Design of a Novel Electrochemical Aptasensor Based on Molybdenum Disulfide Nanosheets for Lysozyme Detection

Site-Directed Electrochemical Grafting for Amplified Detection of Antibody Pharmaceuticals

“…To demonstrate the high selectivity of the glyGPC-amplified electrochemical method, the detection currents from the target antibody pharmaceutical (i.e., TraMab), two nontarget antibody pharmaceuticals (i.e., RitMab and BevMab), three other glycoproteins (i.e., AFP, CEA, and thrombin), and two nonglycosylated proteins (i.e., HSA and hemoglobin (Hb)) were collected, and the levels of the interferents were five-fold of that of TraMab. From Figure , we can observe that only TraMab can result in a high detection current, while the detection currents from the interferents were as low as that of the blank control, showing the high selectivity of the aptamer-based capture. , …”

“…From Figure 5, we can observe that only TraMab can result in a high detection current, while the detection currents from the interferents were as low as that of the blank control, showing the high selectivity of the aptamerbased capture. 47,48 Assay of TraMab Levels in Human Serum. To demonstrate the applicability of the glyGPC-amplified electrochemical method in the quantitative assay of antibody pharmaceuticals in biological samples, the recovery assay in the presence of normal human serum (10%) as the matrix was challenged.…”