Design of a polyacrylamide and gelatin hydrogel as a synthetic extracellular matrix

Torres-García, Rocío; Flores-Estrada, Jaime; Cauich-Rodríguez, Juan Valerio; Flores-Reyes, Mario; Flores-Merino, Miriam V.

doi:10.1080/00914037.2020.1825082

Cited by 13 publications

(16 citation statements)

References 48 publications

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“…n e = 1.402 + 1.338(GLN%) À 4.765(GLN%) 2 + 3.932(GLN%) 3 (8) Using this polynomial, the effective crosslink density in the desired amount of GLN in a semi-IPN structure containing 98/2 mole ratio of AAm/ITA could be determined without performing its synthesis.…”

Section: Effect Of Gln Content On Semi-ipn Strength and Crosslinking ...mentioning

confidence: 99%

“…Torres-Garcı ´a observed that the amount of pores was reduced by the incorporation of gelatin in the PAAm network in semi-interpenetrated polymer network hydrogels of PAAm/gelatin with a gelatin content of up to 0.3%. 8 As special interpenetrating networks, the use of natural polymers is preferrable to obtain double network hydrogels consisting of a polyelectrolyte polymer network as the first network and a flexible neutral polymer as the second network. In these gels, the incorporation of recoverable physical bonds, such as gelatin, in the network is an effective method against the severe softening and poor fatigue resistance observed when the initial network chain breaks after being subjected to deformation.…”

Section: Introductionmentioning

confidence: 99%

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Assessing the compressive elasticity and multi-responsive property of gelatin-containing weakly anionic copolymer gelsviasemi-IPN strategy

Ciftbudak

Orakdöğen

2022

Soft Matter

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Section: Effect Of Gln Content On Semi-ipn Strength and Crosslinking ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessing the compressive elasticity and multi-responsive property of gelatin-containing weakly anionic copolymer gelsviasemi-IPN strategy

Ciftbudak

Orakdöğen

2022

Soft Matter

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“…Due to these structural properties, hydrogels can absorb large amounts of aqueous solutions. They can be utilized in several fields including drug delivery systems, enzyme systems, medical supplies [2].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, it is used as the main ingredient in hydrogels designed for drug release, due to its high biocompatibility and easy manufacturing property. It has good permeability to hydrophobic and hydrophilic substances [2], [7]. Depending on the crosslinking density, it can increase the mechanical strength of structure.…”

Section: Introductionmentioning

confidence: 99%

Jelatin/PAAm-tabanlı IPN Hidrojelleri Kullanarak Sulu Çözeltiden Krom (VI) Uzaklaştırmasının Değerlendirmesi

Akalın

2023

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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In this work, gelatin (G)-polyacrylamide (PAAm)-based interpenetrating polymer network (IPN) hydrogels involving maleic acid (MA) was prepared using by radical polymerization. Full-IPN and semi-IPN hydrogels were synthesized by using glutaraldehyde and ethylene glycol dimethacrylate (EGDMA) as a crosslinker. The water absorbency of hydrogels was investigated, and the values increased with MA and G. The chemical structures of full-IPN and semi-IPN hydrogels were tested by Fourier Transform Infrared Spectroscopy (FTIR). Morphological test was done by using Scanning Electron Microscope/ Energy Dispersive X-ray Spectroscopy (SEM/EDX). Thermal properties were examined with Differential scanning calorimeter (DSC) analyzer and Thermogravimetric analysis (TGA). The mechanical analysis was performed with Zwick Universal Testing Machine. Thermal and mechanical stabilities of full-IPN hydrogel was higher than semi-IPN. The efficiency of adsorption parameters (contact time, initial feed concentration, and pH) on Chromium (VI) ion adsorbing property of Full-IPN hydrogel was also determined. Isotherms were explained with the Langmuir or Freundlich equations. According to the results of both isotherms, it can be said that the hydrogel surface was homogeneous, and the adsorption of Chromium (VI) occurred in a monolayer.

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“…Among biopolymer-derived hydrogels, gelatin is considered one of the most promising due to its thermoreversible gelling properties, film-forming ability, and processing versatility [ 4 , 5 , 6 ]. However, it is important to tailor their mechanical strength, rheological properties, and thermal stability to meet their target functional and processing requirements [ 7 , 8 , 9 ]. These can be achieved by formulation (e.g., gelatin concentration and incorporation of surfactants, crosslinkers, nanomaterials, or polymers) and the selection of processing methods and conditions (e.g., thermally induced phase separation, foaming, 3D printing, electrospinning, and porogen leaching) which can alter the gelatin hydrogels’ molecular structure and properties [ 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Sodium Dodecyl Sulfate in Tailoring the Rheological Properties of High-Strength Gelatin Hydrogels

Torrejon

Deng

Luo

et al. 2021

Gels

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Gelatin hydrogels are widely used materials that may require surfactants to adjust their solution’s surface tension for cell attachment, surface adsorption enhancement, or foaming. However, gelatin is a highly surface-active polymer, and its concentrated solutions usually do not require surfactants to achieve low surface tension. However, anionic surfactants, such as sodium dodecyl sulfate (SDS), interact strongly with gelatin to form complexes that impact its hydrogels’ rheological properties, influencing processability and functionality. Nevertheless, there is a lack of systematic research on the impact of these complexes on high gelatin content (i.e., high strength) hydrogels’ rheological properties. In this work, the SDS/gelatin ratio-dependent viscoelastic properties (e.g., gel strength, gelation kinetics, and melting/gelling temperature) of high-strength gelatin hydrogels were investigated using rheology and correlated to surface tension, viscometry, FTIR, and UV-Vis spectrophotometry. SDS–gelatin ratio was proved to be an important factor in tailoring the rheological properties of gelatin hydrogels. The gel strength, gelation kinetics, and melting/gelling temperature of the gelatin hydrogels linearly increased with SDS incorporation up to a maximum value, from which they started to decline. The findings of this work have wide applicability in tailoring the properties of gelatin–SDS solutions and hydrogels during their processing.

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Design of a polyacrylamide and gelatin hydrogel as a synthetic extracellular matrix

Cited by 13 publications

References 48 publications

Assessing the compressive elasticity and multi-responsive property of gelatin-containing weakly anionic copolymer gelsviasemi-IPN strategy

Assessing the compressive elasticity and multi-responsive property of gelatin-containing weakly anionic copolymer gelsviasemi-IPN strategy

Jelatin/PAAm-tabanlı IPN Hidrojelleri Kullanarak Sulu Çözeltiden Krom (VI) Uzaklaştırmasının Değerlendirmesi

Role of Sodium Dodecyl Sulfate in Tailoring the Rheological Properties of High-Strength Gelatin Hydrogels

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