Design of a Topas-based ultrahigh-sensitive PCF biosensor for blood component detection

Islam, Mohammad Rakibul; Iftekher, A. N. M.; Mou, Farhana Akter; Rahman, Md. Moshiur; Bhuiyan, Mohammed Imamul Hassan

doi:10.1007/s00339-020-04261-3

Cited by 41 publications

(12 citation statements)

References 55 publications

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“…Boundary conditions are introduced to numerically solve the problem, and then the field function and the required performance parameters are obtained for the whole simulated domain. To simulate the realistic case and achieve convergence, a special dielectric layer with a thickness of 10% of the fiber radius is set at the fiber periphery, so that THz waves leaking into the cladding can pass through the interface and enter a perfect matched layer (PML) without reflection [ 14 , 31 ]. Here, the radius of the fiber is 1400 μm and the PML is 140 μm in thickness.…”

Section: Design Approach and Theoretical Derivationsmentioning

confidence: 99%

Ultra-High Sensitivity Terahertz Microstructured Fiber Biosensor for Diabetes Mellitus and Coronary Heart Disease Marker Detection

Xue

Zhang

Guang

et al. 2023

Sensors

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Diabetes Mellitus (DM) and Coronary Heart Disease (CHD) are among top causes of patient health issues and fatalities in many countries. At present, terahertz biosensors have been widely used to detect chronic diseases because of their accurate detection, fast operation, flexible design and easy fabrication. In this paper, a Zeonex-based microstructured fiber (MSF) biosensor is proposed for detecting DM and CHD markers by adopting a terahertz time-domain spectroscopy system. A suspended hollow-core structure with a square core and a hexagonal cladding is used, which enhances the interaction of terahertz waves with targeted markers and reduces the loss. This work focuses on simulating the transmission performance of the proposed MSF sensor by using a finite element method and incorporating a perfectly matched layer as the absorption boundary. The simulation results show that this MSF biosensor exhibits an ultra-high relative sensitivity, especially up to 100.35% at 2.2THz, when detecting DM and CHD markers. Furthermore, for different concentrations of disease markers, the MSF exhibits significant differences in effective material loss, which can effectively improve clinical diagnostic accuracy and clearly distinguish the extent of the disease. This MSF biosensor is simple to fabricate by 3D printing and extrusion technologies, and is expected to provide a convenient and capable tool for rapid biomedical diagnosis.

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Section: Design Approach and Theoretical Derivationsmentioning

confidence: 99%

Ultra-High Sensitivity Terahertz Microstructured Fiber Biosensor for Diabetes Mellitus and Coronary Heart Disease Marker Detection

Xue

Zhang

Guang

et al. 2023

Sensors

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“…The relative sensitivity coefficient is used to determine how much the evanescent field interacts with the analyte present in the core. Beer Lambert's law relates the quantity of light that is absorbed by the analyte present in the core, and it is given by [56]:

I(f)={I}_{0}(f){e}^{-r{a}_{m}{l}_{c}}

…”

Section: Performance Analysismentioning

confidence: 99%

Design of a hexagonal outlined porous cladding with vacant core photonic crystal fibre biosensor for cyanide detection at THz regime

Islam

Naser

Jaba

et al. 2022

IET Optoelectronics

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A hexagonal outlined porous cladding with vacant core photonic crystal fibre (HOPC‐VC‐PCF) sensor using Zeonex has been presented, which can detect cyanides at the THz regime. Cyanides are incredibly lethal chemicals to humans as they can rapidly cause impairment or even death; such harmful substances must be identified precisely. The proposed model has been analysed at a broad spectrum of THz regimes for three different analytes, and the numerical investigation is performed using the Finite element method (FEM). Simulation results exhibit that at optimum design parameters, extremely high sensitivity of 99.75%, negligible confinement loss of 0.5 × 10−13 cm−1, extremely low and flat dispersion of 0.12 ps THz/cm, and other excellent features were obtained. The performance analysis and the design methodology have been depicted in detail. Due to the simplistic design, fabrication of the model is easily achievable by current technology. The remarkable sensing capabilities will not only make it suited in chemicals analysis but also will play vital roles in other applications as well.

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“…When the incident light wavelength overlap with the HC-MOF bandgaps, the light will be reflected by the cladding and guided in the fiber core (Russell 2003 ; Rahaman et al 2022 ). HC-MOFs have been used extensively in various applications including nonlinear optics (Azhar et al 2013 ), imaging and spectroscopy (Stawska and Izabela 2018 ; Andreana et al 2019 ), high-intensity laser transmission (Couny et al 2007 ), and biosensing (Islam et al 2021 ; Hossain et al 2020 ). In specific, HC-MOFs are used for numerous bio sensing applications such as Cancer Cell sensing (Ahmed et al 2019 ), Pregnancy sensing (Jabin et al 2019 ), hemoglobin detection (Mitu et al 2021 ) and Covid-19 detection(Patel et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Design of highly sensitive biosensors using hollow-core microstructured fibers for plasma sensing in aids with human metabolism

Alam

Vadivel²,

Natesan³

et al. 2023

Opt Quant Electron

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Detection of low index liquid analytes in real-time, in-situ, and with high accuracy is of great importance in various scientific fields, particularly in medicine and biology. Accurate detection of plasma concentration in blood samples is one of the most significant usages of biosensors in medicine. In this paper, we report a highly sensitive biosensor using hollow core microstructure optical fibers (HC-MOFs) to detect low index liquid analytes with a particular focus on detection of plasma concentration in blood samples. We demonstrate how variations in plasma concentration in blood can change transmission spectra of the HC-MOF due to the photonic bandgap mechanism. We use the finite element approach to explore how the biosensor’s performance depends on the number of capillary rings encircling the hollow core of the fibre. An average spectral and amplitude sensitivity of 8928.57 nm/RIU and 1.21 dB/RIU is reported for the optimized design of HC-MOF for five capillary rings with a refractive index detection range of 1.333 to 1.3385 for different ratios of plasma in blood serum. The proposed biosensor can have potential application in liquid analyte detection in medicine, chemistry, and biology where real-time and accurate data about liquid analytes are necessary for human metabolism.

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Design of a Topas-based ultrahigh-sensitive PCF biosensor for blood component detection

Cited by 41 publications

References 55 publications

Ultra-High Sensitivity Terahertz Microstructured Fiber Biosensor for Diabetes Mellitus and Coronary Heart Disease Marker Detection

Ultra-High Sensitivity Terahertz Microstructured Fiber Biosensor for Diabetes Mellitus and Coronary Heart Disease Marker Detection

Design of a hexagonal outlined porous cladding with vacant core photonic crystal fibre biosensor for cyanide detection at THz regime

Design of highly sensitive biosensors using hollow-core microstructured fibers for plasma sensing in aids with human metabolism

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