Design of a Sensitive Fluorescent Zn-Based Metal–Organic Framework Sensor for Cimetidine Monitoring in Biological and Pharmaceutical Samples

Abstract

A new highly fluorescent zinc–organic framework [Zn 2 (btca)(DMSO) 2 ] n ( Zn-MOF ) was prepared via in situ ligand formation by the solvothermal reaction of Zn(NO 3 ) 2 ·6H 2 O and pyromellitic dianhydride (PMDA) in DMSO solvent. During the solvothermal reaction, PMDA was gradually hydrolyzed to a pyromellitic acid, 1,2,4,5-benzene tetracarboxylic acid (H 4 btca), to provide a tetracarboxylic acid as a linker in the reaction medium. Single-crystal X-ray diffraction analysis exhibits a 3D porous structure with open tetragonal channels running along the crystallographic c -axis. The Zn-MOF was explored as an on-mode fluorescent sensor for tracing cimetidine in biological fluids and pharmaceutical samples in the presence of interfering species. The results show a quick response in a short time range. The characteristics of this sensor were investigated by field-emission scanning electron microscopy, dynamic light scattering, energy-dispersive X-ray analysis, powder X-ray diffraction, Fourier transform infrared and UV–vis spectroscopy as well as thermogravimetric, and elemental analyses.

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

“…The medicine cimetidine is a member of the H2 receptor antagonist drug class. 103 It is typically used for disorders linked to excess secretion of stomach acids, for examples, peptic ulcers, Zollinger−Ellison syndrome, and gastroesophageal reflux disease (GERD). 102 It is frequently used to lower stomach acid production.…”

“…To get rid of these problems, Afravi et al developed the first Zn(II)−organic fluorescent framework for the selective sensing of cimetidine in different biological fluids (human urine and plasma) and pharmaceutical samples with high selectivity. 103 Together with a short response time (3 min), the sensor displayed high sensitivity for the sensing of cimetidine through a "turn-on" response. The calculated LOD and LOQ of the sensor were 0.31 and 1.05 ng/mL with RSD of 4.1% and 3.2%.…”

A label-free aptasensor based on electrodeposition of gold nanoparticles on silver-based metal–organic frameworks for measuring ochratoxin A in black and red pepper

“…20,21 Various metal ions such as Fe 2+ , Zn 2+ , Co 2+ , Cu 2+ , Ag + and Mo 6+ , can be incorporated into MOFs. 17,[22][23][24][25][26] Moreover, some of the most typical ligands are polyamines (particularly those derived from imidazole, oxalic acid, and benzene), carboxylates, pyridyl and cyano groups, crown ethers, and phosphonates. 20 The organic linker connects to the metal using labile or empty positions.…”