials, emerging 2D materials, conducting polymer hydrogels, etc., for enhancing neural interfaces. The strategies for improving the durability including enhanced adhesion and minimized inflammatory response, are also summarized. The promising directions are finally presented to provide enlightenment for high‐performance neural interfaces in future, which will promote profound progress in neuroscience research.

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Section: Strategies For Improving Durability Of Neural Interfacesmentioning

confidence: 99%

Section: Strategies For Improving Durability Of Neural Interfacesmentioning

confidence: 99%

Section: Improve Adhesionmentioning

confidence: 99%

See 1 more Smart Citation

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Zeng

Huang

2023

Adv Funct Materials

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“…The reliable and seamless integration of human tissues with bioelectronic devices has been proven promising for diverse applications ranging from bioelectronic applications such as health monitoring and clinical diagnosis to related domains like artificial intelligence and soft robotics, etc. − The search of advanced bioelectronic interfacial materials is critical to perfectly realize seamless integration between human body and bioelectronic devices. Most recently, conducting polymer hydrogels, especially poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)-based hydrogels, have become ideal bioelectronic interfacial materials owing to their mixed electronic and ionic conductivity, tissue-like mechanical properties, and superior biocompatibility. − The last 3 years have witnessed tremendous strides of PEDOT:PSS-based hydrogels toward bioelectronics, including a fundamental understanding of PEDOT:PSS-based hydrogel design and synthesis, , advanced fabrication and manufacturing technologies, , as well as expanded bioelectronic devices and applications like neural recording and stimulation. − …”

Section: Introductionmentioning

confidence: 99%

Design of Highly Conductive, Intrinsically Stretchable, and 3D Printable PEDOT:PSS Hydrogels via PSS-Chain Engineering for Bioelectronics

Tian

Wang

et al. 2023

Chem. Mater.

Self Cite

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Poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)-based hydrogels have emerged as ideal interfacing materials for bioelectronics because of their intriguing electrical, mechanical, and biological properties. However, the development of high-performance PEDOT:PSS-based hydrogels simultaneously achieving high conductivity, robust mechanical properties, and accessibility for advanced manufacturing technologies remains a critical challenge for further advancing such materials toward practical applications. Herein, we develop a highly conductive, intrinsically soft, tough yet stretchable PEDOT:PSS-based hydrogel via a simple PSS-chain engineering strategy of introducing thermally cross-linkable N-(hydroxymethyl)acrylamide segments. The resultant PEDOT:PSS hydrogel exhibits high electrical conductivity (1850 S m–1), high stretchability (>50%), low Young’s modulus (4 MPa), and superior toughness (400 kJ m–3), satisfying multiple property requirements for practical bioelectronic applications. Based on this material, we further develop a novel PEDOT:PSS ink with superior 3D printability for direct ink writing 3D printing, enabling us to facilely fabricate bioelectronic devices like soft skin electrodes comparable to commercial products via multi-material 3D printing.

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“…As electrochemical biosensor properties depend on the overall sensing surface, an enlarged electrode area enabling the transfer of ions and electrons is desirable. A large active surface area can be achieved, for instance, by roughening the electrode, by surface patterning, or by generating three-dimensional structures on the electrode that provide architectures with dimensions from a few hundred nanometers to micrometers [ 12 , 13 , 14 ]. At the same time, an enlarged surface area in combination with functional groups provides excellent binding capabilities for biomolecules [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Study on the Interaction of Plasma-Polymerized Hydrogel Coatings with Aqueous Solutions of Different pH

Levien

Nasri

Weltmann

et al. 2023

Gels

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Amphiphilic hydrogels from mixtures of 2-hydroxyethyl methacrylate and 2-(diethylamino)ethyl methacrylate p(HEMA-co-DEAEMA) with specific pH sensitivity and hydrophilic/hydrophobic structures were designed and polymerized via plasma polymerization. The behavior of plasma-polymerized (pp) hydrogels containing different ratios of pH-sensitive DEAEMA segments was investigated concerning possible applications in bioanalytics. In this regard, the morphological changes, permeability, and stability of the hydrogels immersed in solutions of different pHs were studied. The physico-chemical properties of the pp hydrogel coatings were analyzed using X-ray photoelectron spectroscopy, surface free energy measurements, and atomic force microscopy. Wettability measurements showed an increased hydrophilicity of the pp hydrogels when stored in acidic buffers and a slightly hydrophobic behavior after immersion in alkaline solutions, indicating a pH-dependent behavior. Furthermore, the pp (p(HEMA-co-DEAEMA) (ppHD) hydrogels were deposited on gold electrodes and studied electrochemically to investigate the pH sensitivity of the hydrogels. The hydrogel coatings with a higher ratio of DEAEMA segments showed excellent pH responsiveness at the studied pHs (pH 4, 7, and 10), demonstrating the importance of the DEAEMA ratio in the functionality of pp hydrogel films. Due to their stability and pH-responsive properties, pp (p(HEMA-co-DEAEMA) hydrogels are conceivable candidates for functional and immobilization layers for biosensors.

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Design of adhesive conducting PEDOT-MeOH:PSS/PDA neural interface via electropolymerization for ultrasmall implantable neural microelectrodes

Cited by 14 publications

References 39 publications

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Challenges and Opportunities of Implantable Neural Interfaces: From Material, Electrochemical and Biological Perspectives

Design of Highly Conductive, Intrinsically Stretchable, and 3D Printable PEDOT:PSS Hydrogels via PSS-Chain Engineering for Bioelectronics

Study on the Interaction of Plasma-Polymerized Hydrogel Coatings with Aqueous Solutions of Different pH

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