Design of a thermosensitive ibuprofen-loaded nanogel as smart material applied as anti-inflammatory in tooth bleaching: An in vivo study

Moura, Samara K.S.C.F.; Santos, Milena Lima Valério dos; Nascimento, Lucas A. do; Silva, Mariana F.A. da; França, Glória Maria de; Costa, Lucas Melo da; Medeiros, Aldo Cunha; Araújo-Júnior, Raimundo F. de; Araújo, Aurigena Antunes de; Oliveira, Cláudia Nunes; Dorini, André Luís; Carvalho, Rejane Andrade de; Borges, Boniek Castillo Dutra; Silva-Júnior, Arnóbio Antônio da; Galvão, Hébel Cavalcanti

doi:10.1016/j.jddst.2022.103123

Cited by 5 publications

(4 citation statements)

References 82 publications

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“…Then, 16 studies were excluded, and the reasons for their exclusion can be found in Figure 1 and Supplementary Data 1 [ 32 33 34 35 36 37 38 39 40 41 42 43 44 ]. Twenty-seven studies meeting the inclusion criteria were selected for qualitative analysis [ 1 3 6 11 12 17 23 24 25 26 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 ].…”

Section: Resultsmentioning

confidence: 99%

Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research

Batista,

dos Reis-Prado,

Chaves

et al. 2023

Restor Dent Endod

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Objectives This study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells. Materials and Methods Electronic searches were performed in July 2023. In vivo and in vitro studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed. Results Out of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%–38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or MI Paste Plus (GC America), or following KF-desensitizing or Otosporin treatment ( n = 3). However, orally administered drugs did not reduce pulp inflammation ( n = 4). Cytotoxicity ( n = 17) was primarily assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human dental pulp cells and mouse dental papilla Cell-23 cells. Certain substances, including sodium ascorbate, butein, manganese chloride, and peroxidase, were found to reduce cytotoxicity, particularly when applied prior to bleaching. The risk of bias was high in animal studies and low in laboratory studies. Conclusions Few in vivo studies have evaluated agents to reduce the damage caused by bleaching gel to pulp tissue. Within the limitations of these studies, it was found that topical agents were effective in reducing pulp inflammation in animals and cytotoxicity. Further analyses with human pulp are required to substantiate these findings. Trial Registration PROSPERO Identifier: CRD42022337192

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Section: Resultsmentioning

confidence: 99%

Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research

Batista,

dos Reis-Prado,

Chaves

et al. 2023

Restor Dent Endod

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“…However, despite the ease and availability of oral administration (McConville 2017), the same clinical studies of tooth bleaching conclude that the pain generated by the procedure cannot be fully exploited, either in the analysis of daily or global sensitivity (Fernandes et al 2017, de Oliveira et al 2018, de Araújo et al 2021. Therefore, future perspectives should point to the use of local/topical drugs on the enamel, which could reach the pulp (Moura et al 2022) and bind to the pain-activating receptors. Codeine and dexamethasone showed strong binding to TRPA1, forming up to 17 hydrophobic interaction bonds with residues of an active site of this receptor.…”

Section: Autodock Vina© Cbdock© Dockthor© Swissdock©mentioning

confidence: 99%

“…However, despite the ease and (Fernandes et al 2017, de Oliveira et al 2018, de Araújo et al 2021. Therefore, future perspectives should point to the use of local/topical drugs on the enamel, which could reach the pulp (Moura et al 2022) and bind to the pain-activating receptors. Codeine and dexamethasone showed strong binding to TRPA1, forming up to 17 hydrophobic interaction bonds with residues of an active site of this receptor.…”

Section: Autodock Vina© Cbdock© Dockthor© Swissdock©mentioning

confidence: 99%

In silico affinity between analgesic/anti-inflammatory drugs and the transient receptor potential A1 to predict potential pharmacological managing approaches for bleaching sensitivity

COSTA,

SETTE-DE-SOUZA,

BORGES

2023

An. Acad. Bras. Ciênc.

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Reducing in-office tooth bleaching sensitivity represents a challenge for professionals. Researchers have associated the block of the pain receptor TRPA1 with reducing bleaching sensitivity. However, the chemical affinity of analgesic/antiinflammatory drugs to the TRPA1 needs to be verified. To perform a virtual screening of multiple drugs (analgesic and anti-inflammatory drugs) to verify chemical affinity for the TRPA1 receptor. The crystal structure of the TRPA1 receptor proteins was retrieved from the Protein Data Bank. The SMILES codes of the ligands were extracted from PubChem.The binding energy of the complex was obtained in ∆G -kcal/mol by AutoDock Vina© and replicated in the webservers SwissDock©, Dockthor©, and CbDock©. LigPlus© confirmed the binding sites. Codeine and dexamethasone showed regularity among all servers, even showing binding energy values of -7.9 kcal/mol for codeine and -8.1 kcal/mol for dexamethasone. Codeine and dexamethasone may be potential drugs to manage tooth bleaching sensitivity if they reach the dental pulp TRPA1 receptor.

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“…Additionally, IBU has been recognized for its effectiveness in reducing the signs and severity of gingivitis [ 4 , 5 , 6 ]. Thus, the IBU compound is regarded as safe for the treatment of oral cavity inflammation [ 7 ]. Despite its apparent low aqueous solubility, IBU can be utilized as a gel-forming component in the ISG system to carry doxycycline hyclate (DH) and leverage its self-anti-inflammatory effect.…”

Section: Introductionmentioning

confidence: 99%

Computational Insight of Phase Transformation and Drug Release Behaviour of Doxycycline-Loaded Ibuprofen-Based In-Situ Forming Gel

Puyathorn,

Tamdee,

Sirirak

et al. 2023

Pharmaceutics

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This research investigates the gel formation behaviour and drug-controlling performance of doxycycline-loaded ibuprofen-based in-situ forming gels (DH-loaded IBU-based ISGs) for potential applications in periodontal treatment. The investigation begins by exploring the physical properties and gel formation behaviour of the ISGs, with a particular focus on determining their sustained release capabilities. To gain a deeper understanding of the molecular interactions and dynamics within the ISGs, molecular dynamic (MD) simulations are employed. The effects of adding IBU and DH on reducing surface tension and water tolerance properties, thus affecting molecular properties. The phase transformation phenomenon is observed around the interface, where droplets of ISGs move out to the water phase, leading to the precipitation of IBU around the interface. The optimization of drug release profiles ensures sustained local drug release over seven days, with a burst release observed on the first day. Interestingly, different organic solvents show varying abilities to control DH release, with dimethyl sulfoxide (DMSO) demonstrating superior control compared to N-Methyl-2-pyrrolidone (NMP). MD simulations using AMBER20 software provide valuable insights into the movement of individual molecules, as evidenced by root-mean-square deviation (RMSD) values. The addition of IBU to the system results in the retardation of IBU molecule movement, particularly evident in the DMSO series, with the diffusion constant value of DH reducing from 1.2452 to 0.3372 and in the NMP series from 0.3703 to 0.2245 after adding IBU. The RMSD values indicate a reduction in molecule fluctuation of DH, especially in the DMSO system, where it decreases from over 140 to 40 Å. Moreover, their radius of gyration is influenced by IBU, with the DMSO system showing lower values, suggesting an increase in molecular compactness. Notably, the DH-IBU configuration exhibits stable pairing through H-bonding, with a higher amount of H-bonding observed in the DMSO system, which is correlated with the drug retardation efficacy. These significant findings pave the way for the development of phase transformation mechanistic studies and offer new avenues for future design and optimization formulation in the ISG drug delivery systems field.

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Design of a thermosensitive ibuprofen-loaded nanogel as smart material applied as anti-inflammatory in tooth bleaching: An in vivo study

Cited by 5 publications

References 82 publications

Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research

Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research

In silico affinity between analgesic/anti-inflammatory drugs and the transient receptor potential A1 to predict potential pharmacological managing approaches for bleaching sensitivity

Computational Insight of Phase Transformation and Drug Release Behaviour of Doxycycline-Loaded Ibuprofen-Based In-Situ Forming Gel

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