Design of a very high-resolution small animal PET scanner using a silicon scatter detector insert

Park, Sang June; Rogers, W.L.; Clinthorne, N.H.

doi:10.1088/0031-9155/52/15/019

Cited by 35 publications

(28 citation statements)

References 34 publications

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“…While timing and foundries limit unit thickness to 0.5-1 mm range, stacks of few sensors could achieve required efficiency at moderate technological expense. The number of layers in the stack would be optimized for a single Compton interaction [5] to prevent uncertainty in the determination of the interaction position. The optimized stack would achieve efficiency in the 10-15% range.…”

Section: Discussionmentioning

confidence: 99%

“…Such configuration would enhance photon sensitivity by increasing the system's geometric detection efficiency [4], and improve its spatial resolution. A number of multi-resolution PET concepts have been investigated by several groups, utilizing either semiconductor materials such as silicon [5][6][7][8][9] and cadmium zinc telluride (CdZnTe) [10,11] or scintillators such as cerium-doped lutetium (-yttrium) oxyorthosilicate (L(Y)SO) [12][13][14][15][16], usually read out by silicon photomultipliers (SiPMs).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a high resolution silicon PET insert module

Grkovski

Brzezinski²,

Cindro

et al. 2015

Nuclear Instruments and Methods in Physics Research Section A:

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a b s t r a c tConventional PET systems can be augmented with additional detectors placed in close proximity of the region of interest. We developed a high resolution PET insert module to evaluate the added benefit of such a combination. The insert module consists of two back-to-back 1 mm thick silicon sensors, each segmented into 1040 1 mm 2 pads arranged in a 40 by 26 array. A set of 16 VATAGP7.1 ASICs and a custom assembled data acquisition board were used to read out the signal from the insert module.Data were acquired in slice (2D) geometry with a Jaszczak phantom (rod diameters of 1.2-4.8 mm) filled with 18 F-FDG and the images were reconstructed with ML-EM method. Both data with full and limited angular coverage from the insert module were considered and three types of coincidence events were combined.The ratio of high-resolution data that substantially improves quality of the reconstructed image for the region near the surface of the insert module was estimated to be about 4%. Results from our previous studies suggest that such ratio could be achieved at a moderate technological expense by using an equivalent of two insert modules (an effective sensor thickness of 4 mm).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of a high resolution silicon PET insert module

Grkovski

Brzezinski²,

Cindro

et al. 2015

Nuclear Instruments and Methods in Physics Research Section A:

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“…Moreover, intense work aiming at improving the spatial resolution of PET scanners is taking place and simulation results of new designs, as well as first experimental data, show that resolution of 0.5-0.6 mm full width at half maximum (FWHM) may be achieved (Park et al, 2007, Yang et al, 2016. With scanners of the improved spatial resolution, some investigations at the sub-regional level may become feasible, at least in rats.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Imaging neuronal pathways with 52Mn PET: Toxicity evaluation in rats

et al. 2017

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Manganese in its divalent state (Mn 2+ ) has features that make it a unique tool for tracing neuronal pathways. It is taken up and transported by neurons in an activity dependent manner and it can cross synapses. It also acts as a contrast agent for magnetic resonance imaging (MRI) enabling visualization of neuronal tracts. However, due to the limited sensitivity of MRI systems relatively high Mn 2+ doses are required. This is undesirable, especially in long-term studies, because of the known toxicity of the metal.In order to overcome this limitation, we propose 52 Mn as a positron emission tomography (PET) neuronal tract tracer. We used 52 Mn for imaging dopaminergic pathways after a unilateral injection into the ventral tegmental area (VTA), as well as the striatonigral pathway after an injection into the dorsal striatum (STR) in rats. Furthermore, we tested potentially noxious effects of the radioactivity dose with a behavioral test and histological staining. 24 h after 52 Mn administration, the neuronal tracts were clearly visible in PET images and statistical analysis confirmed the observed distribution of the tracer. We noticed a behavioral impairment in some animals treated with 170 kBq of 52 Mn, most likely caused by dysfunction of dopaminergic cells. Moreover, there was a substantial DNA damage in the brain tissue after applying 150 kBq of the tracer. However, all those effects were completely eliminated by reducing the 52 Mn dose to 20-30 kBq. Crucially, the reduced dose was still sufficient for PET imaging.

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“…We have shown an improvement in image resolution from 1.7 mm FWHM without insert to 1.0 mm FWHM with the insert. Other groups have explored technologies that employ similar magnifying geometry such as Si-Si ring inside a BGO-BGO ring [17, 18], the Zoom-In system [19, 20], surgical PET imaging probe [21], time-of-flight PET imaging probe [22] and a prostate imaging probe [23]. …”

Section: Introductionmentioning

confidence: 99%

Improving PET imaging for breast cancer using virtual pinhole PET half-ring insert

Mathews

Komarov

Wu³

et al. 2013

Phys. Med. Biol.

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A PET insert with detector having smaller crystals and placed near a region of interest in a conventional PET scanner can improve image resolution locally due to the Virtual-Pinhole PET (VP-PET) effect. This improvement is from the higher spatial sampling of the imaging area near the detector. We have built a prototype half-ring PET insert for head-and-neck cancer imaging applications. In this paper, we extend the use of the insert to breast imaging and show that such a system provides high resolution images of breast and axillary lymph nodes while maintaining the full imaging field of view capability of a clinical PET scanner. We characterize the resolution and contrast recovery for tumors across the imaging field of view. First, we model the system using Monte Carlo methods to determine its theoretical limit of improvement. Simulations were conducted with hot spherical tumors embedded in background activity at tumor-to-background contrast ranging from 3:1 to 12:1. Tumors are arranged in a Derenzo-like pattern with their diameters ranging from 2 to 12 mm. Experimental studies were performed using a chest phantom with cylindrical breast attachment. Tumors of different sizes arranged in a Derenzo-like pattern with tumor-to- background ratio of 6:1 are inserted into the breast phantom. Imaging capability of mediastinum and axillary lymph nodes is explored. Both Monte Carlo simulations and experiment show clear improvement in image resolution and contrast recovery with VP-PET half ring insert. The degree of improvement in resolution and contrast recovery depends on location of the tumor. The full field of view imaging capability is shown to be maintained. Minor artifacts are introduced in certain regions.

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Design of a very high-resolution small animal PET scanner using a silicon scatter detector insert

Cited by 35 publications

References 34 publications

Evaluation of a high resolution silicon PET insert module

Evaluation of a high resolution silicon PET insert module

Imaging neuronal pathways with 52Mn PET: Toxicity evaluation in rats

Improving PET imaging for breast cancer using virtual pinhole PET half-ring insert

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