Design of a novel cognitive enhancer (8S, 10aS)-8-carbamoyl-1,2,3,6,7,8,9,10a-octahydro-5H,10H-pyrrolo[1,2-a][1,4]diazocin-5,10-dione

Benzo[1,4]diazocinone/Pyrrole Ensembles via the Catalyst‐Free Insertion of Pyrrolylacetylenic Ketones into Benzimidazoles

“…[5] The merging of diazocine structures with pyrrole rings should even more increase the biological and pharmaceutical value of the resulted molecules. It was reported that, pyrrole substituted diazocines have CNS related activities, [6] are cognitive enhancer, [7] are claimed to be HIV integrase inhibitors, [8] showed antimalarial activity against P. falciparum for both the K1 and TM4 strains, good antibacterial activity against S. aureus [9] (Figure 1).…”

Synthesis and Spectral Characterization of Benzo-[6,7][1,5]diazocino[2,1-a]isoindol-12-(14H)-one Derivatives

“…In recent years the synthesis and chemistry of medium ring heterocycles has attracted considerable attention because they are often present in biologically active natural products and because of their broad pharmacological profile [1]. Nitrogen-containing eight-membered heterocycles such as azocines and diazocines are known to exhibit a number of important biological properties [2,3,4,5]. The general strategies towards the synthesis of eight-membered heterocycles remain an active area of research and the most common synthetic approach to construct diazocine rings involves the conventional condensation reaction of 2-aminobenzophenones.…”